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ONTOLOGY REPORT - ANNOTATIONS


Term:response to pain
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Accession:GO:0048265 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
Synonyms:exact_synonym: physiological response to pain
 alt_id: GO:0048267


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response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1A calcium voltage-gated channel subunit alpha1 A ISO (MGI:MGI:2153687|PMID:11718712) MGI PMID:11718712 MGI:MGI:2153687 NCBI chr19:12,769,586...13,189,022
Ensembl chr19:13,507,102...13,804,729
JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B ISO (MGI:MGI:3607758|PMID:12074836) MGI PMID:12074836 MGI:MGI:3607758 NCBI chr 9:108,989,621...109,256,841 JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E ISO (MGI:MGI:3607758|PMID:12074836) MGI PMID:12074836 MGI:MGI:3607758 NCBI chr 1:156,796,855...157,296,987
Ensembl chr 1:160,628,089...160,949,270
JBrowse link
G CALCA calcitonin related polypeptide alpha ISO (MGI:MGI:1335275|PMID:10208559), (MGI:MGI:1933070|PMID:11276224) MGI PMID:10208559, PMID:11276224 MGI:MGI:1335275, MGI:MGI:1933070 NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267
JBrowse link
G COMT catechol-O-methyltransferase ISO RGD PMID:17084978 RGD:2289747 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387
JBrowse link
G CRH corticotropin releasing hormone ISO RGD PMID:21463663 RGD:5490545 NCBI chr 8:62,714,721...62,716,979
Ensembl chr 8:64,383,419...64,384,009
JBrowse link
G DBH dopamine beta-hydroxylase ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chr 9:104,761,504...104,784,445
Ensembl chr 9:133,371,821...133,393,697
JBrowse link
G EDNRB endothelin receptor type B ISO RGD PMID:12847519 RGD:1581889 NCBI chr13:59,112,349...59,136,615
Ensembl chr13:78,153,020...78,177,286
JBrowse link
G GCH1 GTP cyclohydrolase 1 ISO PMID:17057711 UniProt PMID:17057711 RGD:8554553 NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393
JBrowse link
G GJA4 gap junction protein alpha 4 ISO RGD PMID:11978404 RGD:728686 NCBI chr 1:34,059,901...34,063,181 JBrowse link
G KCNIP3 potassium voltage-gated channel interacting protein 3 ISO (MGI:MGI:2158115|PMID:11792319) MGI PMID:11792319 MGI:MGI:2158115 NCBI chr2A:104,018,539...104,111,126
Ensembl chr2A:96,200,412...96,291,374
JBrowse link
G NMUR2 neuromedin U receptor 2 ISO (MGI:MGI:3697042|PMID:17030627) MGI PMID:17030627 MGI:MGI:3697042 NCBI chr 5:147,811,260...147,825,659
Ensembl chr 5:153,811,055...153,827,176
JBrowse link
G PRKCG protein kinase C gamma ISO (MGI:MGI:1097759|PMID:9323205) UniProtKB PMID:9323205 MGI:MGI:1097759 NCBI chr19:50,823,372...50,849,003
Ensembl chr19:59,672,097...59,695,977
JBrowse link
G RELN reelin ISO (MGI:MGI:3625412|PMID:16580148) MGI PMID:16580148 MGI:MGI:3625412 NCBI chr 7:95,464,285...95,984,813
Ensembl chr 7:108,208,344...108,728,037
JBrowse link
G RET ret proto-oncogene ISO (MGI:MGI:4441221|PMID:20237269) UniProtKB PMID:20237269 MGI:MGI:4441221 NCBI chr10:40,050,396...40,103,629
Ensembl chr10:43,249,468...43,284,331
JBrowse link
G SLC6A2 solute carrier family 6 member 2 ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chr16:35,885,756...35,935,638
Ensembl chr16:54,990,773...55,040,504
JBrowse link
G TAC1 tachykinin precursor 1 ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chr 7:89,675,834...89,684,391
Ensembl chr 7:103,257,501...103,266,389
JBrowse link
G TACR1 tachykinin receptor 1 ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 ISO (MGI:MGI:3790902|PMID:18272293)
(MGI:MGI:3623714|PMID:16630838), (MGI:MGI:3794274|PMID:18297068)
MGI PMID:16630838, PMID:18272293, PMID:18297068 MGI:MGI:3623714, MGI:MGI:3790902, MGI:MGI:3794274 NCBI chr 8:68,551,685...68,605,336
Ensembl chr 8:70,210,352...70,262,627
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO (MGI:MGI:3790902|PMID:18272293)
(MGI:MGI:3794274|PMID:18297068)
MGI PMID:18272293, PMID:18297068 MGI:MGI:3790902, MGI:MGI:3794274 NCBI chr17:3,612,781...3,658,608
Ensembl chr17:3,609,952...3,637,579
JBrowse link
G TSPO translocator protein ISO RGD PMID:19555675 RGD:2317138 NCBI chr22:24,034,918...24,046,370
Ensembl chr22:42,233,619...42,244,930
JBrowse link
G UCN urocortin ISO RGD PMID:21463663 RGD:5490545 NCBI chr2A:27,309,458...27,311,268
Ensembl chr2A:27,397,295...27,397,669
JBrowse link
behavioral response to formalin induced pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KALRN kalirin RhoGEF kinase ISO (MGI:MGI:5645427|PMID:25865668) MGI PMID:25865668 MGI:MGI:5645427 NCBI chr 3:121,138,136...121,828,723 JBrowse link
G P2RX3 purinergic receptor P2X 3 ISO RGD PMID:24120766 RGD:10043614 NCBI chr11:52,579,190...52,614,329
Ensembl chr 3:160,070,875...160,106,120
JBrowse link
behavioral response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1A calcium voltage-gated channel subunit alpha1 A ISO (MGI:MGI:3664669|PMID:16890369) MGI PMID:16890369 MGI:MGI:3664669 NCBI chr19:12,769,586...13,189,022
Ensembl chr19:13,507,102...13,804,729
JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E ISO (MGI:MGI:1858676|PMID:10801976) MGI PMID:10801976 MGI:MGI:1858676 NCBI chr 1:156,796,855...157,296,987
Ensembl chr 1:160,628,089...160,949,270
JBrowse link
G CAPN2 calpain 2 ISO RGD PMID:25150005 RGD:13792585 NCBI chr 1:199,335,582...199,399,267
Ensembl chr 1:204,335,573...204,409,150
JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO RGD PMID:17550594 RGD:1626231 NCBI chr17:11,261,435...11,313,630 JBrowse link
G GIT2 GIT ArfGAP 2 ISO (MGI:MGI:5506968|PMID:23870131) MGI PMID:23870131 MGI:MGI:5506968 NCBI chr12:107,505,791...107,572,641
Ensembl chr12:110,901,303...110,967,489
JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 ISO (MGI:MGI:3577154|PMID:15673679) MGI PMID:15673679 MGI:MGI:3577154 NCBI chr21:15,976,931...16,357,578
Ensembl chr21:29,364,269...29,743,379
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B ISO (MGI:MGI:3610653|PMID:11711849) MGI PMID:11711849 MGI:MGI:3610653 NCBI chr12:13,543,104...13,987,437
Ensembl chr12:13,969,387...14,388,799
JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 ISO RGD PMID:16098671 RGD:6480679 NCBI chr10:87,480,970...87,598,212
Ensembl chr10:91,009,941...91,125,158
JBrowse link
G KCNIP3 potassium voltage-gated channel interacting protein 3 ISO (MGI:MGI:2677561|PMID:14534243) MGI PMID:14534243 MGI:MGI:2677561 NCBI chr2A:104,018,539...104,111,126
Ensembl chr2A:96,200,412...96,291,374
JBrowse link
G LPAR5 lysophosphatidic acid receptor 5 ISO (MGI:MGI:5429492|PMID:22461625) MGI PMID:22461625 MGI:MGI:5429492 NCBI chr12:6,749,957...6,767,221
Ensembl chr12:6,668,991...6,670,109
JBrowse link
G OSM oncostatin M ISO (MGI:MGI:3574134|PMID:14985435) MGI PMID:14985435 MGI:MGI:3574134 NCBI chr22:11,298,965...11,303,009
Ensembl chr22:29,101,085...29,105,081
JBrowse link
G P2RX2 purinergic receptor P2X 2 ISO (MGI:MGI:3656422|PMID:15961431) MGI PMID:15961431 MGI:MGI:3656422 NCBI chr12:129,969,793...129,974,399 JBrowse link
G P2RX3 purinergic receptor P2X 3 ISO (MGI:MGI:3656422|PMID:15961431)
(MGI:MGI:1926736|PMID:11069182)
(MGI:MGI:1926735|PMID:11069181)
MGI PMID:11069181, PMID:11069182, PMID:15961431 MGI:MGI:1926735, MGI:MGI:1926736, MGI:MGI:3656422 NCBI chr11:52,579,190...52,614,329
Ensembl chr 3:160,070,875...160,106,120
JBrowse link
G P2RX4 purinergic receptor P2X 4 ISO PMID:12917686 ARUK-UCL PMID:12917686 RGD:13673840 NCBI chr12:118,807,961...118,832,267
Ensembl chr12:122,178,672...122,202,959
JBrowse link
G PIRT phosphoinositide interacting regulator of transient receptor potential channels ISO (MGI:MGI:3834285|PMID:18455988) MGI PMID:18455988 MGI:MGI:3834285 NCBI chr17:40,815,724...40,831,539 JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 ISO (MGI:MGI:3052623|PMID:15314237) MGI PMID:15314237 MGI:MGI:3052623 NCBI chr2B:53,468,290...53,643,747
Ensembl chr2B:170,944,974...171,054,013
JBrowse link
G TACR1 tachykinin receptor 1 ISO RGD PMID:18407414 RGD:2304276 NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018
JBrowse link
G THBS1 thrombospondin 1 ISO (MGI:MGI:5516179|PMID:22745497) UniProtKB PMID:22745497 MGI:MGI:5516179 NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170
JBrowse link
G THBS4 thrombospondin 4 ISO PMID:22745497
(MGI:MGI:5516179|PMID:22745497)
UniProt
UniProtKB
PMID:22745497 MGI:MGI:5516179, RGD:8553360 NCBI chr 5:35,232,459...35,324,613
Ensembl chr 5:35,505,375...35,553,040
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO (MGI:MGI:3834285|PMID:18455988)
(MGI:MGI:3763480|PMID:17767493), (MGI:MGI:3778264|PMID:18272658)
MGI PMID:17767493, PMID:18272658, PMID:18455988 MGI:MGI:3763480, MGI:MGI:3778264, MGI:MGI:3834285 NCBI chr17:3,612,781...3,658,608
Ensembl chr17:3,609,952...3,637,579
JBrowse link
G TSPO translocator protein ISO RGD PMID:19555675 RGD:2317138 NCBI chr22:24,034,918...24,046,370
Ensembl chr22:42,233,619...42,244,930
JBrowse link
G VWA1 von Willebrand factor A domain containing 1 ISO (MGI:MGI:3849094|PMID:19279005) MGI PMID:19279005 MGI:MGI:3849094 NCBI chr 1:192,970...198,099 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12561
    multicellular organismal process 6470
      multicellular organismal response to stress 104
        response to pain 39
          behavioral response to pain + 23
Path 2
Term Annotations click to browse term
  biological_process 12561
    response to stimulus 6736
      response to stress 3232
        multicellular organismal response to stress 104
          response to pain 39
            behavioral response to pain + 23
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.