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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular ketone body metabolic process
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Accession:GO:0046950 term browser browse the term
Definition:The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.
Synonyms:exact_synonym: cellular ketone body metabolism


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cellular ketone body metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oxct1 3-oxoacid CoA transferase 1 IEP
IBA
ISO
PMID:21873635
(PMID:9671268)
(MGI:MGI:2664113|PMID:12534938)
RGD PMID:9671268, PMID:12534938, PMID:3860190, PMID:21873635 MGI:MGI:2664113, RGD:2326212, RGD:13792537 NCBI chr 2:53,859,738...54,007,733
Ensembl chr 2:53,859,737...54,007,756
JBrowse link
G Oxct2a 3-oxoacid CoA transferase 2A ISO (MGI:MGI:2664113|PMID:12534938) RGD PMID:12534938 MGI:MGI:2664113 NCBI chr 5:141,016,542...141,018,832 JBrowse link
G Oxct2b 3-oxoacid CoA transferase 2B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:140,813,957...140,815,711 JBrowse link
ketone body biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase IDA
IBA
ISO
PMID:21873635
(PMID:22847177), (PMID:22865860), (PMID:9200711)
RGD PMID:9200711, PMID:22847177, PMID:22865860, PMID:2573547, PMID:21873635 RGD:1599519, RGD:13792537 NCBI chr 5:154,294,841...154,308,582
Ensembl chr 5:154,294,806...154,308,640
JBrowse link
G Hmgcll1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:22847177), (PMID:22865860)
UniProt
RGD
PMID:22847177, PMID:22865860, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:83,069,837...83,204,778
Ensembl chr 8:83,070,545...83,205,441
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 TAS
ISO
IEP
(PMID:23751782) RGD PMID:23751782, PMID:8097464, PMID:12399220 RGD:728598, RGD:2326121 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Slc27a5 solute carrier family 27 member 5 ISO
IBA
MGI:MGI:3757682 (MGI:MGI:3722951|PMID:16618416)
PMID:21873635
RGD PMID:16618416, PMID:21873635 MGI:MGI:3722951, RGD:13792537 NCBI chr 1:65,576,599...65,587,192
Ensembl chr 1:65,576,535...65,587,186
JBrowse link
ketone body catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:1979337) RGD PMID:1979337 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 IEP RGD PMID:5116556 RGD:2326095 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 ISO MGI:MGI:4364940 (MGI:MGI:4946851|PMID:21209089) RGD PMID:21209089 MGI:MGI:4946851 NCBI chr 2:53,859,738...54,007,733
Ensembl chr 2:53,859,737...54,007,756
JBrowse link
G Oxct2b 3-oxoacid CoA transferase 2B IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:140,813,957...140,815,711 JBrowse link

Term paths to the root
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  biological_process 20017
    metabolic process 12256
      cellular metabolic process 11064
        cellular ketone body metabolic process 9
          ketone body biosynthetic process + 4
          ketone body catabolic process + 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.