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ONTOLOGY REPORT - ANNOTATIONS


Term:sperm capacitation
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Accession:GO:0048240 term browser browse the term
Definition:A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
Comment:Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract.
Synonyms:related_synonym: sperm activation


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sperm capacitation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd2 abhydrolase domain containing 2 JBrowse link 1 140,998,240 141,087,405 RGD:1624291
RGD:13792537
G Bsph1 binder of sperm protein homolog 1 JBrowse link 1 75,705,172 75,793,950 RGD:1624291
RGD:13792537
G Cabyr calcium binding tyrosine phosphorylation regulated JBrowse link 18 4,082,175 4,096,650 RGD:1600115
G Catsper2 cation channel, sperm associated 2 JBrowse link 3 113,357,361 113,379,498 RGD:1624291
RGD:13792537
G Catsper3 cation channel, sperm associated 3 JBrowse link 17 8,900,034 8,925,385 RGD:1624291
RGD:1600115
G Catsper4 cation channel, sperm associated 4 JBrowse link 5 152,430,052 152,446,808 RGD:1624291
RGD:1600115
G Catsperd cation channel sperm associated auxiliary subunit delta JBrowse link 9 10,390,307 10,428,666 RGD:1624291
RGD:1600115
G Catsperz catsper channel auxiliary subunit zeta JBrowse link 1 222,179,451 222,182,716 RGD:13792537
RGD:1624291
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:1600115
RGD:1624291
G Dld dihydrolipoamide dehydrogenase JBrowse link 6 50,597,677 50,618,694 RGD:1624291
RGD:1600115
G Efcab9 EF-hand calcium binding domain 9 JBrowse link 10 17,399,291 17,406,915 RGD:1600115
RGD:1624291
G Pcsk4 proprotein convertase subtilisin/kexin type 4 JBrowse link 7 12,247,498 12,255,721 RGD:1600115
RGD:1624291
G Pebp1 phosphatidylethanolamine binding protein 1 JBrowse link 12 45,026,948 45,031,148 RGD:1624291
RGD:1600115
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:1600115
RGD:1624291
G Ropn1 rhophilin associated tail protein 1 JBrowse link 11 69,326,785 69,355,788 RGD:1624291
RGD:1600115
G Ropn1l rhophilin associated tail protein 1-like JBrowse link 2 84,520,421 84,531,192 RGD:1624291
RGD:1600115
G Semg1 semenogelin 1 JBrowse link 3 160,627,609 160,630,457 RGD:1624291
RGD:13792537
G Septin4 septin 4 JBrowse link 10 74,860,068 74,884,196 RGD:1624291
G Slc26a3 solute carrier family 26 member 3 JBrowse link 6 50,725,085 50,766,306 RGD:1624291
RGD:1600115
G Slc26a6 solute carrier family 26 member 6 JBrowse link 8 117,648,792 117,659,376 RGD:1624291
G Slc26a8 solute carrier family 26 member 8 JBrowse link 20 5,870,714 5,933,151 RGD:1600115
G Spink1 serine peptidase inhibitor, Kazal type 1 JBrowse link 18 38,221,919 38,242,092 RGD:1624291
G Svs3b seminal vesicle secretory protein 3B JBrowse link 3 159,082,346 159,084,621 RGD:13792537
negative regulation of sperm capacitation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lcn11 lipocalin 11 JBrowse link 3 2,935,396 2,938,883 RGD:1624291
positive regulation of flagellated sperm motility involved in capacitation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr6 C-C motif chemokine receptor 6 JBrowse link 1 53,063,380 53,087,519 RGD:1624291
RGD:1600115
G Defb1 defensin beta 1 JBrowse link 16 75,294,385 75,309,127 RGD:1624291
RGD:1600115
G Iqcf1 IQ motif containing F1 JBrowse link 8 115,191,919 115,195,599 RGD:1624291
RGD:1600115
G Rnase9 ribonuclease A family member 9 JBrowse link 15 27,964,000 27,968,492 RGD:1624291
regulation of sperm capacitation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tcp11 t-complex 11 JBrowse link 20 7,645,619 7,657,222 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18179
    cellular process 16288
      cellular process involved in reproduction in multicellular organism 418
        sperm capacitation 29
          negative regulation of sperm capacitation 1
          positive regulation of actin filament polymerization involved in sperm capacitation 0
          positive regulation of flagellated sperm motility involved in capacitation 4
          positive regulation of sperm capacitation 0
          regulation of sperm capacitation + 2
Path 2
Term Annotations click to browse term
  biological_process 18179
    reproduction 1688
      reproductive process 1685
        multi-organism reproductive process 1170
          sexual reproduction 920
            gamete generation 759
              male gamete generation 590
                spermatogenesis 570
                  spermatid differentiation 197
                    spermatid development 189
                      sperm capacitation 29
                        negative regulation of sperm capacitation 1
                        positive regulation of actin filament polymerization involved in sperm capacitation 0
                        positive regulation of flagellated sperm motility involved in capacitation 4
                        positive regulation of sperm capacitation 0
                        regulation of sperm capacitation + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.