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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrahydrofolate biosynthetic process
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Accession:GO:0046654 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
Synonyms:exact_synonym: tetrahydrofolate anabolism;   tetrahydrofolate biosynthesis;   tetrahydrofolate formation;   tetrahydrofolate synthesis
 xref: MetaCyc:FOLSYN-PWY


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tetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO RGD PMID:7057182 RGD:2301991 NCBI chr37:22,420,645...22,446,769
Ensembl chr37:22,420,603...22,446,697
JBrowse link
G DHFR dihydrofolate reductase IEA InterPro GO_REF:0000002 NCBI chr 3:26,521,214...26,556,065 JBrowse link
G GCH1 GTP cyclohydrolase 1 IEA InterPro GO_REF:0000002 NCBI chr 8:30,733,422...30,784,067
Ensembl chr 8:30,732,608...30,784,156
JBrowse link
G LOC487740 trifunctional purine biosynthetic protein adenosine-3 ISO RGD PMID:4078017 RGD:2301990 NCBI chr31:29,032,399...29,063,706 JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO (PMID:1881876)
(MGI:MGI:5503248|PMID:23704330)
BHF-UCL PMID:1881876, PMID:23704330 MGI:MGI:5503248 NCBI chr 8:38,831,672...38,889,607
Ensembl chr 8:38,831,860...38,889,453
JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO (PMID:12937168) BHF-UCL PMID:12937168 NCBI chr 1:41,316,247...41,495,226
Ensembl chr 1:41,309,419...41,495,216
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16162
    metabolic process 10637
      cellular metabolic process 9630
        cellular modified amino acid metabolic process 161
          folic acid-containing compound metabolic process 26
            folic acid-containing compound biosynthetic process 8
              tetrahydrofolate biosynthetic process 6
                10-formyltetrahydrofolate biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 16162
    metabolic process 10637
      cellular metabolic process 9630
        organic acid metabolic process 943
          oxoacid metabolic process 920
            carboxylic acid metabolic process 871
              folic acid-containing compound metabolic process 26
                folic acid-containing compound biosynthetic process 8
                  tetrahydrofolate biosynthetic process 6
                    10-formyltetrahydrofolate biosynthetic process 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.