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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrahydrofolate biosynthetic process
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Accession:GO:0046654 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
Synonyms:exact_synonym: tetrahydrofolate anabolism;   tetrahydrofolate biosynthesis;   tetrahydrofolate formation;   tetrahydrofolate synthesis
 xref: MetaCyc:FOLSYN-PWY


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tetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 1:71,557,156...71,579,403
Ensembl chr 1:71,557,150...71,579,631
JBrowse link
G Dhfr dihydrofolate reductase ISO
IBA
(MGI:MGI:6201960|PMID:21873635) RGD
GO_Central
MGI
PMID:21873635 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr13:92,354,783...92,389,053
Ensembl chr13:92,354,726...92,389,053
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr16:91,621,395...91,646,972
Ensembl chr16:91,621,186...91,646,952
JBrowse link
G Gch1 GTP cyclohydrolase 1 IEA UniProtKB GO_REF:0000002, MGI:MGI:2152098 NCBI chr14:47,153,895...47,189,413
Ensembl chr14:47,153,895...47,189,413
JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase IMP
ISO
(MGI:MGI:5503248|PMID:23704330) BHF-UCL
MGI
PMID:23704330 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5503248 NCBI chr12:76,254,406...76,319,820
Ensembl chr12:76,255,298...76,319,803
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like ISO (MGI:MGI:2679797|PMID:12937168) MGI PMID:12937168 GO_REF:0000096, MGI:MGI:2679797, MGI:MGI:4834177 NCBI chr10:3,972,892...4,167,081
Ensembl chr10:3,973,118...4,167,081
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23360
    metabolic process 11269
      cellular metabolic process 10049
        cellular modified amino acid metabolic process 171
          folic acid-containing compound metabolic process 26
            folic acid-containing compound biosynthetic process 9
              tetrahydrofolate biosynthetic process 6
                10-formyltetrahydrofolate biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 23360
    metabolic process 11269
      cellular metabolic process 10049
        organic acid metabolic process 1030
          oxoacid metabolic process 1001
            carboxylic acid metabolic process 953
              folic acid-containing compound metabolic process 26
                folic acid-containing compound biosynthetic process 9
                  tetrahydrofolate biosynthetic process 6
                    10-formyltetrahydrofolate biosynthetic process 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.