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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrahydrofolate biosynthetic process
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Accession:GO:0046654 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
Synonyms:exact_synonym: tetrahydrofolate anabolism;   tetrahydrofolate biosynthesis;   tetrahydrofolate formation;   tetrahydrofolate synthesis
 xref: MetaCyc:FOLSYN-PWY


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tetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IEA Ensembl GO_REF:0000107 NCBI chr 2:215,311,974...215,359,745
Ensembl chr 2:215,311,956...215,349,773
JBrowse link
G DHFR dihydrofolate reductase IDA
IBA
IEA
(PMID:2303423)
(PMID:21873635)
BHF-UCL
GO_Central
UniProtKB
InterPro
PMID:2303423, PMID:21873635 GO_REF:0000002, GO_REF:0000041 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983
JBrowse link
G DHFR2 dihydrofolate reductase 2 IEA
IBA
(PMID:21873635) InterPro
UniProtKB
GO_Central
PMID:21873635 GO_REF:0000002, GO_REF:0000041 NCBI chr 3:94,057,922...94,063,389
Ensembl chr 3:94,047,836...94,063,389
JBrowse link
G DHFRP1 dihydrofolate reductase pseudogene 1 IDA
IBA
IEA
(PMID:2303423)
(PMID:21873635)
BHF-UCL
GO_Central
UniProtKB
PMID:2303423, PMID:21873635 GO_REF:0000041 NCBI chr18:26,167,862...26,171,357
Ensembl chr18:26,170,726...26,171,284
JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase IEA Ensembl GO_REF:0000107 NCBI chr21:33,503,931...33,542,892
Ensembl chr21:33,503,931...33,543,491
JBrowse link
G GCH1 GTP cyclohydrolase 1 IEA InterPro GO_REF:0000002 NCBI chr14:54,842,016...54,902,826
Ensembl chr14:54,842,008...54,902,826
JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISS
IEA
IDA
(PMID:1881876) BHF-UCL
Ensembl
PMID:1881876 GO_REF:0000024, GO_REF:0000107 NCBI chr14:64,388,353...64,460,025
Ensembl chr14:64,388,031...64,463,457
JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like IDA (PMID:12937168) BHF-UCL PMID:12937168 NCBI chr 6:150,865,684...151,101,887
Ensembl chr 6:150,865,549...151,101,887
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18626
    metabolic process 12276
      cellular metabolic process 11259
        cellular modified amino acid metabolic process 212
          folic acid-containing compound metabolic process 32
            folic acid-containing compound biosynthetic process 10
              tetrahydrofolate biosynthetic process 8
                10-formyltetrahydrofolate biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 18626
    metabolic process 12276
      cellular metabolic process 11259
        organic acid metabolic process 1264
          oxoacid metabolic process 1242
            carboxylic acid metabolic process 1149
              folic acid-containing compound metabolic process 32
                folic acid-containing compound biosynthetic process 10
                  tetrahydrofolate biosynthetic process 8
                    10-formyltetrahydrofolate biosynthetic process 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.