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ONTOLOGY REPORT - ANNOTATIONS


Term:peptide-O-fucosyltransferase activity
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Accession:GO:0046922 term browser browse the term
Definition:Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor.
Synonyms:related_synonym: GDP-L-fucose:polypeptide fucosyltransferase activity;   GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity;   GDP-fucose protein O-fucosyltransferase activity;   GDP-fucose:polypeptide fucosyltransferase activity
 xref: EC:2.4.1.221;   MetaCyc:2.4.1.221-RXN;   reactome:R-HSA-1912349 "Fucosylation of Pre-NOTCH by POFUT1";   reactome:R-HSA-5173192 "POFUT2 transfers fucose to TSR domain-containing proteins"


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peptide-O-fucosyltransferase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POFUT1 protein O-fucosyltransferase 1 TAS
IDA
(PMID:11698403)
(PMID:15653671)
UniProtKB PMID:11698403, PMID:15653671 NCBI chr20:32,207,880...32,238,658
Ensembl chr20:32,207,880...32,238,658
JBrowse link
G POFUT2 protein O-fucosyltransferase 2 TAS
IEA
IBA
IDA
(PMID:21873635)
(PMID:22588082)
Reactome
UniProt
GO_Central
UniProtKB
PMID:21873635, PMID:22588082 GO_REF:0000003, Reactome:R-HSA-5173192 NCBI chr21:45,263,928...45,287,914
Ensembl chr21:45,263,928...45,287,898
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18823
    catalytic activity 5961
      catalytic activity, acting on a protein 2401
        peptide-O-fucosyltransferase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 18823
    catalytic activity 5961
      transferase activity 2391
        transferase activity, transferring glycosyl groups 293
          transferase activity, transferring hexosyl groups 212
            fucosyltransferase activity 14
              peptide-O-fucosyltransferase activity 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.