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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrahydrofolate biosynthetic process
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Accession:GO:0046654 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
Synonyms:exact_synonym: tetrahydrofolate anabolism;   tetrahydrofolate biosynthesis;   tetrahydrofolate formation;   tetrahydrofolate synthesis
 xref: MetaCyc:FOLSYN-PWY


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tetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO RGD PMID:7057182 RGD:2301991 NCBI chrNW_004936586:1,782,581...1,809,458 JBrowse link
G Dhfr dihydrofolate reductase ISO (PMID:2303423) RGD
BHF-UCL
PMID:2303423, PMID:11502523 RGD:1298877 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:4078017 RGD:2301990 NCBI chrNW_004936500:8,750,928...8,782,303 JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO (MGI:MGI:5503248|PMID:23704330)
(PMID:1881876)
BHF-UCL PMID:1881876, PMID:23704330 MGI:MGI:5503248 NCBI chrNW_004936495:8,100,977...8,170,244 JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO (PMID:12937168) BHF-UCL PMID:12937168 NCBI chrNW_004936489:3,877,423...4,060,129 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11962
    metabolic process 7653
      cellular metabolic process 7051
        cellular modified amino acid metabolic process 127
          folic acid-containing compound metabolic process 18
            folic acid-containing compound biosynthetic process 6
              tetrahydrofolate biosynthetic process 5
                10-formyltetrahydrofolate biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 11962
    metabolic process 7653
      cellular metabolic process 7051
        organic acid metabolic process 697
          oxoacid metabolic process 682
            carboxylic acid metabolic process 651
              folic acid-containing compound metabolic process 18
                folic acid-containing compound biosynthetic process 6
                  tetrahydrofolate biosynthetic process 5
                    10-formyltetrahydrofolate biosynthetic process 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.