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ONTOLOGY REPORT - ANNOTATIONS


Term:ATP-dependent NAD(P)H-hydrate dehydratase activity
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Accession:GO:0047453 term browser browse the term
Definition:Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate.
Synonyms:exact_synonym: ATP-dependent H(4)NAD(P)OH dehydratase activity;   ATP-dependent H4NAD(P)OH dehydratase activity;   reduced nicotinamide adenine dinucleotide hydrate dehydratase activity
 related_synonym: (6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing);   (6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)
 xref: EC:4.2.1.93;   KEGG_REACTION:R00129;   MetaCyc:4.2.1.93-RXN;   RHEA:19017;   reactome:R-HSA-6806967 "CARKD dehydrates S-NAD(P)HX to NADPH"


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ATP-dependent NAD(P)H-hydrate dehydratase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Naxd NAD(P)HX dehydratase IDA
IEA
ISO
IBA
PMID:24611804
GO_REF:0000003
(PMID:30576410)
PMID:21873635
UniProt
RGD
PMID:30576410, PMID:24611804, PMID:21873635 GO_REF:0000003, RGD:10047272, RGD:13792537 NCBI chr16:83,326,228...83,342,711
Ensembl chr16:83,326,301...83,342,667
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  molecular_function 20457
    catalytic activity 6065
      lyase activity 212
        carbon-oxygen lyase activity 92
          hydro-lyase activity 71
            ATP-dependent NAD(P)H-hydrate dehydratase activity 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.