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Term:acylglycerol lipase activity
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Accession:GO:0047372 term browser browse the term
Definition:Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
Synonyms:exact_synonym: fatty acyl monoester lipase activity;   glycerol-ester acylhydrolase activity;   monoacylglycerol hydrolase activity;   monoacylglycerol lipase activity;   monoacylglycerolipase activity;   monoglyceridase activity;   monoglyceride hydrolase activity;   monoglyceride lipase activity;   monoglyceridyllipase activity
 xref: EC:;   MetaCyc:;   RHEA:34019;   reactome:R-HSA-1482543 "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL";   reactome:R-HSA-163595 "2-acylglycerol + H2O -> glycerol + fatty acid";   reactome:R-HSA-192422 "Digestion of triacylglycerols by extracellular PTL:colipase";   reactome:R-HSA-192425 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)";   reactome:R-HSA-192430 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)";   reactome:R-HSA-192434 "Digestion of diacylglycerols by extracellular PTL:colipase";   reactome:R-HSA-192475 "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2";   reactome:R-HSA-426032 "DAG is metabolized by DAGL to 2-AG";   reactome:R-HSA-426043 "2-AG hydrolysis to arachidonate by MAGL";   reactome:R-HSA-5694462 "ABHD6,12 hydrolyse 3AG"

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acylglycerol lipase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABHD1 abhydrolase domain containing 1 JBrowse link 3 111,996,138 112,002,127 RGD:14298760
G ABHD12 abhydrolase domain containing 12, lysophospholipase JBrowse link 17 30,997,477 31,056,307 RGD:14298760
G ABHD12B abhydrolase domain containing 12B JBrowse link 1 180,635,479 180,662,432 RGD:14298760
G ABHD15 abhydrolase domain containing 15 JBrowse link 12 45,752,848 45,761,850 RGD:14298760
G ABHD16A abhydrolase domain containing 16A, phospholipase JBrowse link 7 23,800,932 23,814,920 RGD:14298760
G ABHD16B abhydrolase domain containing 16B JBrowse link 17 62,729,995 62,732,060 RGD:14298760
G ABHD2 abhydrolase domain containing 2, acylglycerol lipase JBrowse link 7 54,655,694 54,776,140 RGD:14298760
G ABHD3 abhydrolase domain containing 3, phospholipase JBrowse link 6 106,851,625 106,917,720 RGD:14298760
G ABHD6 abhydrolase domain containing 6, acylglycerol lipase JBrowse link 13 39,982,536 40,055,467 RGD:14298760
G FAAH fatty acid amide hydrolase JBrowse link 6 165,060,279 165,079,340 RGD:14298760
G LIPC lipase C, hepatic type JBrowse link 1 113,433,684 113,604,139 RGD:9068941
G LIPE lipase E, hormone sensitive type JBrowse link 6 49,543,671 49,560,126 RGD:14298760
G MGLL monoglyceride lipase JBrowse link 13 72,480,395 72,568,964 RGD:14298760
G PNLIPRP2 pancreatic lipase related protein 2 JBrowse link 14 126,817,647 126,839,273 RGD:14298760

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  molecular_function 17331
    catalytic activity 5430
      hydrolase activity 2333
        hydrolase activity, acting on ester bonds 731
          carboxylic ester hydrolase activity 122
            acylglycerol lipase activity 14
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.