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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrahydrofolate metabolic process
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Accession:GO:0046653 term browser browse the term
Definition:The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
Synonyms:exact_synonym: tetrahydrofolate metabolism


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tetrahydrofolate metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase ISS
ISO
GO_REF:0000024
(PMID:12096917), (PMID:21876184)
UniProt
RGD
PMID:12096917, PMID:21876184 GO_REF:0000024 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 TAS RGD PMID:2186031 RGD:1299513 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO (PMID:8218174) RGD PMID:8218174 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
JBrowse link
G Mthfr methylenetetrahydrofolate reductase IDA RGD PMID:11730351 RGD:1601423 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mthfs methenyltetrahydrofolate synthetase ISO (PMID:19738041), (PMID:7766710) RGD PMID:7766710, PMID:19738041 NCBI chr 8:96,564,877...96,614,386
Ensembl chr 8:96,564,877...96,614,348
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA
IMP
RGD PMID:11730351, PMID:21121936 RGD:1601423, RGD:7207080 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Pipox pipecolic acid and sarcosine oxidase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:64,951,986...64,964,865
Ensembl chr10:64,952,119...64,964,862
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO
IBA
(PMID:24698160)
PMID:21873635
RGD PMID:24698160, PMID:21873635 RGD:13792537 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 ISO
IBA
(PMID:24075985), (PMID:25619277)
PMID:21873635
RGD PMID:24075985, PMID:25619277, PMID:21873635 RGD:13792537 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
G Tyms thymidylate synthetase IEP 5-formyltetrahydrofolate RGD PMID:7503782 RGD:5133451 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO (MGI:MGI:5503248|PMID:23704330)
(PMID:1881876)
RGD PMID:1881876, PMID:23704330 MGI:MGI:5503248 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like ISO (PMID:12937168) RGD PMID:12937168 NCBI chr 1:40,529,092...40,719,232
Ensembl chr 1:40,529,045...40,719,391
JBrowse link
10-formyltetrahydrofolate catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 IEA GO_REF:0000002
GO_REF:0000104
InterPro
UniProt
GO_REF:0000002, GO_REF:0000104 NCBI chr 4:123,516,553...123,564,067
Ensembl chr 4:123,516,788...123,557,501
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
JBrowse link
10-formyltetrahydrofolate metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IDA RGD PMID:21163947 RGD:7244288 NCBI chr14:18,640,274...18,721,298
Ensembl chr14:18,640,277...18,720,357
JBrowse link
tetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 TAS RGD PMID:14729668 RGD:1547843 NCBI chr 4:123,516,553...123,564,067
Ensembl chr 4:123,516,788...123,557,501
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IDA RGD PMID:7057182 RGD:2301991 NCBI chr 9:78,862,013...78,882,061
Ensembl chr 9:78,862,013...78,882,060
JBrowse link
G Dhfr dihydrofolate reductase IDA
IBA
ISO
IEA
PMID:21873635
(PMID:2303423)
GO_REF:0000041
RGD
UniProt
PMID:2303423, PMID:11502523, PMID:21873635 GO_REF:0000041, RGD:1298877, RGD:13792537 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase IDA RGD PMID:4078017 RGD:2301990 NCBI chr11:31,780,477...31,805,728
Ensembl chr11:31,780,487...31,805,728
JBrowse link
G Gch1 GTP cyclohydrolase 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
tetrahydrofolate interconversion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmgdh dimethylglycine dehydrogenase IDA RGD PMID:6163778 RGD:7245485 NCBI chr 2:23,289,376...23,370,360
Ensembl chr 2:23,289,374...23,370,477
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr20:12,806,957...12,820,466
Ensembl chr20:12,806,957...12,820,466
JBrowse link
G LOC680432 similar to methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 3:121,490,787...121,493,932
Ensembl chr 3:121,490,812...121,493,714
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
(PMID:1881876)
(MGI:MGI:5503248|PMID:23704330)
UniProt
RGD
PMID:1881876, PMID:23704330, PMID:21873635 GO_REF:0000041, MGI:MGI:5503248, RGD:13792537 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 1:40,529,092...40,719,232
Ensembl chr 1:40,529,045...40,719,391
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21163947, PMID:21873635 GO_REF:0000041, RGD:7244288, RGD:13792537 NCBI chr14:18,640,274...18,721,298
Ensembl chr14:18,640,277...18,720,357
JBrowse link
G Mthfr methylenetetrahydrofolate reductase IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
UniProtKB:P53128 (PMID:10551815), (PMID:12673793), (PMID:25736335)
UniProt
RGD
PMID:10551815, PMID:12673793, PMID:25736335, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mthfs methenyltetrahydrofolate synthetase ISO
IBA
(PMID:12764149)
PMID:21873635
RGD PMID:12764149, PMID:21873635 RGD:13792537 NCBI chr 8:96,564,877...96,614,386
Ensembl chr 8:96,564,877...96,614,348
JBrowse link
G Sardh sarcosine dehydrogenase IDA RGD PMID:6163778 RGD:7245485 NCBI chr 3:5,737,203...5,802,153
Ensembl chr 3:5,737,200...5,802,129
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO
IBA
IEA
(PMID:24698160)
PMID:21873635
GO_REF:0000041
RGD
UniProt
PMID:24698160, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
G Tyms thymidylate synthetase ISO (PMID:15093541) RGD PMID:15093541 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    cellular process 18791
      cellular metabolic process 11064
        cellular modified amino acid metabolic process 187
          folic acid-containing compound metabolic process 28
            tetrahydrofolate metabolic process 21
              10-formyltetrahydrofolate metabolic process + 5
              tetrahydrofolate biosynthetic process + 7
              tetrahydrofolate interconversion 13
Path 2
Term Annotations click to browse term
  biological_process 20017
    cellular process 18791
      cellular metabolic process 11064
        organic acid metabolic process 1089
          oxoacid metabolic process 1060
            carboxylic acid metabolic process 1004
              folic acid-containing compound metabolic process 28
                tetrahydrofolate metabolic process 21
                  10-formyltetrahydrofolate metabolic process + 5
                  tetrahydrofolate biosynthetic process + 7
                  tetrahydrofolate interconversion 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.