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ONTOLOGY REPORT - ANNOTATIONS


Term:sperm capacitation
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Accession:GO:0048240 term browser browse the term
Definition:A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
Comment:Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract.
Synonyms:related_synonym: sperm activation


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sperm capacitation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase ISO
IBA
(PMID:26989199)
PMID:21873635
RGD PMID:26989199, PMID:21873635 RGD:13792537 NCBI chr 1:140,998,240...141,087,405
Ensembl chr 1:140,998,240...141,087,405
JBrowse link
G Bsph1 binder of sperm protein homolog 1 ISO
IBA
(MGI:MGI:5465085|PMID:22539676)
PMID:21873635
RGD PMID:22539676, PMID:21873635 MGI:MGI:5465085, RGD:13792537 NCBI chr 1:75,705,172...75,793,950
Ensembl chr 1:75,748,916...75,789,785
JBrowse link
G Bsph2 binder of sperm protein homolog 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:75,837,911...75,849,781
Ensembl chr 1:75,842,073...75,849,658
JBrowse link
G Cabyr calcium binding tyrosine phosphorylation regulated IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:4,082,175...4,096,650
Ensembl chr18:4,084,228...4,095,936
JBrowse link
G Catsper2 cation channel, sperm associated 2 ISO
IBA
MGI:MGI:2683843 (MGI:MGI:2682517|PMID:14657366)
PMID:21873635
RGD PMID:14657366, PMID:21873635 MGI:MGI:2682517, RGD:13792537 NCBI chr 3:113,357,361...113,379,498
Ensembl chr 3:113,357,365...113,376,751
JBrowse link
G Catsper3 cation channel, sperm associated 3 ISO
IBA
MGI:MGI:3694352 (MGI:MGI:3694233|PMID:17227845)
PMID:21873635
RGD PMID:17227845, PMID:21873635 MGI:MGI:3694233, RGD:13792537 NCBI chr17:8,900,034...8,925,385
Ensembl chr17:8,900,036...8,925,503
JBrowse link
G Catsper4 cation channel, sperm associated 4 ISO
IBA
MGI:MGI:3694354 (MGI:MGI:3694233|PMID:17227845)
PMID:21873635
RGD PMID:17227845, PMID:21873635 MGI:MGI:3694233, RGD:13792537 NCBI chr 5:152,430,052...152,446,808
Ensembl chr 5:152,430,025...152,446,775
JBrowse link
G Catsperd cation channel sperm associated auxiliary subunit delta ISO
ISS
(MGI:MGI:5315675|PMID:21224844)
GO_REF:0000024
RGD
UniProt
PMID:21224844 GO_REF:0000024, MGI:MGI:5315675 NCBI chr 9:10,390,307...10,428,666
Ensembl chr 9:10,390,308...10,427,746
JBrowse link
G Catsperz catsper channel auxiliary subunit zeta IBA
ISO
PMID:21873635
(MGI:MGI:5825443|PMID:28226241), (MGI:MGI:6316499|PMID:31056283)
RGD PMID:28226241, PMID:31056283, PMID:21873635 MGI:MGI:5825443, MGI:MGI:6316499, RGD:13792537 NCBI chr 1:222,179,451...222,182,716
Ensembl chr 1:222,179,436...222,182,721
JBrowse link
G Cftr CF transmembrane conductance regulator IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5429843|PMID:21976599)
Ensembl
UniProt
RGD
PMID:21976599 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5429843 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO (MGI:MGI:3589712|PMID:15888450) RGD PMID:15888450 MGI:MGI:3589712 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Efcab9 EF-hand calcium binding domain 9 ISO
IBA
(MGI:MGI:6316499|PMID:31056283)
PMID:21873635
RGD PMID:31056283, PMID:21873635 MGI:MGI:6316499, RGD:13792537 NCBI chr10:17,399,291...17,406,915
Ensembl chr10:17,407,979...17,415,251
JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 IEA
ISO
ISS
GO_REF:0000107
MGI:MGI:2665512 (MGI:MGI:3619873|PMID:16371590), (MGI:MGI:5784979|PMID:21302280), (MGI:MGI:5784984|PMID:19342015)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:16371590, PMID:19342015, PMID:21302280 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3619873, MGI:MGI:5784979, MGI:MGI:5784984 NCBI chr 7:12,247,498...12,255,721
Ensembl chr 7:12,247,498...12,255,719
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 ISO (MGI:MGI:3603744|PMID:16183867) RGD PMID:16183867 MGI:MGI:3603744 NCBI chr12:45,026,948...45,031,148
Ensembl chr12:45,026,886...45,031,145
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha IEA
ISO
GO_REF:0000107
(MGI:MGI:4357734|PMID:19560455)
Ensembl
RGD
PMID:19560455 GO_REF:0000107, MGI:MGI:4357734 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Ropn1 rhophilin associated tail protein 1 ISO
IBA
ISS
MGI:MGI:4144733 (MGI:MGI:5551621|PMID:23303679)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23303679, PMID:21873635 GO_REF:0000024, MGI:MGI:5551621, RGD:13792537 NCBI chr11:69,326,785...69,355,788
Ensembl chr11:69,326,719...69,355,854
JBrowse link
G Ropn1l rhophilin associated tail protein 1-like ISO
IBA
MGI:MGI:4143866 (MGI:MGI:5551621|PMID:23303679)
PMID:21873635
RGD PMID:23303679, PMID:21873635 MGI:MGI:5551621, RGD:13792537 NCBI chr 2:84,520,421...84,531,192
Ensembl chr 2:84,520,421...84,531,342
JBrowse link
G Semg1 semenogelin 1 ISO
IBA
(MGI:MGI:3709410|PMID:17123940)
PMID:21873635
RGD PMID:17123940, PMID:21873635 MGI:MGI:3709410, RGD:13792537 NCBI chr 3:160,627,609...160,630,457
Ensembl chr 3:160,627,610...160,630,457
JBrowse link
G Septin4 septin 4 ISO MGI:MGI:3574368 (MGI:MGI:3531234|PMID:15737931) RGD PMID:15737931 MGI:MGI:3531234 NCBI chr10:74,860,068...74,884,196
Ensembl chr10:74,861,714...74,884,196
JBrowse link
G Slc26a3 solute carrier family 26 member 3 ISO
ISS
(MGI:MGI:5429843|PMID:21976599)
GO_REF:0000024
RGD
UniProt
PMID:21976599 GO_REF:0000024, MGI:MGI:5429843 NCBI chr 6:50,725,085...50,766,306
Ensembl chr 6:50,725,085...50,766,300
JBrowse link
G Slc26a6 solute carrier family 26 member 6 ISO (MGI:MGI:5429843|PMID:21976599) RGD PMID:21976599 MGI:MGI:5429843 NCBI chr 8:117,648,792...117,659,376
Ensembl chr 8:117,648,745...117,659,804
JBrowse link
G Slc26a8 solute carrier family 26 member 8 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:5,870,714...5,933,151
Ensembl chr20:5,881,462...5,931,648
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 ISO (MGI:MGI:5428115|PMID:22228629) RGD PMID:22228629 MGI:MGI:5428115 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Svs3b seminal vesicle secretory protein 3B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:159,082,346...159,084,621 JBrowse link
negative regulation of sperm capacitation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Paep progestagen associated endometrial protein ISO (PMID:15883155) RGD PMID:15883155 NCBI chr 3:2,935,396...2,938,883 JBrowse link
positive regulation of flagellated sperm motility involved in capacitation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 ISO (PMID:23765988)
(MGI:MGI:5784973|PMID:23765988)
RGD PMID:23765988 MGI:MGI:5784973 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Defb1 defensin beta 1 ISO
ISS
(PMID:25122636)
GO_REF:0000024
RGD
UniProt
PMID:25122636 GO_REF:0000024 NCBI chr16:75,294,385...75,309,127
Ensembl chr16:75,294,376...75,309,176
JBrowse link
G Iqcf1 IQ motif containing F1 ISO (MGI:MGI:5708001|PMID:25380116) RGD PMID:25380116 MGI:MGI:5708001 NCBI chr 8:115,191,919...115,195,599
Ensembl chr 8:115,193,146...115,195,668
JBrowse link
G Rnase9 ribonuclease A family member 9 ISO MGI:MGI:5637811 (MGI:MGI:5582126|PMID:24719258) RGD PMID:24719258 MGI:MGI:5582126 NCBI chr15:27,964,000...27,968,492
Ensembl chr15:27,964,804...27,968,358
JBrowse link
regulation of sperm capacitation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tcp11 t-complex 11 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(MGI:MGI:1097498|PMID:9322250), (MGI:MGI:5816449|PMID:9820206)
UniProt
RGD
PMID:9322250, PMID:9820206, PMID:21873635 GO_REF:0000024, MGI:MGI:1097498, MGI:MGI:5816449, RGD:13792537 NCBI chr20:7,645,619...7,657,222
Ensembl chr20:7,645,626...7,654,428
JBrowse link
G Tcp11x2 t-complex 11 family, X-linked 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:106,104,501...106,187,190
Ensembl chr  X:106,104,705...106,116,886
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    reproductive process 1797
      cellular process involved in reproduction in multicellular organism 464
        sperm capacitation 31
          negative regulation of sperm capacitation 1
          positive regulation of actin filament polymerization involved in sperm capacitation 0
          positive regulation of flagellated sperm motility involved in capacitation 4
          positive regulation of sperm capacitation 0
          regulation of sperm capacitation + 3
Path 2
Term Annotations click to browse term
  biological_process 20027
    reproduction 1800
      reproductive process 1797
        multi-organism reproductive process 1248
          sexual reproduction 992
            gamete generation 821
              male gamete generation 622
                spermatogenesis 601
                  spermatid differentiation 210
                    spermatid development 202
                      sperm capacitation 31
                        negative regulation of sperm capacitation 1
                        positive regulation of actin filament polymerization involved in sperm capacitation 0
                        positive regulation of flagellated sperm motility involved in capacitation 4
                        positive regulation of sperm capacitation 0
                        regulation of sperm capacitation + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.