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ONTOLOGY REPORT - ANNOTATIONS


Term:response to copper ion
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Accession:GO:0046688 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
Synonyms:exact_synonym: response to copper
 related_synonym: copper sensitivity/resistance


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response to copper ion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aanat aralkylamine N-acetyltransferase IDA RGD PMID:10451024 RGD:2301041 NCBI chr10:105,568,091...105,572,407
Ensembl chr10:105,568,091...105,572,403
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain IEP RGD PMID:10958805 RGD:1598689 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Aldob aldolase, fructose-bisphosphate B IEP RGD PMID:11044632 RGD:1599065 NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824
JBrowse link
G Atp7a ATPase copper transporting alpha IDA
IEP
RGD PMID:17158254, PMID:15591161 RGD:1599385, RGD:1599393 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta IEP
ISO
IEA
(PMID:15269005), (PMID:16472602), (PMID:16939419)
GO_REF:0000107
RGD
Ensembl
PMID:15269005, PMID:16472602, PMID:16939419, PMID:15591161 GO_REF:0000107, RGD:1599393 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEP RGD PMID:18289470 RGD:2293024 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP RGD PMID:18289470 RGD:2293024 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cdk1 cyclin-dependent kinase 1 IEP RGD PMID:19497425 RGD:2316369 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cp ceruloplasmin IDA RGD PMID:19700037 RGD:2314683 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cycs cytochrome c, somatic IEP RGD PMID:14608045 RGD:11352711 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 IDA RGD PMID:3348368 RGD:2307322 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Dbh dopamine beta-hydroxylase IEP RGD PMID:19079842 RGD:5129530 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP RGD PMID:20544302 RGD:4145394 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1a interleukin 1 alpha IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:12746488)
Ensembl
UniProt
RGD
PMID:12746488 GO_REF:0000024, GO_REF:0000107 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Ireb2 iron responsive element binding protein 2 IEP RGD PMID:24024382 RGD:12904019 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Lcat lecithin cholesterol acyltransferase IDA RGD PMID:7288494 RGD:1581777 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Lipc lipase C, hepatic type IEP RGD PMID:3420106 RGD:2308778 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Loxl2 lysyl oxidase-like 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:23319596)
Ensembl
UniProt
RGD
PMID:23319596 GO_REF:0000024, GO_REF:0000107 NCBI chr15:51,276,022...51,365,238
Ensembl chr15:51,303,909...51,365,234
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I IEP RGD PMID:18567746 RGD:2302302 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b IEP RGD PMID:10535524 RGD:2298958 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IEP RGD PMID:17418555 RGD:1642079 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase IEP RGD PMID:15629125 RGD:2302420 NCBI chr 9:111,028,543...111,177,588
Ensembl chr 9:111,028,575...111,177,602
JBrowse link
G Prnp prion protein IDA RGD PMID:16148034 RGD:1599958 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G S100a13 S100 calcium binding protein A13 IEP RGD PMID:12754378 RGD:2316108 NCBI chr 2:189,906,022...189,912,516
Ensembl chr 2:189,906,022...189,912,516
JBrowse link
G Sod1 superoxide dismutase 1 IMP
IEP
RGD PMID:14747682, PMID:12514262 RGD:1581098, RGD:634854 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod3 superoxide dismutase 3 IMP RGD PMID:16081273 RGD:1581097 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Sord sorbitol dehydrogenase IDA RGD PMID:11044632 RGD:1599065 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Tfrc transferrin receptor IEP RGD PMID:17298691 RGD:2292032 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tk1 thymidine kinase 1 IEP RGD PMID:6642140 RGD:2317232 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
cellular response to copper ion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC128848.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr19:11,302,125...11,302,938 JBrowse link
G Aoc1 amine oxidase, copper containing 1 ISO
ISS
(PMID:9399025)
GO_REF:0000024
RGD
UniProt
PMID:9399025 GO_REF:0000024 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
JBrowse link
G App amyloid beta precursor protein IEP RGD PMID:18583042 RGD:13782134 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp1 aquaporin 1 ISS
ISO
GO_REF:0000024
(PMID:7491270), (PMID:8584435)
UniProt
RGD
PMID:7491270, PMID:8584435 GO_REF:0000024 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp2 aquaporin 2 IEA
ISO
GO_REF:0000107
(PMID:8584435)
Ensembl
RGD
PMID:8584435 GO_REF:0000107 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
JBrowse link
G Atp7a ATPase copper transporting alpha IEP
IDA
RGD PMID:23174565, PMID:20671235 RGD:11341702, RGD:11341707 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta IMP
IEP
RGD PMID:24614235, PMID:24614235 RGD:11341682, RGD:11341682 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Bace1 beta-secretase 1 IEP RGD PMID:18583042 RGD:13782134 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Becn1 beclin 1 IEP RGD PMID:22540380 RGD:11561917 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP RGD PMID:24599699 RGD:11352816 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 IEP RGD PMID:24599699 RGD:11352816 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Daxx death-domain associated protein ISO
IEA
ISS
(PMID:15016915)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15016915 GO_REF:0000024, GO_REF:0000107 NCBI chr20:5,480,103...5,485,962
Ensembl chr20:5,480,103...5,485,926
JBrowse link
G Eln elastin IEP RGD PMID:18847363 RGD:9585685 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Hsf1 heat shock transcription factor 1 ISO (PMID:15016915) RGD PMID:15016915 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP RGD PMID:22540380 RGD:11561917 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Mt1 metallothionein 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt1m metallothionein 1M IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:3,677,460...3,677,838
Ensembl chr20:3,677,474...3,677,847
JBrowse link
G Mt2A metallothionein 2A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mt3 metallothionein 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Mt4 metallothionein 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:11,339,767...11,341,863
Ensembl chr19:11,339,767...11,341,863
JBrowse link
G Nfe2l1 nuclear factor, erythroid 2-like 1 ISO MGI:MGI:2385929 (MGI:MGI:5577246|PMID:24462598) RGD PMID:24462598 MGI:MGI:5577246 NCBI chr10:84,686,762...84,699,313
Ensembl chr10:84,682,460...84,698,886
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO MGI:MGI:2385925 (MGI:MGI:5577246|PMID:24462598) RGD PMID:24462598 MGI:MGI:5577246 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Prnp prion protein ISO (PMID:16254249) RGD PMID:16254249 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Snca synuclein alpha ISO (PMID:21320589) RGD PMID:21320589 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Txnrd1 thioredoxin reductase 1 IEP RGD PMID:19781568 RGD:5130971 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
detoxification of copper ion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC128848.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr19:11,302,125...11,302,938 JBrowse link
G Atp7a ATPase copper transporting alpha ISO MGI:MGI:1856466 (MGI:MGI:65135|PMID:7509170) RGD PMID:7509170 MGI:MGI:65135 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Mt1 metallothionein 1 ISO
IBA
MGI:MGI:97172|MGI:MGI:99400 (MGI:MGI:80756|PMID:8640230)
PMID:21873635
RGD PMID:8640230, PMID:21873635 MGI:MGI:80756, RGD:13792537 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt1m metallothionein 1M IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:3,677,460...3,677,838
Ensembl chr20:3,677,474...3,677,847
JBrowse link
G Mt2A metallothionein 2A ISO
IBA
MGI:MGI:97171|MGI:MGI:99400 (MGI:MGI:80756|PMID:8640230)
PMID:21873635
RGD PMID:8640230, PMID:21873635 MGI:MGI:80756, RGD:13792537 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mt3 metallothionein 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Mt4 metallothionein 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:11,339,767...11,341,863
Ensembl chr19:11,339,767...11,341,863
JBrowse link
G Park7 Parkinsonism associated deglycase ISO
IEA
ISS
(PMID:23792957)
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5516159|PMID:23792957)
RGD
Ensembl
UniProt
PMID:23792957 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5516159 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      response to chemical 6330
        response to inorganic substance 818
          response to metal ion 514
            response to copper ion 52
              cellular response to copper ion + 25
              stress response to copper ion + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.