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ONTOLOGY REPORT - ANNOTATIONS


Term:response to pain
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Accession:GO:0048265 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
Synonyms:exact_synonym: physiological response to pain
 alt_id: GO:0048267


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response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1A calcium voltage-gated channel subunit alpha1 A ISO (MGI:MGI:2153687|PMID:11718712) MGI PMID:11718712 MGI:MGI:2153687 NCBI chr19:13,206,442...13,506,479
Ensembl chr19:13,206,442...13,633,025
JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B IEA Ensembl GO_REF:0000107 NCBI chr 9:137,877,782...138,124,619
Ensembl chr 9:137,877,782...138,124,624
JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E ISO (MGI:MGI:3607758|PMID:12074836) MGI PMID:12074836 MGI:MGI:3607758 NCBI chr 1:181,317,712...181,808,084
Ensembl chr 1:181,317,690...181,808,084
JBrowse link
G CALCA calcitonin related polypeptide alpha IEA Ensembl GO_REF:0000107 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G COMT catechol-O-methyltransferase IEA Ensembl GO_REF:0000107 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G CRH corticotropin releasing hormone IEA Ensembl GO_REF:0000107 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G DBH dopamine beta-hydroxylase IEA Ensembl GO_REF:0000107 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329
JBrowse link
G EDNRB endothelin receptor type B IEA Ensembl GO_REF:0000107 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529
JBrowse link
G GCH1 GTP cyclohydrolase 1 ISS UniProtKB GO_REF:0000024 NCBI chr14:54,842,016...54,902,826
Ensembl chr14:54,842,008...54,902,826
JBrowse link
G GJA4 gap junction protein alpha 4 IEA Ensembl GO_REF:0000107 NCBI chr 1:34,792,958...34,795,747
Ensembl chr 1:34,792,999...34,795,747
JBrowse link
G KCNIP3 potassium voltage-gated channel interacting protein 3 ISO (MGI:MGI:2158115|PMID:11792319) MGI PMID:11792319 MGI:MGI:2158115 NCBI chr 2:95,297,325...95,386,077
Ensembl chr 2:95,297,327...95,386,077
JBrowse link
G NMUR2 neuromedin U receptor 2 IEA Ensembl GO_REF:0000107 NCBI chr 5:152,391,546...152,405,279
Ensembl chr 5:152,391,532...152,433,368
Ensembl chr 5:152,391,532...152,433,368
JBrowse link
G PRKCG protein kinase C gamma ISS UniProtKB GO_REF:0000024 NCBI chr19:53,882,197...53,907,652
Ensembl chr19:53,879,190...53,907,652
JBrowse link
G RELN reelin ISS UniProtKB GO_REF:0000024 NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,784...103,989,658
JBrowse link
G RET ret proto-oncogene ISS UniProtKB GO_REF:0000024 NCBI chr10:43,077,069...43,130,351
Ensembl chr10:43,077,064...43,130,351
JBrowse link
G SLC6A2 solute carrier family 6 member 2 IEA Ensembl GO_REF:0000107 NCBI chr16:55,655,928...55,706,192
Ensembl chr16:55,655,604...55,706,192
JBrowse link
G TAC1 tachykinin precursor 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472
JBrowse link
G TACR1 tachykinin receptor 1 ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chr 2:75,046,463...75,199,520
Ensembl chr 2:75,046,463...75,199,520
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO (MGI:MGI:3790902|PMID:18272293)
(MGI:MGI:3794274|PMID:18297068)
MGI PMID:18272293, PMID:18297068 MGI:MGI:3790902, MGI:MGI:3794274 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G TSPO translocator protein ISO RGD PMID:19555675 RGD:2317138 NCBI chr22:43,151,559...43,163,242
Ensembl chr22:43,151,547...43,163,242
JBrowse link
G UCN urocortin IEA Ensembl GO_REF:0000107 NCBI chr 2:27,307,400...27,308,445
Ensembl chr 2:27,307,400...27,308,445
JBrowse link
behavioral response to formalin induced pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KALRN kalirin RhoGEF kinase ISO (MGI:MGI:5645427|PMID:25865668) MGI PMID:25865668 MGI:MGI:5645427 NCBI chr 3:124,033,341...124,726,325
Ensembl chr 3:124,080,023...124,726,325
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,640...156,881,850
JBrowse link
G P2RX3 purinergic receptor P2X 3 IEA Ensembl GO_REF:0000107 NCBI chr11:57,335,943...57,372,399
Ensembl chr11:57,338,352...57,372,396
JBrowse link
behavioral response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1A calcium voltage-gated channel subunit alpha1 A IEA Ensembl GO_REF:0000107 NCBI chr19:13,206,442...13,506,479
Ensembl chr19:13,206,442...13,633,025
JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E ISO (MGI:MGI:1858676|PMID:10801976) MGI PMID:10801976 MGI:MGI:1858676 NCBI chr 1:181,317,712...181,808,084
Ensembl chr 1:181,317,690...181,808,084
JBrowse link
G CAPN2 calpain 2 IEA Ensembl GO_REF:0000107 NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018
JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO RGD PMID:17550594 RGD:1626231 NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,280...45,835,828
JBrowse link
G GIT2 GIT ArfGAP 2 ISO (MGI:MGI:5506968|PMID:23870131) MGI PMID:23870131 MGI:MGI:5506968 NCBI chr12:109,929,792...109,996,368
Ensembl chr12:109,929,802...109,996,389
JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 ISO (MGI:MGI:3577154|PMID:15673679) MGI PMID:15673679 MGI:MGI:3577154 NCBI chr21:29,536,933...29,939,996
Ensembl chr21:29,536,933...29,940,033
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B ISO (MGI:MGI:3610653|PMID:11711849) MGI PMID:11711849 MGI:MGI:3610653 NCBI chr12:13,537,337...13,982,012
Ensembl chr12:13,437,942...13,982,002
Ensembl chr12:13,437,942...13,982,002
JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 ISO RGD PMID:16098671 RGD:6480679 NCBI chr10:90,738,693...90,858,039
Ensembl chr10:90,740,823...90,858,039
JBrowse link
G KCNIP3 potassium voltage-gated channel interacting protein 3 ISO (MGI:MGI:2677561|PMID:14534243) MGI PMID:14534243 MGI:MGI:2677561 NCBI chr 2:95,297,325...95,386,077
Ensembl chr 2:95,297,327...95,386,077
JBrowse link
G LPAR5 lysophosphatidic acid receptor 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:6,618,835...6,635,959
Ensembl chr12:6,618,835...6,635,960
JBrowse link
G OSM oncostatin M ISO (MGI:MGI:3574134|PMID:14985435) MGI PMID:14985435 MGI:MGI:3574134 NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851
JBrowse link
G P2RX2 purinergic receptor P2X 2 IEA Ensembl GO_REF:0000107 NCBI chr12:132,618,776...132,623,736
Ensembl chr12:132,618,776...132,622,388
JBrowse link
G P2RX3 purinergic receptor P2X 3 ISO (MGI:MGI:1926736|PMID:11069182)
(MGI:MGI:3656422|PMID:15961431)
(MGI:MGI:1926735|PMID:11069181)
MGI PMID:11069181, PMID:11069182, PMID:15961431 MGI:MGI:1926735, MGI:MGI:1926736, MGI:MGI:3656422 NCBI chr11:57,335,943...57,372,399
Ensembl chr11:57,338,352...57,372,396
JBrowse link
G P2RX4 purinergic receptor P2X 4 ISS ARUK-UCL GO_REF:0000024 NCBI chr12:121,210,096...121,234,106
Ensembl chr12:121,209,861...121,234,106
Ensembl chr12:121,209,861...121,234,106
JBrowse link
G PIRT phosphoinositide interacting regulator of transient receptor potential channels IEA Ensembl GO_REF:0000107 NCBI chr17:10,822,470...10,838,087
Ensembl chr17:10,822,470...10,838,087
JBrowse link
G RUNX1 RUNX family transcription factor 1 ISO (MGI:MGI:3619829|PMID:16446141) MGI PMID:16446141 MGI:MGI:3619829 NCBI chr21:34,787,801...35,049,334
Ensembl chr21:34,787,801...36,004,667
JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr 2:166,195,185...166,375,987
Ensembl chr 2:166,195,185...166,376,001
JBrowse link
G TACR1 tachykinin receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:75,046,463...75,199,520
Ensembl chr 2:75,046,463...75,199,520
JBrowse link
G THBS1 thrombospondin 1 ISS UniProtKB GO_REF:0000024 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
G THBS4 thrombospondin 4 ISS UniProtKB GO_REF:0000024 NCBI chr 5:79,991,332...80,083,753
Ensembl chr 5:79,991,311...80,083,287
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 IEA Ensembl GO_REF:0000107 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G TSPO translocator protein IEA Ensembl GO_REF:0000107 NCBI chr22:43,151,559...43,163,242
Ensembl chr22:43,151,547...43,163,242
JBrowse link
G VWA1 von Willebrand factor A domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:1,435,690...1,442,882
Ensembl chr 1:1,434,861...1,442,882
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    multicellular organismal process 8775
      multicellular organismal response to stress 107
        response to pain 41
          behavioral response to pain + 25
Path 2
Term Annotations click to browse term
  biological_process 18670
    response to stimulus 10152
      response to stress 4579
        multicellular organismal response to stress 107
          response to pain 41
            behavioral response to pain + 25
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.