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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of receptor-mediated endocytosis
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Accession:GO:0048260 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
Synonyms:exact_synonym: up regulation of receptor mediated endocytosis;   upregulation of receptor mediated endocytosis
 narrow_synonym: activation of receptor mediated endocytosis;   stimulation of receptor mediated endocytosis


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positive regulation of receptor-mediated endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 IMP RGD PMID:11717353 RGD:13452389 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335
JBrowse link
G B2m beta-2 microglobulin ISO UniProtKB:P02787|UniProtKB:Q07891|UniProtKB:Q30201|UniProtKB:Q9UP52 (PMID:18353247) RGD PMID:18353247 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bicd1 BICD cargo adaptor 1 ISO
IBA
(PMID:20164183)
PMID:21873635
RGD PMID:20164183, PMID:21873635 RGD:13792537 NCBI chr 4:184,018,845...184,167,628
Ensembl chr 4:184,019,087...184,165,540
JBrowse link
G C3 complement C3 IEA
ISO
GO_REF:0000107
UniProtKB:P05555 (MGI:5319446|PMID:22438044), (MGI:5905548|PMID:20199584)
Ensembl
RGD
PMID:20199584, PMID:22438044 GO_REF:0000107, MGI:5319446, MGI:5905548 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Cbl Cbl proto-oncogene ISO (PMID:25178484) RGD PMID:25178484 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 ISO (MGI:2667257|PMID:12609829) RGD PMID:12609829 MGI:2667257 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 ISO (MGI:2667257|PMID:12609829) RGD PMID:12609829 MGI:2667257 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
JBrowse link
G Clu clusterin IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:11697889)
UniProtKB:C0HL13 (PMID:9228033)
Ensembl
UniProt
RGD
PMID:9228033, PMID:11697889 GO_REF:0000024, GO_REF:0000107 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G H1f1 H1.1 linker histone, cluster member ISO (MGI:5882919|PMID:9664069) RGD PMID:9664069 MGI:5882919 NCBI chr17:43,614,101...43,614,844
Ensembl chr17:43,614,101...43,614,844
JBrowse link
G Hfe homeostatic iron regulator ISO UniProtKB:P02787|UniProtKB:P61769|UniProtKB:Q07891|UniProtKB:Q9UP52 (PMID:18353247) RGD PMID:18353247 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Hip1 huntingtin interacting protein 1 ISO
IBA
(PMID:11532990), (PMID:11577110)
(MGI:2154594|PMID:11577110)
PMID:21873635
RGD PMID:11532990, PMID:11577110, PMID:21873635 MGI:2154594, RGD:13792537 NCBI chr12:24,180,795...24,315,373
Ensembl chr12:24,180,937...24,315,373
JBrowse link
G Hip1r huntingtin interacting protein 1 related IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:38,024,517...38,053,184
Ensembl chr12:38,024,519...38,053,085
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K ISO (PMID:20371611) RGD PMID:20371611 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Il4 interleukin 4 IDA
ISO
IBA
PMID:18941241
(MGI:6272248|PMID:18941241)
PMID:21873635
RGD PMID:18941241, PMID:18941241, PMID:21873635 MGI:6272248, RGD:13825436, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Kif3a kinesin family member 3a IDA RGD PMID:15181154 RGD:1581596 NCBI chr10:38,918,705...38,953,958
Ensembl chr10:38,918,748...38,952,785
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 ISO (PMID:15166224) RGD PMID:15166224 NCBI chr 5:152,964,294...152,987,286
Ensembl chr 5:152,966,591...152,987,211
JBrowse link
G Pld2 phospholipase D2 IMP RGD PMID:15470141 RGD:2299909 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 ISO
ISS
(PMID:16542649)
PMID:8895569
RGD PMID:16542649, PMID:8895569 RGD:8553248 NCBI chr 5:140,538,260...140,558,163
Ensembl chr 5:140,538,260...140,558,162
JBrowse link
G Rab21 RAB21, member RAS oncogene family ISO (PMID:15561770) RGD PMID:15561770 NCBI chr 7:58,261,985...58,286,770
Ensembl chr 7:58,261,992...58,286,770
JBrowse link
G Serpine1 serpin family E member 1 ISO
IEA
IMP
(PMID:8626514)
GO_REF:0000107
RGD
Ensembl
PMID:8626514, PMID:8626514 GO_REF:0000107, RGD:8554276 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sgip1 SH3GL interacting endocytic adaptor 1 IEA
ISO
ISS
GO_REF:0000107
(MGI:4887327|PMID:17626015)
Ensembl
RGD
PMID:17626015, PMID:17626015 GO_REF:0000107, MGI:4887327, RGD:8554282 NCBI chr 5:122,300,415...122,498,478
Ensembl chr 5:122,390,522...122,491,203
JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 IMP RGD PMID:15541315 RGD:2314546 NCBI chr 1:41,608,287...41,763,591
NCBI chr 1:41,844,840...42,086,662
Ensembl chr 1:41,608,418...42,077,535
JBrowse link
G Synj1 synaptojanin 1 IMP RGD PMID:15821731 RGD:2312450 NCBI chr11:31,105,784...31,181,573
Ensembl chr11:31,104,787...31,180,642
JBrowse link
G Tf transferrin ISO UniProtKB:Q07891|UniProtKB:Q9UP52 (PMID:12704209), (PMID:18353247) RGD PMID:12704209, PMID:18353247 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Vtn vitronectin ISO (PMID:8626514) RGD PMID:8626514 NCBI chr10:65,767,960...65,771,040
Ensembl chr10:65,767,053...65,771,038
JBrowse link
positive regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dab2 DAB adaptor protein 2 IEA
ISO
GO_REF:0000107
(MGI:5442508|PMID:16984970)
Ensembl
RGD
PMID:16984970 GO_REF:0000107, MGI:5442508 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Dgkd diacylglycerol kinase, delta ISO (PMID:17880279) RGD PMID:17880279 NCBI chr 9:94,980,328...95,071,531
Ensembl chr 9:94,980,409...95,069,714
JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:11925437 RGD:728683 NCBI chr 8:22,458,869...22,540,649
Ensembl chr 8:22,458,899...22,540,524
JBrowse link
G Scyl2 SCY1 like pseudokinase 2 ISO (PMID:19643732) RGD PMID:19643732 NCBI chr 7:30,291,087...30,344,464
Ensembl chr 7:30,291,087...30,344,445
JBrowse link
G Wasl WASP like actin nucleation promoting factor IDA PMID:20730103 BHF-UCL PMID:20730103 RGD:8554834 NCBI chr 4:51,677,722...51,726,212
Ensembl chr 4:51,677,722...51,726,212
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apln apelin IDA
ISO
PMID:11359874
(MGI:5902690|PMID:11359874)
(PMID:11359874)
RGD PMID:11359874, PMID:11359874 MGI:5902690, RGD:12907555 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G App amyloid beta precursor protein ISO (PMID:18723082) RGD PMID:18723082 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
positive regulation of receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahi1 Abelson helper integration site 1 ISS
ISO
GO_REF:0000024
(MGI:4840150|PMID:20956301)
UniProt
RGD
PMID:20956301 GO_REF:0000024, MGI:4840150 NCBI chr 1:16,478,127...16,601,769
Ensembl chr 1:16,478,127...16,601,769
JBrowse link
G Angpt1 angiopoietin 1 IEA
ISO
GO_REF:0000107
(PMID:19424712)
Ensembl
RGD
PMID:19424712 GO_REF:0000107 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 IMP RGD PMID:12105201 RGD:13461854 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Arrb1 arrestin, beta 1 ISO
ISS
(PMID:22457824)
GO_REF:0000024
RGD
UniProt
PMID:22457824 GO_REF:0000024 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 IMP
ISO
Oprm1
(PMID:22457824)
RGD PMID:22457824, PMID:16120787 RGD:5510008 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Atad1 ATPase family, AAA domain containing 1 ISS
ISO
GO_REF:0000024
(MGI:5050342|PMID:21496646)
UniProt
RGD
PMID:21496646 GO_REF:0000024, MGI:5050342 NCBI chr 1:251,234,702...251,386,996
Ensembl chr 1:251,235,508...251,387,002
JBrowse link
G Cd63 Cd63 molecule IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:23632027)
Ensembl
UniProt
RGD
PMID:23632027 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:3,320,250...3,335,583
Ensembl chr 7:3,320,103...3,335,582
JBrowse link
G Dab2 DAB adaptor protein 2 ISO (MGI:5476876|PMID:23354168) RGD PMID:23354168 MGI:5476876 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Drd2 dopamine receptor D2 IMP RGD PMID:18809670 RGD:2311559 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 IMP RGD PMID:17989303 RGD:8553895 NCBI chr17:20,090,136...20,182,332
Ensembl chr17:20,090,246...20,182,206
JBrowse link
G Egf epidermal growth factor ISO (PMID:22732145) RGD PMID:22732145 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Fmr1 FMRP translational regulator 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:25561520)
Ensembl
UniProt
RGD
PMID:25561520 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Gh1 growth hormone 1 NOT ISO (PMID:9360546) RGD PMID:9360546 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist ISO (MGI:4845816|PMID:20660291) RGD PMID:20660291 MGI:4845816 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Hamp hepcidin antimicrobial peptide ISO (PMID:15514116) RGD PMID:15514116 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Insr insulin receptor IEA
ISO
GO_REF:0000107
(PMID:25401701)
Ensembl
RGD
PMID:25401701 GO_REF:0000107 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:11526121)
Ensembl
UniProt
RGD
PMID:11526121 GO_REF:0000024, GO_REF:0000107 NCBI chr 4:10,995,241...12,472,423
Ensembl chr 4:10,995,234...11,610,518
JBrowse link
G Ntf3 neurotrophin 3 ISO
IEA
(PMID:23027130)
GO_REF:0000107
RGD
Ensembl
PMID:23027130 GO_REF:0000107 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Pard3 par-3 family cell polarity regulator ISO (MGI:5476876|PMID:23354168) RGD PMID:23354168 MGI:5476876 NCBI chr19:60,017,746...60,580,628
Ensembl chr19:60,017,746...60,580,651
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 ISO (PMID:17328821) RGD PMID:17328821 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Pick1 protein interacting with PRKCA 1 IDA
IBA
PMID:18297063
PMID:21873635
UniProt
GO_Central
PMID:18297063, PMID:21873635 RGD:8554748, RGD:13792537 NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840
JBrowse link
G Plcg2 phospholipase C, gamma 2 IEA
ISO
GO_REF:0000107
(MGI:5300392|PMID:22078883)
Ensembl
RGD
PMID:22078883 GO_REF:0000107, MGI:5300392 NCBI chr19:50,039,410...50,173,543
Ensembl chr19:50,045,020...50,173,220
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 IMP RGD PMID:19625523 RGD:9835004 NCBI chr 1:103,197,918...103,258,309
Ensembl chr 1:103,197,915...103,256,823
JBrowse link
G Scyl2 SCY1 like pseudokinase 2 ISO (PMID:19643732) RGD PMID:19643732 NCBI chr 7:30,291,087...30,344,464
Ensembl chr 7:30,291,087...30,344,445
JBrowse link
G Sele selectin E ISO
IEA
(PMID:9312078)
GO_REF:0000107
RGD
Ensembl
PMID:9312078 GO_REF:0000107 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sfrp4 secreted frizzled-related protein 4 ISO
IEA
(PMID:16151791)
GO_REF:0000107
RGD
Ensembl
PMID:16151791 GO_REF:0000107 NCBI chr17:47,383,983...47,394,065
Ensembl chr17:47,297,489...47,394,328
JBrowse link
G Syk spleen associated tyrosine kinase IEA
ISO
GO_REF:0000107
(MGI:5300392|PMID:22078883), (MGI:5619729|PMID:23962979)
Ensembl
RGD
PMID:22078883, PMID:23962979 GO_REF:0000107, MGI:5300392, MGI:5619729 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Synj2bp synaptojanin 2 binding protein ISO (MGI:3623710|PMID:16648306) RGD PMID:16648306 MGI:3623710 NCBI chr 6:105,224,166...105,261,549
Ensembl chr 6:105,224,166...105,261,549
JBrowse link
G Tbc1d5 TBC1 domain family, member 5 ISO (PMID:22354992) RGD PMID:22354992 NCBI chr 9:1,144,641...1,747,732
Ensembl chr 9:1,145,700...1,746,397
JBrowse link
G Vegfa vascular endothelial growth factor A ISO (PMID:20660291) RGD PMID:20660291 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wnt3a Wnt family member 3A ISO (PMID:16890161) RGD PMID:16890161 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
positive regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 ISO (PMID:22848640)
(MGI:5446858|PMID:22848640)
RGD PMID:22848640 MGI:5446858 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 ISO (PMID:12417523), (PMID:12464675), (PMID:15166224) RGD PMID:12417523, PMID:12464675, PMID:15166224 NCBI chr 5:152,964,294...152,987,286
Ensembl chr 5:152,966,591...152,987,211
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    positive regulation of biological process 6648
      positive regulation of transport 1086
        positive regulation of endocytosis 128
          positive regulation of receptor-mediated endocytosis 62
            positive regulation by symbiont of host receptor-mediated endocytosis 0
            positive regulation of clathrin-dependent endocytosis 5
            positive regulation of receptor internalization + 33
            positive regulation of receptor-mediated endocytosis involved in cholesterol transport 2
Path 2
Term Annotations click to browse term
  biological_process 20020
    localization 6478
      establishment of localization 4886
        transport 4734
          vesicle-mediated transport 1674
            endocytosis 683
              receptor-mediated endocytosis 254
                regulation of receptor-mediated endocytosis 123
                  positive regulation of receptor-mediated endocytosis 62
                    positive regulation by symbiont of host receptor-mediated endocytosis 0
                    positive regulation of clathrin-dependent endocytosis 5
                    positive regulation of receptor internalization + 33
                    positive regulation of receptor-mediated endocytosis involved in cholesterol transport 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.