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Term:protein-glucosylgalactosylhydroxylysine glucosidase activity
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Accession:GO:0047402 term browser browse the term
Definition:Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins.
Synonyms:related_synonym: 2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity;   protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity
 xref: EC:;   MetaCyc:;   RHEA:11068

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protein-glucosylgalactosylhydroxylysine glucosidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PGGHG protein-glucosylgalactosylhydroxylysine glucosidase ISO (PMID:26682924) UniProtKB PMID:26682924 NCBI chr11:284,672...291,814
Ensembl chr11:329,289...335,856
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Term Annotations click to browse term
  molecular_function 14941
    catalytic activity 3703
      catalytic activity, acting on a protein 1538
        protein-glucosylgalactosylhydroxylysine glucosidase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 14941
    catalytic activity 3703
      hydrolase activity 1421
        hydrolase activity, acting on glycosyl bonds 89
          hydrolase activity, hydrolyzing O-glycosyl compounds 67
            glucosidase activity 7
              protein-glucosylgalactosylhydroxylysine glucosidase activity 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.