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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of fibroblast proliferation
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Accession:GO:0048146 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
Synonyms:exact_synonym: up regulation of fibroblast proliferation;   upregulation of fibroblast proliferation
 narrow_synonym: activation of fibroblast proliferation;   stimulation of fibroblast proliferation


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positive regulation of fibroblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase IMP RGD PMID:19846571 RGD:8693597 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Ager advanced glycosylation end product-specific receptor IMP RGD PMID:23053478 RGD:7244384 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Agt angiotensinogen IDA PMID:8348686 BHF-UCL PMID:8348686 RGD:8553767 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Anxa2 annexin A2 IMP RGD PMID:19193640 RGD:7242275 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Aqp1 aquaporin 1 ISO
ISS
(PMID:16565507)
GO_REF:0000024
RGD
UniProt
PMID:16565507 GO_REF:0000024 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger ISO (PMID:17420273) RGD PMID:17420273 NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208
JBrowse link
G Btc betacellulin IDA RGD PMID:15862140 RGD:2306976 NCBI chr14:18,231,854...18,270,621
Ensembl chr14:18,231,860...18,272,484
JBrowse link
G Ccna2 cyclin A2 IMP RGD PMID:15737994 RGD:2293349 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 ISO (MGI:MGI:5494393|PMID:22053081) RGD PMID:22053081 MGI:MGI:5494393 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cd74 CD74 molecule ISO (PMID:12782713) RGD PMID:12782713 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cdc6 cell division cycle 6 IDA RGD PMID:22223646 RGD:10045360 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdk4 cyclin-dependent kinase 4 ISO (PMID:17420273) RGD PMID:17420273 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 ISO (PMID:17420273) RGD PMID:17420273 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO (PMID:17420273) RGD PMID:17420273 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ctc1 CST telomere replication complex component 1 ISO MGI:MGI:5427642 (MGI:MGI:5426340|PMID:22531781) RGD PMID:22531781 MGI:MGI:5426340 NCBI chr10:55,596,172...55,616,873
Ensembl chr10:55,596,148...55,616,889
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 ISO (MGI:MGI:2158097|PMID:11723120), (MGI:MGI:2158837|PMID:11375938) RGD PMID:11375938, PMID:11723120 MGI:MGI:2158097, MGI:MGI:2158837 NCBI chr13:88,311,639...88,436,561
Ensembl chr13:88,317,145...88,436,789
JBrowse link
G Dhx9 DExH-box helicase 9 ISO (PMID:24990949) RGD PMID:24990949 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G E2f1 E2F transcription factor 1 ISO (PMID:20224733) RGD PMID:20224733 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Egf epidermal growth factor IDA RGD PMID:3093142 RGD:10395243 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor ISO (MGI:MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:MGI:4887523 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Ereg epiregulin ISO
ISS
(PMID:12702554)
GO_REF:0000024
RGD
UniProt
PMID:12702554 GO_REF:0000024 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Esr1 estrogen receptor 1 ISO
IEA
MGI:MGI:2150897 (MGI:MGI:3839071|PMID:18755802)
GO_REF:0000107
RGD
Ensembl
PMID:18755802 GO_REF:0000107, MGI:MGI:3839071 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fbln1 fibulin 1 ISO (PMID:25834989) RGD PMID:25834989 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fbrs fibrosin ISO (MGI:MGI:71754|PMID:7892239) RGD PMID:7892239 MGI:MGI:71754 NCBI chr 1:198,925,265...198,938,939
Ensembl chr 1:198,932,870...198,937,750
JBrowse link
G Fgf10 fibroblast growth factor 10 ISO MGI:MGI:1859647 (MGI:MGI:3040788|PMID:15130516) RGD PMID:15130516 MGI:MGI:3040788 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 NOT IDA adventitial fibroblasts of the thoracic aorta RGD PMID:17651752 RGD:2289969 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fn1 fibronectin 1 IEA
ISO
GO_REF:0000107
(PMID:25834989)
Ensembl
RGD
PMID:25834989 GO_REF:0000107 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fndc3b fibronectin type III domain containing 3B ISO MGI:MGI:4822558 (MGI:MGI:4822563|PMID:19138685) RGD PMID:19138685 MGI:MGI:4822563 NCBI chr 2:113,109,949...113,415,171
Ensembl chr 2:113,112,902...113,345,577
JBrowse link
G Fntb farnesyltransferase, CAAX box, beta ISO MGI:MGI:3581448 (MGI:MGI:3580759|PMID:15837621) RGD PMID:15837621 MGI:MGI:3580759 NCBI chr 6:99,883,959...99,966,988
Ensembl chr 6:99,883,959...99,966,988
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit ISO (MGI:MGI:69186|PMID:7936655) RGD PMID:7936655 MGI:MGI:69186 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Gas6 growth arrest specific 6 ISS
ISO
GO_REF:0000024
(PMID:15184064), (PMID:7854420)
UniProt
RGD
PMID:7854420, PMID:15184064 GO_REF:0000024 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP cardiac fibroblast RGD PMID:27862165 RGD:13513991 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Igf1 insulin-like growth factor 1 ISO
IEA
(PMID:7188854)
GO_REF:0000107
RGD
Ensembl
PMID:7188854 GO_REF:0000107 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Itgb3 integrin subunit beta 3 ISO MGI:MGI:2175913 (MGI:MGI:5462513|PMID:22984613) RGD PMID:22984613 MGI:MGI:5462513 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO MGI:MGI:1277991 (MGI:MGI:3719935|PMID:17182846) RGD PMID:17182846 MGI:MGI:3719935 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kmt2c lysine methyltransferase 2C ISO MGI:MGI:3693319 (MGI:MGI:3692812|PMID:17021013) RGD PMID:17021013 MGI:MGI:3692812 NCBI chr 4:82,506...109,986
NCBI chr 4:6,083,650...6,294,413
Ensembl chr 4:6,083,736...6,292,516
JBrowse link
G Kng2 kininogen 2 IDA in 3T3 cells exposed exogenously RGD PMID:15664626 RGD:1600455 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lig4 DNA ligase 4 ISO MGI:MGI:1857732 (MGI:MGI:1312981|PMID:9823897), (MGI:MGI:1860400|PMID:10911993) RGD PMID:9823897, PMID:10911993 MGI:MGI:1312981, MGI:MGI:1860400 NCBI chr16:85,331,771...85,339,496
Ensembl chr16:85,331,866...85,337,769
JBrowse link
G Mif macrophage migration inhibitory factor ISO (MGI:MGI:4437204|PMID:10364264)
(PMID:12782713)
RGD PMID:10364264, PMID:12782713 MGI:MGI:4437204 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mir223 microRNA 223 IMP RGD PMID:29689569 RGD:25823140 NCBI chr  X:65,367,812...65,367,921
Ensembl chr  X:65,367,812...65,367,921
JBrowse link
G Mir433 microRNA 433 IDA RGD PMID:27698941 RGD:14700802 NCBI chr 6:133,712,334...133,712,426
Ensembl chr 6:133,712,334...133,712,426
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IMP
ISO
ISS
(PMID:15674325), (PMID:18987311), (PMID:9924025)
GO_REF:0000024
RGD
UniProt
PMID:9924025, PMID:15674325, PMID:18987311, PMID:22842522 GO_REF:0000024, RGD:7207891 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 ISO (PMID:16478720) RGD PMID:16478720 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Ngfr nerve growth factor receptor ISO MGI:MGI:1857226 (MGI:MGI:1350519|PMID:10588868) RGD PMID:10588868 MGI:MGI:1350519 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO (MGI:MGI:5529589|PMID:23871832) RGD PMID:23871832 MGI:MGI:5529589 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Pdgfa platelet derived growth factor subunit A IEA
ISO
ISS
GO_REF:0000107
(PMID:10806482), (PMID:2439522)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:2439522, PMID:10806482 GO_REF:0000024, GO_REF:0000107 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdgfb platelet derived growth factor subunit B IEA
ISO
ISS
GO_REF:0000107
(PMID:10644978), (PMID:17324121), (PMID:2439522)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:2439522, PMID:10644978, PMID:17324121 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdgfc platelet derived growth factor C ISO (PMID:10806482) RGD PMID:10806482 NCBI chr 2:179,952,227...180,126,897
Ensembl chr 2:179,952,227...180,128,283
JBrowse link
G Pdgfd platelet derived growth factor D IDA RGD PMID:21866094 RGD:9854633 NCBI chr 8:4,441,010...4,666,754
Ensembl chr 8:4,440,876...4,669,014
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha ISO
IEA
ISS
(PMID:10806482)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:10806482 GO_REF:0000024, GO_REF:0000107 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IMP RGD PMID:18466260 RGD:10449503 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pla2g1b phospholipase A2 group IB ISO
IBA
(PMID:1918029)
PMID:21873635
RGD PMID:1918029, PMID:21873635 RGD:13792537 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Pml PML nuclear body scaffold ISO (MGI:MGI:5502477|PMID:23555679) RGD PMID:23555679 MGI:MGI:5502477 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 IDA RGD PMID:9705269 RGD:9589122 NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
JBrowse link
G Rasa1 RAS p21 protein activator 1 IMP RGD PMID:7588705 RGD:10002727 NCBI chr 2:13,617,021...13,696,531
Ensembl chr 2:13,616,822...13,696,426
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 IMP RGD PMID:15798216 RGD:10003119 NCBI chr 8:97,277,250...97,405,095
Ensembl chr 8:97,277,456...97,405,102
JBrowse link
G Rnaseh2b ribonuclease H2, subunit B ISO MGI:MGI:4432164 (MGI:MGI:5435090|PMID:22802351) RGD PMID:22802351 MGI:MGI:5435090 NCBI chr15:45,422,010...45,472,792
Ensembl chr15:45,422,010...45,464,892
JBrowse link
G Rps3a ribosomal protein S3a IMP RGD PMID:8877097 RGD:11040965 NCBI chr 2:185,440,477...185,444,846
Ensembl chr 2:185,440,291...185,444,897
JBrowse link
G Serpine1 serpin family E member 1 IMP RGD PMID:22659625 RGD:8547927 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sirt6 sirtuin 6 ISO (MGI:MGI:3663736|PMID:16439206) RGD PMID:16439206 MGI:MGI:3663736 NCBI chr 7:10,937,622...10,943,048
Ensembl chr 7:10,937,599...10,943,063
JBrowse link
G Sphk1 sphingosine kinase 1 ISO
IEA
(PMID:15623571)
GO_REF:0000107
RGD
Ensembl
PMID:15623571 GO_REF:0000107 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Tdgf1 teratocarcinoma-derived growth factor 1 ISO MGI:MGI:1857518 (MGI:MGI:1321047|PMID:9876177) RGD PMID:9876177 MGI:MGI:1321047 NCBI chr 8:119,215,266...119,220,909
Ensembl chr 8:119,215,495...119,219,232
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO (MGI:MGI:5529589|PMID:23871832) RGD PMID:23871832 MGI:MGI:5529589 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 ISO MGI:MGI:3652354 (MGI:MGI:3629366|PMID:16705179) RGD PMID:16705179 MGI:MGI:3629366 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:17184580 RGD:2306814 NCBI chr 5:168,078,748...168,084,133
Ensembl chr 5:168,078,748...168,084,145
JBrowse link
G Uts2r urotensin 2 receptor IMP RGD PMID:16919371 RGD:2306833 NCBI chr10:110,364,291...110,365,451
Ensembl chr10:110,364,291...110,365,451
JBrowse link
G Wapl WAPL cohesin release factor ISO MGI:MGI:5551807 (MGI:MGI:5544860|PMID:23975099) RGD PMID:23975099 MGI:MGI:5544860 NCBI chr16:11,029,325...11,108,867
Ensembl chr16:11,032,531...11,106,589
JBrowse link
G Wnt1 Wnt family member 1 ISO (PMID:19734317) RGD PMID:19734317 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link
G Wnt2 Wnt family member 2 ISO (PMID:19734317) RGD PMID:19734317 NCBI chr 4:45,286,845...45,332,899
Ensembl chr 4:45,292,437...45,332,420
JBrowse link
G Wnt5a Wnt family member 5A IEA
ISO
GO_REF:0000107
(PMID:19251946)
Ensembl
RGD
PMID:19251946 GO_REF:0000107 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 ISO MGI:MGI:1926771 (MGI:MGI:1913213|PMID:9875844) RGD PMID:9875844 MGI:MGI:1913213 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link
G Zmiz1 zinc finger, MIZ-type containing 1 ISO MGI:MGI:3769389 (MGI:MGI:3768282|PMID:17967885) RGD PMID:17967885 MGI:MGI:3768282 NCBI chr16:1,749,191...1,954,633
Ensembl chr16:1,749,191...1,954,614
JBrowse link
positive regulation of hepatic stellate cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myb MYB proto-oncogene, transcription factor IMP RGD PMID:15534927 RGD:11532676 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Pdgfb platelet derived growth factor subunit B IMP RGD PMID:15358192 RGD:10449487 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
positive regulation of pancreatic stellate cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 IDA RGD PMID:20100461 RGD:4145466 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    positive regulation of biological process 6652
      positive regulation of cellular process 6149
        positive regulation of cell population proliferation 1064
          positive regulation of fibroblast proliferation 75
            positive regulation of hepatic stellate cell proliferation 2
            positive regulation of pancreatic stellate cell proliferation 1
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        positive regulation of biological process 6652
          positive regulation of cellular process 6149
            positive regulation of cell population proliferation 1064
              positive regulation of fibroblast proliferation 75
                positive regulation of hepatic stellate cell proliferation 2
                positive regulation of pancreatic stellate cell proliferation 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.