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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of insulin receptor signaling pathway
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Accession:GO:0046628 term browser browse the term
Definition:Any process that increases the frequency, rate or extent of insulin receptor signaling.
Synonyms:exact_synonym: positive regulation of insulin receptor signalling pathway;   up regulation of insulin receptor signaling pathway;   upregulation of insulin receptor signaling pathway
 narrow_synonym: activation of insulin receptor signaling pathway;   stimulation of insulin receptor signaling pathway


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positive regulation of insulin receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 IMP RGD PMID:18394428 RGD:2317907 NCBI chr13:51,240,470...51,260,233
Ensembl chr13:51,240,911...51,260,228
JBrowse link
G Agt angiotensinogen IDA RGD PMID:24184594 RGD:11039409 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G C1qtnf12 C1q and TNF related 12 ISO
IBA
(MGI:MGI:5317500|PMID:22275362)
PMID:21873635
RGD PMID:22275362, PMID:21873635 MGI:MGI:5317500, RGD:13792537 NCBI chr 5:173,390,901...173,395,276
Ensembl chr 5:173,390,901...173,395,276
JBrowse link
G Erfe erythroferrone IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:98,505,136...98,513,005
Ensembl chr 9:98,505,259...98,511,160
JBrowse link
G Gkap1 G kinase anchoring protein 1 ISS
ISO
GO_REF:0000024
(MGI:MGI:6201784|PMID:25586176)
UniProt
RGD
PMID:25586176 GO_REF:0000024, MGI:MGI:6201784 NCBI chr17:6,785,428...6,825,145
Ensembl chr17:6,785,428...6,825,144
JBrowse link
G Gnai2 G protein subunit alpha i2 IMP RGD PMID:11500506 RGD:13508599 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Igf2 insulin-like growth factor 2 ISO
IBA
IEA
(PMID:11500939)
PMID:21873635
GO_REF:0000107
(MGI:MGI:4438697|PMID:20032056)
RGD
Ensembl
PMID:11500939, PMID:20032056, PMID:21873635 GO_REF:0000107, MGI:MGI:4438697, RGD:13792537 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Ins2 insulin 2 ISO (PMID:14615391), (PMID:15792832), (PMID:7688386)
(PMID:7513704)
RGD PMID:7513704, PMID:7688386, PMID:14615391, PMID:15792832 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irs1 insulin receptor substrate 1 IMP
ISO
IEA
PMID:18285345
(PMID:7493946)
GO_REF:0000107
RGD
Ensembl
PMID:7493946, PMID:18285345 GO_REF:0000107, RGD:8553881 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Lep leptin IDA RGD PMID:20977462 RGD:5128575 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate IMP RGD PMID:19252893 RGD:9685323 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:25034891 RGD:13204821 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 IEA
ISO
GO_REF:0000107
(MGI:MGI:3640632|PMID:16446356)
Ensembl
RGD
PMID:16446356 GO_REF:0000107, MGI:MGI:3640632 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 ISO (MGI:MGI:5576396|PMID:24931609) RGD PMID:24931609 MGI:MGI:5576396 NCBI chr13:48,679,726...48,709,663
Ensembl chr13:48,679,774...48,705,575
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IMP RGD PMID:24085037 RGD:13208948 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 ISO (MGI:MGI:5289772|PMID:21441927), (MGI:MGI:5644010|PMID:23812417) RGD PMID:21441927, PMID:23812417 MGI:MGI:5289772, MGI:MGI:5644010 NCBI chr 7:53,878,906...54,030,110
Ensembl chr 7:53,878,610...54,027,892
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IMP RGD PMID:25199455 RGD:11533947 NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
JBrowse link
G Prkcz protein kinase C, zeta IMP PMID:9374484 UniProt PMID:9374484 RGD:8553908 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO (PMID:7493946) RGD PMID:7493946 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Serpina12 serpin family A member 12 ISO
IEA
MGI:MGI:5568548 (MGI:MGI:5563627|PMID:22837305)
GO_REF:0000107
RGD
Ensembl
PMID:22837305 GO_REF:0000107, MGI:MGI:5563627 NCBI chr 6:127,696,501...127,711,238
Ensembl chr 6:127,696,252...127,711,212
JBrowse link
G Sirt1 sirtuin 1 ISO
IEA
(PMID:21241768)
GO_REF:0000107
RGD
Ensembl
PMID:21241768 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Snx5 sorting nexin 5 ISO (PMID:25825816) RGD PMID:25825816 NCBI chr 3:138,378,032...138,397,944
Ensembl chr 3:138,378,202...138,397,870
JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 ISS
ISO
GO_REF:0000024
(MGI:MGI:3690172|PMID:11001060)
UniProt
RGD
PMID:11001060 GO_REF:0000024, MGI:MGI:3690172 NCBI chr 1:259,373,921...259,502,108
Ensembl chr 1:259,376,933...259,484,569
JBrowse link
G Sorl1 sortilin related receptor 1 ISO (PMID:27322061)
(MGI:MGI:5811185|PMID:27322061)
RGD PMID:27322061 MGI:MGI:5811185 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IDA RGD PMID:14985360 RGD:1581139 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B ISO (MGI:MGI:6120228|PMID:29420538) RGD PMID:29420538 MGI:MGI:6120228 NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704
JBrowse link
insulin receptor recycling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sorl1 sortilin related receptor 1 ISO (PMID:27322061)
(MGI:MGI:5811185|PMID:27322061)
RGD PMID:27322061 MGI:MGI:5811185 NCBI chr 8:46,228,077...46,287,171 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    positive regulation of biological process 6667
      positive regulation of signaling 2030
        positive regulation of signal transduction 1682
          positive regulation of insulin receptor signaling pathway 26
            insulin receptor recycling 1
            positive regulation of insulin receptor signaling pathway by insulin receptor internalization 0
            positive regulation of insulin receptor signaling pathway involved in determination of adult lifespan 0
Path 2
Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      response to chemical 6330
        response to organic substance 3853
          response to organonitrogen compound 1453
            response to peptide 689
              response to peptide hormone 594
                response to insulin 352
                  cellular response to insulin stimulus 267
                    insulin receptor signaling pathway 134
                      regulation of insulin receptor signaling pathway 82
                        positive regulation of insulin receptor signaling pathway 26
                          insulin receptor recycling 1
                          positive regulation of insulin receptor signaling pathway by insulin receptor internalization 0
                          positive regulation of insulin receptor signaling pathway involved in determination of adult lifespan 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.