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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of insulin secretion
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Accession:GO:0046676 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
Synonyms:exact_synonym: down regulation of insulin secretion;   downregulation of insulin secretion
 narrow_synonym: inhibition of insulin secretion


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negative regulation of insulin secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:1598646
G Acvr1c activin A receptor type 1C JBrowse link 3 44,272,859 44,342,501 RGD:1624291
RGD:1600115
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:1624291
G Bmp8a bone morphogenetic protein 8a JBrowse link 5 141,007,462 141,033,511 RGD:1624291
G Ccn3 cellular communication network factor 3 JBrowse link 7 94,375,134 94,382,154 RGD:1624291
RGD:1600115
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:2311570
G Enho energy homeostasis associated JBrowse link 5 58,018,039 58,019,836 RGD:1624291
RGD:1600115
G Fam3d FAM3 metabolism regulating signaling molecule D JBrowse link 15 18,321,757 18,357,252 RGD:1624291
RGD:1600115
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:1624291
RGD:8553721
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:8553721
G Hadh hydroxyacyl-CoA dehydrogenase JBrowse link 2 236,353,445 236,395,067 RGD:2302227
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:9590127
G Inhbb inhibin subunit beta B JBrowse link 13 35,436,532 35,442,222 RGD:1624291
RGD:1600115
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:1624291
RGD:1600115
RGD:729325
G Kcnb1 potassium voltage-gated channel subfamily B member 1 JBrowse link 3 163,850,785 163,935,610 RGD:1600115
RGD:1624291
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 JBrowse link 1 102,103,093 102,107,134 RGD:1624291
RGD:1600115
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 JBrowse link 1 216,293,087 216,630,339 RGD:1581603
G Midn midnolin JBrowse link 7 12,414,303 12,426,712 RGD:8655525
G Mtnr1a melatonin receptor 1A JBrowse link 16 50,339,358 50,358,809 RGD:9686057
G Mtnr1b melatonin receptor 1B JBrowse link 8 14,359,270 14,373,894 RGD:9588673
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:1642149
G Npff neuropeptide FF-amide peptide precursor JBrowse link 7 144,127,084 144,127,873 RGD:2316580
G Pde8b phosphodiesterase 8B JBrowse link 2 24,718,548 24,955,533 RGD:2312519
G Pfkl phosphofructokinase, liver type JBrowse link 20 11,393,860 11,415,889 RGD:1624291
RGD:1600115
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:2316628
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
RGD:1600115
G Psmd9 proteasome 26S subunit, non-ATPase 9 JBrowse link 12 38,786,539 38,805,121 RGD:8554418
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:10043332
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:1624291
RGD:1600115
G Rest RE1-silencing transcription factor JBrowse link 14 33,131,985 33,152,019 RGD:1600115
RGD:1624291
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1600115
RGD:1624291
G Sirt4 sirtuin 4 JBrowse link 12 46,862,358 46,876,593 RGD:1624291
RGD:1600115
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:1624291
RGD:1600115
G Stxbp5l syntaxin binding protein 5-like JBrowse link 11 66,246,624 66,566,331 RGD:1624291
RGD:1600115
G Sytl4 synaptotagmin-like 4 JBrowse link X 104,763,961 104,814,152 RGD:1624291
RGD:1600115
G Uts2 urotensin 2 JBrowse link 5 168,078,748 168,084,133 RGD:2306798
G Vsnl1 visinin-like 1 JBrowse link 6 37,001,360 37,121,969 RGD:1624291
RGD:1600115
negative regulation of insulin secretion involved in cellular response to glucose stimulus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:1624291
RGD:1600115
RGD:2316628
G Crhr2 corticotropin releasing hormone receptor 2 JBrowse link 4 85,286,371 85,329,374 RGD:2306172
G Eny2 ENY2, transcription and export complex 2 subunit JBrowse link 7 83,348,656 83,358,430 RGD:9590329
G Fkbp1b FKBP prolyl isomerase 1B JBrowse link 6 29,975,863 29,987,252 RGD:1624291
RGD:1600115
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:5508687
G Jagn1 jagunal homolog 1 JBrowse link 4 145,399,885 145,404,605 RGD:11520872
G Klf7 Kruppel like factor 7 JBrowse link 9 70,740,480 70,787,913 RGD:1624291
G LOC259246 alpha-2u globulin PGCL1 RGD:1600115
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 JBrowse link 9 46,657,444 46,782,545 RGD:7495848
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 JBrowse link 2 39,322,145 39,434,535 RGD:1624291
RGD:1600115
G Pde1c phosphodiesterase 1C JBrowse link 4 86,359,762 86,925,044 RGD:2302857
G Pde3b phosphodiesterase 3B JBrowse link 1 183,892,841 184,078,071 RGD:2302857
G Pde4c phosphodiesterase 4C JBrowse link 16 20,442,305 20,466,386 RGD:2302857
G Pde8b phosphodiesterase 8B JBrowse link 2 24,718,548 24,955,533 RGD:2302857
G Pim3 Pim-3 proto-oncogene, serine/threonine kinase JBrowse link 7 129,856,467 129,863,441 RGD:1624291
RGD:1600115
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 JBrowse link 3 79,734,961 79,743,737 RGD:12904047
G Ucp2 uncoupling protein 2 JBrowse link 1 165,506,375 165,512,744 RGD:7204422

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    negative regulation of biological process 5443
      negative regulation of transport 579
        negative regulation of protein transport 206
          negative regulation of protein secretion 150
            negative regulation of insulin secretion 53
              negative regulation of insulin secretion involved in cellular response to glucose stimulus 17
Path 2
Term Annotations click to browse term
  biological_process 18166
    localization 6061
      establishment of localization 4655
        transport 4517
          nitrogen compound transport 2185
            amide transport 1867
              peptide transport 1834
                peptide secretion 687
                  regulation of peptide secretion 563
                    negative regulation of peptide secretion 163
                      negative regulation of protein secretion 150
                        negative regulation of insulin secretion 53
                          negative regulation of insulin secretion involved in cellular response to glucose stimulus 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.