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ONTOLOGY REPORT - ANNOTATIONS


Term:response to pain
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Accession:GO:0048265 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
Synonyms:exact_synonym: physiological response to pain
 alt_id: GO:0048267


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response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO (MGI:MGI:2153687|PMID:11718712) MGI PMID:11718712 MGI:MGI:2153687 NCBI chrNW_004955415:32,182,536...32,457,511
Ensembl chrNW_004955415:32,183,442...32,400,595
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B ISO (MGI:MGI:3607758|PMID:12074836) MGI PMID:12074836 MGI:MGI:3607758 NCBI chrNW_004955513:5,654,915...5,823,094
Ensembl chrNW_004955513:5,654,238...5,824,386
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO (MGI:MGI:3607758|PMID:12074836) MGI PMID:12074836 MGI:MGI:3607758 NCBI chrNW_004955406:20,356,564...20,824,679
Ensembl chrNW_004955406:20,510,954...20,816,678
JBrowse link
G Comt catechol-O-methyltransferase ISO RGD PMID:17084978 RGD:2289747 NCBI chrNW_004955442:18,130,282...18,152,153
Ensembl chrNW_004955442:18,130,987...18,137,412
JBrowse link
G Crh corticotropin releasing hormone ISO RGD PMID:21463663 RGD:5490545 NCBI chrNW_004955444:12,989,210...12,991,300 JBrowse link
G Dbh dopamine beta-hydroxylase ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chrNW_004955513:2,918,085...2,932,481
Ensembl chrNW_004955513:2,918,286...2,932,247
JBrowse link
G Ednrb endothelin receptor type B ISO RGD PMID:12847519 RGD:1581889 NCBI chrNW_004955404:29,394,253...29,425,358
Ensembl chrNW_004955404:29,394,164...29,425,358
JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO PMID:17057711 UniProt PMID:17057711 RGD:8554553 NCBI chrNW_004955409:8,624,225...8,670,436
Ensembl chrNW_004955409:8,624,468...8,668,614
JBrowse link
G Gja4 gap junction protein alpha 4 ISO RGD PMID:11978404 RGD:728686 NCBI chrNW_004955452:12,902,764...12,905,337
Ensembl chrNW_004955452:12,902,773...12,905,337
JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 ISO (MGI:MGI:2158115|PMID:11792319) MGI PMID:11792319 MGI:MGI:2158115 NCBI chrNW_004955470:3,545,434...3,613,288
Ensembl chrNW_004955470:3,545,172...3,613,296
JBrowse link
G Nmur2 neuromedin U receptor 2 ISO (MGI:MGI:3697042|PMID:17030627) MGI PMID:17030627 MGI:MGI:3697042 NCBI chrNW_004955408:6,862,243...6,872,805 JBrowse link
G Prkcg protein kinase C gamma ISO (MGI:MGI:1097759|PMID:9323205) UniProtKB PMID:9323205 MGI:MGI:1097759 NCBI chrNW_004955604:262,182...279,259
Ensembl chrNW_004955604:262,071...279,259
JBrowse link
G Reln reelin ISO (MGI:MGI:3625412|PMID:16580148) MGI PMID:16580148 MGI:MGI:3625412 NCBI chrNW_004955410:8,424,439...8,863,966
Ensembl chrNW_004955410:8,424,394...8,863,969
JBrowse link
G Ret ret proto-oncogene ISO (MGI:MGI:4441221|PMID:20237269) UniProtKB PMID:20237269 MGI:MGI:4441221 NCBI chrNW_004955546:1,221,995...1,252,147
Ensembl chrNW_004955546:1,221,995...1,253,946
JBrowse link
G Slc6a2 solute carrier family 6 member 2 ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chrNW_004955433:13,170,986...13,216,270
Ensembl chrNW_004955433:13,170,699...13,216,330
JBrowse link
G Tac1 tachykinin precursor 1 ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chrNW_004955432:13,991,647...13,999,665
Ensembl chrNW_004955432:13,991,414...13,999,728
JBrowse link
G Tacr1 tachykinin receptor 1 ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chrNW_004955424:10,614,340...10,761,872
Ensembl chrNW_004955424:10,614,340...10,761,872
JBrowse link
G Trpa1 transient receptor potential cation channel subfamily A member 1 ISO (MGI:MGI:3790902|PMID:18272293)
(MGI:MGI:3623714|PMID:16630838), (MGI:MGI:3794274|PMID:18297068)
MGI PMID:16630838, PMID:18272293, PMID:18297068 MGI:MGI:3623714, MGI:MGI:3790902, MGI:MGI:3794274 NCBI chrNW_004955444:7,876,284...7,922,010
Ensembl chrNW_004955444:7,876,429...7,921,372
JBrowse link
G Trpv1 transient receptor potential cation channel subfamily V member 1 ISO (MGI:MGI:3790902|PMID:18272293)
(MGI:MGI:3794274|PMID:18297068)
MGI PMID:18272293, PMID:18297068 MGI:MGI:3790902, MGI:MGI:3794274 NCBI chrNW_004955467:13,221,391...13,239,089
Ensembl chrNW_004955467:13,221,391...13,239,089
JBrowse link
G Tspo translocator protein ISO RGD PMID:19555675 RGD:2317138 NCBI chrNW_004955413:28,309,105...28,315,075
Ensembl chrNW_004955413:28,308,658...28,315,075
JBrowse link
G Ucn urocortin ISO RGD PMID:21463663 RGD:5490545 NCBI chrNW_004955469:9,277,637...9,278,641
Ensembl chrNW_004955469:9,277,637...9,278,641
JBrowse link
behavioral response to formalin induced pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kalrn kalirin RhoGEF kinase ISO (MGI:MGI:5645427|PMID:25865668) MGI PMID:25865668 MGI:MGI:5645427 NCBI chrNW_004955427:23,184,751...23,823,128
Ensembl chrNW_004955427:23,184,739...23,816,811
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO (MGI:MGI:5571523|PMID:24760869) MGI PMID:24760869 MGI:MGI:5571523 NCBI chrNW_004955545:2,929,704...2,947,579
Ensembl chrNW_004955545:2,929,704...2,947,579
JBrowse link
G P2rx3 purinergic receptor P2X 3 ISO RGD PMID:24120766 RGD:10043614 NCBI chrNW_004955511:2,389,717...2,410,968
Ensembl chrNW_004955511:2,389,717...2,411,008
JBrowse link
behavioral response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO (MGI:MGI:3664669|PMID:16890369) MGI PMID:16890369 MGI:MGI:3664669 NCBI chrNW_004955415:32,182,536...32,457,511
Ensembl chrNW_004955415:32,183,442...32,400,595
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO (MGI:MGI:1858676|PMID:10801976) MGI PMID:10801976 MGI:MGI:1858676 NCBI chrNW_004955406:20,356,564...20,824,679
Ensembl chrNW_004955406:20,510,954...20,816,678
JBrowse link
G Capn2 calpain 2 ISO RGD PMID:25150005 RGD:13792585 NCBI chrNW_004955520:1,287,829...1,315,318
Ensembl chrNW_004955520:1,286,356...1,315,328
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:17550594 RGD:1626231 NCBI chrNW_004955478:10,380,185...10,390,838 JBrowse link
G Git2 GIT ArfGAP 2 ISO (MGI:MGI:5506968|PMID:23870131) MGI PMID:23870131 MGI:MGI:5506968 NCBI chrNW_004955455:8,611,218...8,669,527
Ensembl chrNW_004955455:8,613,490...8,670,205
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 ISO (MGI:MGI:3577154|PMID:15673679) MGI PMID:15673679 MGI:MGI:3577154 NCBI chrNW_004955407:28,899,643...29,308,936
Ensembl chrNW_004955407:28,899,899...29,308,470
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO (MGI:MGI:3610653|PMID:11711849) MGI PMID:11711849 MGI:MGI:3610653 NCBI chrNW_004955413:10,358,931...10,780,004
Ensembl chrNW_004955413:10,376,597...10,779,145
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 ISO RGD PMID:16098671 RGD:6480679 NCBI chrNW_004955425:2,321,420...2,420,420
Ensembl chrNW_004955425:2,321,420...2,420,530
JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 ISO (MGI:MGI:2677561|PMID:14534243) MGI PMID:14534243 MGI:MGI:2677561 NCBI chrNW_004955470:3,545,434...3,613,288
Ensembl chrNW_004955470:3,545,172...3,613,296
JBrowse link
G Lpar5 lysophosphatidic acid receptor 5 ISO (MGI:MGI:5429492|PMID:22461625) MGI PMID:22461625 MGI:MGI:5429492 NCBI chrNW_004955413:4,238,312...4,249,869
Ensembl chrNW_004955413:4,238,319...4,249,869
JBrowse link
G Osm oncostatin M ISO (MGI:MGI:3574134|PMID:14985435) MGI PMID:14985435 MGI:MGI:3574134 NCBI chrNW_004955455:4,510,711...4,515,282
Ensembl chrNW_004955455:4,511,769...4,514,633
JBrowse link
G P2rx2 purinergic receptor P2X 2 ISO (MGI:MGI:3656422|PMID:15961431) MGI PMID:15961431 MGI:MGI:3656422 NCBI chrNW_004955482:418,101...422,058
Ensembl chrNW_004955482:419,213...421,583
JBrowse link
G P2rx3 purinergic receptor P2X 3 ISO (MGI:MGI:1926736|PMID:11069182)
(MGI:MGI:3656422|PMID:15961431)
(MGI:MGI:1926735|PMID:11069181)
MGI PMID:11069181, PMID:11069182, PMID:15961431 MGI:MGI:1926735, MGI:MGI:1926736, MGI:MGI:3656422 NCBI chrNW_004955511:2,389,717...2,410,968
Ensembl chrNW_004955511:2,389,717...2,411,008
JBrowse link
G P2rx4 purinergic receptor P2X 4 ISO PMID:12917686 ARUK-UCL PMID:12917686 RGD:13673840 NCBI chrNW_004955482:7,031,874...7,039,026
Ensembl chrNW_004955482:7,031,874...7,039,220
JBrowse link
G Pirt phosphoinositide interacting regulator of transient receptor potential channels ISO (MGI:MGI:3834285|PMID:18455988) MGI PMID:18455988 MGI:MGI:3834285 NCBI chrNW_004955467:6,375,992...6,391,770
Ensembl chrNW_004955467:6,375,992...6,391,764
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO (MGI:MGI:3052623|PMID:15314237) MGI PMID:15314237 MGI:MGI:3052623 NCBI chrNW_004955449:7,858,156...8,017,569
Ensembl chrNW_004955449:7,923,801...8,017,569
JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:18407414 RGD:2304276 NCBI chrNW_004955424:10,614,340...10,761,872
Ensembl chrNW_004955424:10,614,340...10,761,872
JBrowse link
G Thbs1 thrombospondin 1 ISO (MGI:MGI:5516179|PMID:22745497) UniProtKB PMID:22745497 MGI:MGI:5516179 NCBI chrNW_004955416:6,490,034...6,506,419
Ensembl chrNW_004955416:6,489,451...6,506,419
JBrowse link
G Thbs4 thrombospondin 4 ISO PMID:22745497
(MGI:MGI:5516179|PMID:22745497)
UniProt
UniProtKB
PMID:22745497 MGI:MGI:5516179, RGD:8553360 NCBI chrNW_004955425:21,072,873...21,117,061
Ensembl chrNW_004955425:21,069,855...21,117,061
JBrowse link
G Trpv1 transient receptor potential cation channel subfamily V member 1 ISO (MGI:MGI:3834285|PMID:18455988)
(MGI:MGI:3763480|PMID:17767493), (MGI:MGI:3778264|PMID:18272658)
MGI PMID:17767493, PMID:18272658, PMID:18455988 MGI:MGI:3763480, MGI:MGI:3778264, MGI:MGI:3834285 NCBI chrNW_004955467:13,221,391...13,239,089
Ensembl chrNW_004955467:13,221,391...13,239,089
JBrowse link
G Tspo translocator protein ISO RGD PMID:19555675 RGD:2317138 NCBI chrNW_004955413:28,309,105...28,315,075
Ensembl chrNW_004955413:28,308,658...28,315,075
JBrowse link
G Vwa1 von Willebrand factor A domain containing 1 ISO (MGI:MGI:3849094|PMID:19279005) MGI PMID:19279005 MGI:MGI:3849094 NCBI chrNW_004955486:9,365,920...9,369,117
Ensembl chrNW_004955486:9,366,796...9,369,115
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11889
    multicellular organismal process 6168
      multicellular organismal response to stress 104
        response to pain 39
          behavioral response to pain + 24
Path 2
Term Annotations click to browse term
  biological_process 11889
    response to stimulus 6365
      response to stress 3035
        multicellular organismal response to stress 104
          response to pain 39
            behavioral response to pain + 24
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.