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ONTOLOGY REPORT - ANNOTATIONS


Term:bone remodeling
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Accession:GO:0046849 term browser browse the term
Definition:The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
Synonyms:exact_synonym: bone remodelling
 xref: Wikipedia:Bone_remodeling


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bone remodeling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07034833.1 RGD:13792537
G AABR07071701.1 RGD:13792537
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:13792728
G Efna2 ephrin A2 JBrowse link 7 12,382,636 12,393,266 RGD:1624291
RGD:13792537
G Efna4 ephrin A4 JBrowse link 2 188,655,920 188,660,179 RGD:13792537
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 1 21,748,201 21,813,205 RGD:1624291
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:1624291
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:1600115
RGD:1624291
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:13792728
G Htr1b 5-hydroxytryptamine receptor 1B JBrowse link 8 89,113,984 89,130,830 RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1601024
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 JBrowse link 3 101,051,960 101,152,119 RGD:1624291
RGD:1600115
G LOC102554748 nidogen-2-like JBrowse link 7 380,313 427,615 RGD:13792537
G LOC24906 RoBo-1 JBrowse link 10 43,871,628 43,880,549 RGD:1299027
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:13792537
RGD:1624291
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
RGD:13792537
G Ltbp3 latent transforming growth factor beta binding protein 3 JBrowse link 1 221,099,155 221,116,096 RGD:1624291
G Mitf melanocyte inducing transcription factor JBrowse link 4 130,172,484 130,425,496 RGD:1624291
G Notch2 notch receptor 2 JBrowse link 2 200,187,184 200,320,403 RGD:1600115
RGD:1624291
G P3h4 prolyl 3-hydroxylase family member 4 (non-enzymatic) JBrowse link 10 88,318,231 88,325,326 RGD:1600115
RGD:1624291
G Ptprv protein tyrosine phosphatase, receptor type, V JBrowse link 13 51,935,239 51,956,262 RGD:632779
G Rassf2 Ras association domain family member 2 JBrowse link 3 124,574,088 124,610,267 RGD:1624291
RGD:1600115
G Slc34a1 solute carrier family 34 member 1 JBrowse link 17 9,747,766 9,762,739 RGD:1624291
G Snx10 sorting nexin 10 JBrowse link 4 81,311,490 81,375,248 RGD:1624291
G Spp2 secreted phosphoprotein 2 JBrowse link 9 95,501,512 95,509,646 RGD:1600115
G Tph1 tryptophan hydroxylase 1 JBrowse link 1 102,669,868 102,699,442 RGD:1624291
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
G Wnt16 Wnt family member 16 JBrowse link 4 49,369,246 49,388,156 RGD:1624291
bone resorption term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acp5 acid phosphatase 5, tartrate resistant JBrowse link 8 23,142,733 23,149,067 RGD:1298628
RGD:13792537
RGD:1600115
RGD:1624291
RGD:2315871
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1624291
RGD:1600115
G Ccdc154 coiled-coil domain containing 154 JBrowse link 10 14,518,240 14,529,920 RGD:1624291
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Ctsk cathepsin K JBrowse link 2 196,655,469 196,666,447 RGD:1601030
RGD:1624291
G Ctss cathepsin S JBrowse link 2 197,655,780 197,679,768 RGD:5687153
G Gpr55 G protein-coupled receptor 55 JBrowse link 9 92,961,431 93,011,157 RGD:1624291
G Hnf1a HNF1 homeobox A JBrowse link 12 47,407,811 47,433,342 RGD:1624291
G Ihh Indian hedgehog signaling molecule JBrowse link 9 82,208,223 82,214,440 RGD:1624291
G Il7 interleukin 7 JBrowse link 2 96,427,884 96,474,979 RGD:1624291
RGD:1600115
G Lrrk1 leucine-rich repeat kinase 1 JBrowse link 1 127,166,866 127,301,053 RGD:1624291
G Mir34a microRNA 34a JBrowse link 5 167,092,491 167,092,592 RGD:1624291
G Ncdn neurochondrin JBrowse link 5 144,769,452 144,779,271 RGD:1624291
G Nox4 NADPH oxidase 4 JBrowse link 1 150,796,359 150,976,186 RGD:1624291
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:61525
G Pth1r parathyroid hormone 1 receptor JBrowse link 8 118,984,531 119,012,803 RGD:1624291
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1624291
RGD:1600115
G Rab3d RAB3D, member RAS oncogene family JBrowse link 8 22,920,238 22,929,368 RGD:1624291
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:729760
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1599401
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:1599401
G Snx10 sorting nexin 10 JBrowse link 4 81,311,490 81,375,248 RGD:1624291
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1600115
RGD:1624291
RGD:13792537
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 JBrowse link 1 219,126,687 219,139,466 RGD:1624291
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:1624291
G Tpp1 tripeptidyl peptidase 1 JBrowse link 1 170,588,036 170,594,159 RGD:1600115
RGD:8554137
RGD:1624291
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
negative regulation of bone remodeling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1600115
RGD:1624291
negative regulation of bone resorption term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:1624291
G Cartpt CART prepropeptide JBrowse link 2 30,125,249 30,127,408 RGD:1624291
G Cd38 CD38 molecule JBrowse link 14 71,714,768 71,754,990 RGD:2307268
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
G Cldn18 claudin 18 JBrowse link 8 107,933,725 107,960,656 RGD:1624291
G Csk C-terminal Src kinase JBrowse link 8 62,405,714 62,424,707 RGD:5134371
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:7257714
G Fshr follicle stimulating hormone receptor JBrowse link 6 12,796,383 12,997,817 RGD:1624291
G Gpr137b G protein-coupled receptor 137B JBrowse link 17 90,670,852 90,709,003 RGD:1624291
RGD:13792537
G Hamp hepcidin antimicrobial peptide JBrowse link 1 89,368,021 89,369,960 RGD:1624291
G Iapp islet amyloid polypeptide JBrowse link 4 176,509,863 176,517,903 RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link 9 94,745,220 94,850,778 RGD:1624291
RGD:1600115
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Tmem119 transmembrane protein 119 JBrowse link 12 48,598,498 48,605,704 RGD:1624291
G Tnfrsf11b TNF receptor superfamily member 11B JBrowse link 7 93,798,580 93,826,586 RGD:730196
RGD:1624170
G Ubash3b ubiquitin associated and SH3 domain containing, B JBrowse link 8 45,224,053 45,375,450 RGD:1624291
RGD:13792537
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1580559
ossification involved in bone remodeling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cthrc1 collagen triple helix repeat containing 1 JBrowse link 7 77,966,722 77,977,004 RGD:1624291
G Gdf5 growth differentiation factor 5 JBrowse link 3 151,482,672 151,487,129 RGD:2289026
G Ptn pleiotrophin JBrowse link 4 64,239,156 64,330,996 RGD:1600115
RGD:1624291
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:1624291
RGD:1600115
positive regulation of bone resorption term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam8 ADAM metallopeptidase domain 8 JBrowse link 1 212,317,510 212,332,895 RGD:1624291
G Ahsg alpha-2-HS-glycoprotein JBrowse link 11 81,711,269 81,717,594 RGD:1625797
G Atp6ap1 ATPase H+ transporting accessory protein 1 JBrowse link X 156,407,973 156,415,053 RGD:1600115
RGD:1624291
G Car2 carbonic anhydrase 2 JBrowse link 2 88,097,740 88,112,868 RGD:1600722
G Dcstamp dendrocyte expressed seven transmembrane protein JBrowse link 7 78,642,016 78,651,763 RGD:1624291
G Def8 differentially expressed in FDCP 8 homolog JBrowse link 19 56,238,353 56,259,867 RGD:1624291
RGD:1600115
G Dlk1 delta like non-canonical Notch ligand 1 JBrowse link 6 133,576,513 133,583,751 RGD:1624291
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:10395245
G Fcgr3a Fc fragment of IgG receptor IIIa JBrowse link 13 89,385,775 89,396,047 RGD:1624291
G Fshb follicle stimulating hormone subunit beta JBrowse link 3 98,088,321 98,092,131 RGD:1624291
G Idua alpha-L-iduronidase JBrowse link 14 2,041,828 2,056,762 RGD:1624291
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:5024929
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
G Ltbp3 latent transforming growth factor beta binding protein 3 JBrowse link 1 221,099,155 221,116,096 RGD:1624291
G Mc4r melanocortin 4 receptor JBrowse link 18 62,612,838 62,614,725 RGD:1624291
G Oscar osteoclast associated Ig-like receptor JBrowse link 1 64,182,174 64,188,658 RGD:1624291
G Plekhm1 pleckstrin homology and RUN domain containing M1 JBrowse link 10 91,451,890 91,500,675 RGD:1624291
RGD:1600115
G Ppargc1b PPARG coactivator 1 beta JBrowse link 18 56,626,725 56,650,524 RGD:1624291
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:1624291
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:729815
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581129
RGD:13792537
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1600115
RGD:1624291
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:1624291
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:1624291
RGD:1600115
G Tmem64 transmembrane protein 64 JBrowse link 5 28,850,864 28,898,203 RGD:1624291
G Tnfrsf11a TNF receptor superfamily member 11A JBrowse link 13 25,778,306 25,835,802 RGD:1624291
RGD:13792537
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:730134
RGD:1624291
regulation of bone remodeling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cartpt CART prepropeptide JBrowse link 2 30,125,249 30,127,408 RGD:1624291
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:1624291
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:1624291
G Inpp4b inositol polyphosphate-4-phosphatase type II B JBrowse link 19 29,592,889 30,341,528 RGD:1624291
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:1624291
RGD:1600115
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:1624291
RGD:1600115
G Mdk midkine JBrowse link 3 80,841,003 80,843,895 RGD:1600115
RGD:1624291
G Mepe matrix extracellular phosphoglycoprotein JBrowse link 14 6,782,011 6,793,561 RGD:70633
G Suco SUN domain containing ossification factor JBrowse link 13 79,736,485 79,801,133 RGD:1600115
RGD:13792537
RGD:1624291
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:1624291
RGD:1600115
regulation of bone resorption term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Calcr calcitonin receptor JBrowse link 4 28,627,439 28,702,559 RGD:1624291
G Car2 carbonic anhydrase 2 JBrowse link 2 88,097,740 88,112,868 RGD:1342423
G Csf1r colony stimulating factor 1 receptor JBrowse link 18 56,414,493 56,458,300 RGD:2293713
G Gpr137 G protein-coupled receptor 137 JBrowse link 1 222,194,266 222,197,252 RGD:13792537
G Il20ra interleukin 20 receptor subunit alpha JBrowse link 1 15,180,328 15,222,785 RGD:1624291
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:1624291
RGD:1600115
G Pdk4 pyruvate dehydrogenase kinase 4 JBrowse link 4 30,546,772 30,556,774 RGD:1600115
RGD:1624291
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:1624291
RGD:1600115
G Siglec15 sialic acid binding Ig-like lectin 15 JBrowse link 18 74,403,384 74,417,333 RGD:1624291
RGD:13792537

Term paths to the root
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Term Annotations click to browse term
  biological_process 19578
    multicellular organismal process 8913
      tissue remodeling 222
        bone remodeling 116
          bone resorption + 79
          negative regulation of bone remodeling + 20
          ossification involved in bone remodeling 5
          positive regulation of bone remodeling + 27
          regulation of bone remodeling + 64
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.