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ONTOLOGY REPORT - ANNOTATIONS


Term:vascular endothelial growth factor receptor signaling pathway
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Accession:GO:0048010 term browser browse the term
Definition:Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Comment:In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
Synonyms:exact_synonym: VEGF receptor signaling pathway;   VEGF receptor signalling pathway;   VEGFR signaling pathway
 never_in_taxon: NCBITaxon:2 ! Bacteria;   NCBITaxon:2157 ! Archaea;   NCBITaxon:4751 ! Fungi


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vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcar1 BCAR1 scaffold protein, Cas family member ISO
IEA
(PMID:21245381)
GO_REF:0000107
RGD
Ensembl
PMID:21245381 GO_REF:0000107 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IMP RGD PMID:14693680 RGD:1580560 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO MGI:MGI:1934260 (MGI:MGI:1277612|PMID:9689083)
(PMID:11312102), (PMID:1312256), (PMID:9299537)
RGD PMID:1312256, PMID:9299537, PMID:9689083, PMID:11312102 MGI:MGI:1277612 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 IMP
ISO
IEA
UniProtKB:P97946 (PMID:11532940), (PMID:11574540), (PMID:19779139), (PMID:9012504)
GO_REF:0000107
RGD
Ensembl
PMID:9012504, PMID:11532940, PMID:11574540, PMID:19779139, PMID:11683876 GO_REF:0000107, RGD:727326 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599
JBrowse link
G Foxc1 forkhead box C1 ISO MGI:MGI:1347481 (MGI:MGI:3701373|PMID:16678147) RGD PMID:16678147 MGI:MGI:3701373 NCBI chr17:33,947,501...33,951,484
Ensembl chr17:33,947,506...33,951,484
JBrowse link
G Foxc2 forkhead box C2 ISO MGI:MGI:1347466 (MGI:MGI:3701373|PMID:16678147) RGD PMID:16678147 MGI:MGI:3701373 NCBI chr19:53,044,379...53,047,081
Ensembl chr19:53,044,379...53,047,081
JBrowse link
G Kdr kinase insert domain receptor IMP
ISO
ISS
IEA
(PMID:10102632), (PMID:11387210), (PMID:15215251), (PMID:23529610)
GO_REF:0000024
GO_REF:0000002
(MGI:MGI:3047093|PMID:8356051)
RGD
UniProt
InterPro
PMID:8356051, PMID:10102632, PMID:11387210, PMID:15215251, PMID:23529610, PMID:9442048, PMID:18614764, PMID:18221855 GO_REF:0000002, GO_REF:0000024, MGI:MGI:3047093, RGD:729081, RGD:2301848, RGD:2292019 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO
IEA
(PMID:18440775)
GO_REF:0000107
RGD
Ensembl
PMID:18440775 GO_REF:0000107 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 ISO
IBA
(PMID:18440775)
PMID:21873635
RGD PMID:18440775, PMID:21873635 RGD:13792537 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Nrp1 neuropilin 1 ISO (PMID:21245381)
MGI:MGI:2450311|MGI:MGI:3512101 (MGI:MGI:3505728|PMID:12852851), (MGI:MGI:5490930|PMID:23639442)
RGD PMID:12852851, PMID:21245381, PMID:23639442 MGI:MGI:3505728, MGI:MGI:5490930 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Pgf placental growth factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
JBrowse link
G Prkd1 protein kinase D1 ISO (PMID:18059339) RGD PMID:18059339 NCBI chr 6:71,035,017...71,349,531
Ensembl chr 6:71,035,332...71,349,249
JBrowse link
G Prkd2 protein kinase D2 ISO (PMID:18059339) RGD PMID:18059339 NCBI chr 1:78,767,911...78,796,223
Ensembl chr 1:78,767,911...78,796,231
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO (PMID:21245381)
(MGI:MGI:3810237|PMID:17698736)
RGD PMID:17698736, PMID:21245381 MGI:MGI:3810237 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Sulf1 sulfatase 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:16778174)
Ensembl
UniProt
RGD
PMID:16778174 GO_REF:0000024, GO_REF:0000107 NCBI chr 5:5,999,520...6,186,901
Ensembl chr 5:5,999,475...6,186,329
JBrowse link
G Vegfa vascular endothelial growth factor A IMP
ISO
IBA
(PMID:1312256), (PMID:21245381), (PMID:23639442), (PMID:7929439)
PMID:21873635
(MGI:MGI:74931|PMID:1592003)
RGD PMID:1312256, PMID:1592003, PMID:7929439, PMID:21245381, PMID:23639442, PMID:18614764, PMID:21873635 MGI:MGI:74931, RGD:2301848, RGD:13792537 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfb vascular endothelial growth factor B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link
G Vegfc vascular endothelial growth factor C ISO
IBA
ISS
(PMID:23878260)
PMID:21873635
MGI:MGI:95561 (MGI:MGI:1201694|PMID:9247316), (MGI:MGI:5568630|PMID:24552833), (MGI:MGI:85073|PMID:9012504)
GO_REF:0000024
RGD
UniProt
PMID:9012504, PMID:9247316, PMID:23878260, PMID:24552833, PMID:21873635 GO_REF:0000024, MGI:MGI:1201694, MGI:MGI:5568630, MGI:MGI:85073, RGD:13792537 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Vegfd vascular endothelial growth factor D IMP
IEA
ISO
GO_REF:0000107
UniProtKB:P35916 (MGI:MGI:2153590|PMID:11574540)
Ensembl
RGD
PMID:11574540, PMID:11683876 GO_REF:0000107, MGI:MGI:2153590, RGD:727326 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
G Xbp1 X-box binding protein 1 ISO (PMID:23529610) RGD PMID:23529610 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
negative regulation of vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadm4 cell adhesion molecule 4 ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:6271409|PMID:25893857)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:25893857 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6271409 NCBI chr 1:81,365,200...81,369,841
Ensembl chr 1:81,365,138...81,370,109
JBrowse link
G Cnmd chondromodulin ISO
IBA
MGI:MGI:2448465 (MGI:MGI:3690798|PMID:16980969)
PMID:21873635
RGD PMID:16980969, PMID:21873635 MGI:MGI:3690798, RGD:13792537 NCBI chr15:61,923,291...61,947,840
Ensembl chr15:61,923,299...61,947,764
JBrowse link
G Dab2ip DAB2 interacting protein IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3831615|PMID:19033661)
(PMID:19033661)
GO_REF:0000002
Ensembl
UniProt
RGD
InterPro
PMID:19033661 GO_REF:0000002, GO_REF:0000024, GO_REF:0000107, MGI:MGI:3831615 NCBI chr 3:14,889,263...15,060,286
Ensembl chr 3:14,889,510...15,060,286
JBrowse link
G Emilin1 elastin microfibril interfacer 1 ISO (MGI:MGI:5605894|PMID:25056700) RGD PMID:25056700 MGI:MGI:5605894 NCBI chr 6:26,821,249...26,829,013
Ensembl chr 6:26,821,255...26,828,972
JBrowse link
G Epn2 epsin 2 IEA
ISO
GO_REF:0000107
(PMID:28717225)
Ensembl
RGD
PMID:28717225 GO_REF:0000107 NCBI chr10:47,795,496...47,857,373
Ensembl chr10:47,795,524...47,857,326
JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate IEA
ISO
GO_REF:0000107
(PMID:18977327)
Ensembl
RGD
PMID:18977327 GO_REF:0000107 NCBI chr10:109,638,944...109,657,460
Ensembl chr10:109,638,767...109,657,456
JBrowse link
G Hhex hematopoietically expressed homeobox ISO (MGI:MGI:3777525|PMID:12588764) RGD PMID:12588764 MGI:MGI:3777525 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649
JBrowse link
G Mmrn2 multimerin 2 ISO
IBA
(PMID:22020326)
PMID:21873635
RGD PMID:22020326, PMID:21873635 RGD:13792537 NCBI chr16:10,727,552...10,749,303
Ensembl chr16:10,727,571...10,749,382
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:4441129|PMID:15060076)
Ensembl
UniProt
RGD
PMID:15060076 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4441129 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
JBrowse link
G Pdcd6 programmed cell death 6 ISO (PMID:21893193) RGD PMID:21893193 NCBI chr 1:31,576,183...31,591,852
Ensembl chr 1:31,576,183...31,591,849
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO UniProtKB:P97333 (MGI:MGI:5490930|PMID:23639442) RGD PMID:23639442 MGI:MGI:5490930 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Tnmd tenomodulin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:104,684,676...104,700,173
Ensembl chr  X:104,684,676...104,700,173
JBrowse link
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspb1 heat shock protein family B (small) member 1 ISO
IEA
(PMID:18440775)
GO_REF:0000107
RGD
Ensembl
PMID:18440775 GO_REF:0000107 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Kdr kinase insert domain receptor ISO
IEA
(PMID:21885851)
GO_REF:0000107
RGD
Ensembl
PMID:21885851 GO_REF:0000107 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Prkd1 protein kinase D1 ISO UniProtKB:Q9BZL6 (PMID:18440775), (PMID:20497126) RGD PMID:18440775, PMID:20497126 NCBI chr 6:71,035,017...71,349,531
Ensembl chr 6:71,035,332...71,349,249
JBrowse link
G Prkd2 protein kinase D2 ISO UniProtKB:Q15139 (PMID:18440775), (PMID:20497126) RGD PMID:18440775, PMID:20497126 NCBI chr 1:78,767,911...78,796,223
Ensembl chr 1:78,767,911...78,796,231
JBrowse link
G Vegfa vascular endothelial growth factor A ISO (PMID:18440775), (PMID:20497126), (PMID:21245381) RGD PMID:18440775, PMID:20497126, PMID:21245381 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
positive regulation of vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 ISO MGI:MGI:3629660 (MGI:MGI:3716020|PMID:17560563) RGD PMID:17560563 MGI:MGI:3716020 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Fgf18 fibroblast growth factor 18 ISO
IEA
MGI:MGI:2178751 (MGI:MGI:3703411|PMID:17014841)
GO_REF:0000107
RGD
Ensembl
PMID:17014841 GO_REF:0000107, MGI:MGI:3703411 NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391
JBrowse link
G Fgf9 fibroblast growth factor 9 ISO MGI:MGI:2135961 (MGI:MGI:3716021|PMID:17544391) RGD PMID:17544391 MGI:MGI:3716021 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Grb10 growth factor receptor bound protein 10 ISO
ISS
(PMID:15060076)
GO_REF:0000024
RGD
UniProt
PMID:15060076 GO_REF:0000024 NCBI chr14:92,021,851...92,122,249
Ensembl chr14:92,021,851...92,117,923
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO
IEA
MGI:MGI:2386649|MGI:MGI:2386679 (MGI:MGI:2153426|PMID:11691837)
GO_REF:0000107
RGD
Ensembl
PMID:11691837 GO_REF:0000107, MGI:MGI:2153426 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Mt3 metallothionein 3 ISO
ISS
(PMID:18295594)
GO_REF:0000024
RGD
UniProt
PMID:18295594 GO_REF:0000024 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Prkcb protein kinase C, beta IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:2157264|PMID:11805327)
Ensembl
UniProt
RGD
PMID:11805327 GO_REF:0000024, GO_REF:0000107, MGI:MGI:2157264 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkd2 protein kinase D2 ISO
ISS
(PMID:19001381)
GO_REF:0000024
RGD
UniProt
PMID:19001381 GO_REF:0000024 NCBI chr 1:78,767,911...78,796,223
Ensembl chr 1:78,767,911...78,796,231
JBrowse link
G Vegfb vascular endothelial growth factor B ISO (PMID:18259607) RGD PMID:18259607 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link
regulation of vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd4 frizzled class receptor 4 ISO MGI:MGI:2387667 (MGI:MGI:3692134|PMID:16093361) RGD PMID:16093361 MGI:MGI:3692134 NCBI chr 1:153,589,471...153,598,376
Ensembl chr 1:153,589,471...153,598,375
JBrowse link
G Myof myoferlin ISO (MGI:MGI:4821066|PMID:17702744) RGD PMID:17702744 MGI:MGI:4821066 NCBI chr 1:256,585,410...256,734,727
Ensembl chr 1:256,585,410...256,734,730
JBrowse link
G Tmem204 transmembrane protein 204 ISO
IBA
MGI:MGI:95561|MGI:MGI:96683 (MGI:MGI:4443218|PMID:20439428)
PMID:21873635
RGD PMID:20439428, PMID:21873635 MGI:MGI:4443218, RGD:13792537 NCBI chr10:14,417,608...14,446,272
Ensembl chr10:14,417,609...14,443,010
JBrowse link
G Vegfc vascular endothelial growth factor C IMP RGD PMID:11683876 RGD:727326 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Vegfd vascular endothelial growth factor D IMP RGD PMID:11683876 RGD:727326 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
vascular endothelial growth factor receptor-1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt1 Fms related receptor tyrosine kinase 1 IEA
ISO
GO_REF:0000107
(PMID:15952180)
Ensembl
RGD
PMID:15952180 GO_REF:0000107 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
vascular endothelial growth factor receptor-2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec14a C-type lectin domain containing 14A ISO MGI:MGI:6404416 (MGI:MGI:5881854|PMID:27991863)
(PMID:27991863)
RGD PMID:27991863 MGI:MGI:5881854 NCBI chr 6:79,303,301...79,306,443
Ensembl chr 6:79,303,304...79,306,443
JBrowse link
G Dab2ip DAB2 interacting protein IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3831615|PMID:19033661)
Ensembl
UniProt
RGD
PMID:19033661 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3831615 NCBI chr 3:14,889,263...15,060,286
Ensembl chr 3:14,889,510...15,060,286
JBrowse link
G Kdr kinase insert domain receptor IEA
ISO
GO_REF:0000107
(PMID:24205206)
Ensembl
RGD
PMID:24205206 GO_REF:0000107 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Pdcd6 programmed cell death 6 ISO (PMID:21893193) RGD PMID:21893193 NCBI chr 1:31,576,183...31,591,852
Ensembl chr 1:31,576,183...31,591,849
JBrowse link
G Vegfa vascular endothelial growth factor A ISO (PMID:23688497) RGD PMID:23688497 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
vascular endothelial growth factor receptor-3 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec14a C-type lectin domain containing 14A ISO MGI:MGI:6404416 (MGI:MGI:5881854|PMID:27991863)
(PMID:27991863)
RGD PMID:27991863 MGI:MGI:5881854 NCBI chr 6:79,303,301...79,306,443
Ensembl chr 6:79,303,304...79,306,443
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    signaling 7588
      signal transduction 7015
        cell surface receptor signaling pathway 2782
          enzyme linked receptor protein signaling pathway 963
            transmembrane receptor protein tyrosine kinase signaling pathway 605
              vascular endothelial growth factor receptor signaling pathway 44
                negative regulation of vascular endothelial growth factor receptor signaling pathway 12
                positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway 5
                positive regulation of vascular endothelial growth factor receptor signaling pathway 9
                regulation of vascular endothelial growth factor receptor signaling pathway + 26
                vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment 0
                vascular endothelial growth factor receptor-1 signaling pathway 1
                vascular endothelial growth factor receptor-2 signaling pathway 5
                vascular endothelial growth factor receptor-3 signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            cell surface receptor signaling pathway 2782
              enzyme linked receptor protein signaling pathway 963
                transmembrane receptor protein tyrosine kinase signaling pathway 605
                  vascular endothelial growth factor receptor signaling pathway 44
                    negative regulation of vascular endothelial growth factor receptor signaling pathway 12
                    positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway 5
                    positive regulation of vascular endothelial growth factor receptor signaling pathway 9
                    regulation of vascular endothelial growth factor receptor signaling pathway + 26
                    vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment 0
                    vascular endothelial growth factor receptor-1 signaling pathway 1
                    vascular endothelial growth factor receptor-2 signaling pathway 5
                    vascular endothelial growth factor receptor-3 signaling pathway 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.