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ONTOLOGY REPORT - ANNOTATIONS


Term:response to pain
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Accession:GO:0048265 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
Synonyms:exact_synonym: physiological response to pain
 alt_id: GO:0048267


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response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit IMP (MGI:MGI:2153687|PMID:11718712) MGI PMID:11718712 MGI:MGI:2153687 NCBI chr 8:84,338,631...84,640,251
Ensembl chr 8:84,338,639...84,640,246
JBrowse link
G Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit IMP (MGI:MGI:3607758|PMID:12074836) MGI PMID:12074836 MGI:MGI:3607758 NCBI chr 2:24,603,860...24,763,200
Ensembl chr 2:24,603,887...24,763,152
JBrowse link
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit IMP (MGI:MGI:3607758|PMID:12074836) MGI PMID:12074836 MGI:MGI:3607758 NCBI chr 1:154,390,806...154,884,785
Ensembl chr 1:154,390,731...154,884,501
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha IMP (MGI:MGI:1335275|PMID:10208559), (MGI:MGI:1933070|PMID:11276224) MGI PMID:10208559, PMID:11276224 MGI:MGI:1335275, MGI:MGI:1933070 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Comt catechol-O-methyltransferase ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Crh corticotropin releasing hormone ISO RGD PMID:21463663 RGD:5490545 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Dbh dopamine beta hydroxylase IMP (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chr 2:27,165,507...27,183,204
Ensembl chr 2:27,165,233...27,183,200
JBrowse link
G Ednrb endothelin receptor type B ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr14:103,814,615...103,844,508
Ensembl chr14:103,814,625...103,844,402
JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr14:47,153,895...47,189,413
Ensembl chr14:47,153,895...47,189,413
JBrowse link
G Gja4 gap junction protein, alpha 4 ISO RGD PMID:11978404 RGD:728686 NCBI chr 4:127,311,420...127,314,039
Ensembl chr 4:127,311,421...127,314,039
JBrowse link
G Kcnip3 Kv channel interacting protein 3, calsenilin IMP (MGI:MGI:2158115|PMID:11792319) MGI PMID:11792319 MGI:MGI:2158115 NCBI chr 2:127,456,498...127,522,094
Ensembl chr 2:127,456,498...127,522,094
JBrowse link
G Nmur2 neuromedin U receptor 2 IMP (MGI:MGI:3697042|PMID:17030627) MGI PMID:17030627 MGI:MGI:3697042 NCBI chr11:56,024,990...56,040,987
Ensembl chr11:56,024,987...56,041,010
JBrowse link
G Prkcg protein kinase C, gamma IMP (MGI:MGI:1097759|PMID:9323205) UniProtKB PMID:9323205 MGI:MGI:1097759 NCBI chr 7:3,303,532...3,331,099
Ensembl chr 7:3,289,179...3,331,099
JBrowse link
G Reln reelin IMP (MGI:MGI:3625412|PMID:16580148) MGI PMID:16580148 MGI:MGI:3625412 NCBI chr 5:21,884,454...22,344,705
Ensembl chr 5:21,884,454...22,344,702
JBrowse link
G Ret ret proto-oncogene IMP (MGI:MGI:4441221|PMID:20237269) UniProtKB PMID:20237269 MGI:MGI:4441221 NCBI chr 6:118,151,748...118,197,744
Ensembl chr 6:118,151,745...118,197,718
JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 IMP (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chr 8:92,960,470...93,001,667
Ensembl chr 8:92,960,079...93,001,667
JBrowse link
G Tac1 tachykinin 1 IMP (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Tacr1 tachykinin receptor 1 IMP (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chr 6:82,402,003...82,560,104
Ensembl chr 6:82,402,334...82,560,104
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IDA
IMP
(MGI:MGI:3790902|PMID:18272293)
(MGI:MGI:3623714|PMID:16630838), (MGI:MGI:3794274|PMID:18297068)
MGI PMID:16630838, PMID:18272293, PMID:18297068 MGI:MGI:3623714, MGI:MGI:3790902, MGI:MGI:3794274 NCBI chr 1:14,872,644...14,918,862
Ensembl chr 1:14,872,648...14,918,862
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IDA
IMP
(MGI:MGI:3790902|PMID:18272293)
(MGI:MGI:3794274|PMID:18297068)
MGI PMID:18272293, PMID:18297068 MGI:MGI:3790902, MGI:MGI:3794274 NCBI chr11:73,234,149...73,261,322
Ensembl chr11:73,234,292...73,261,242
JBrowse link
G Tspo translocator protein ISO RGD PMID:19555675 RGD:2317138 NCBI chr15:83,563,573...83,574,203
Ensembl chr15:83,563,592...83,574,203
JBrowse link
G Ucn urocortin ISO RGD PMID:21463663 RGD:5490545 NCBI chr 5:31,137,989...31,138,895
Ensembl chr 5:31,138,063...31,138,829
JBrowse link
behavioral response to formalin induced pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kalrn kalirin, RhoGEF kinase IMP (MGI:MGI:5645427|PMID:25865668) MGI PMID:25865668 MGI:MGI:5645427 NCBI chr16:33,969,073...34,573,277
Ensembl chr16:33,969,073...34,573,532
JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 IMP (MGI:MGI:5571523|PMID:24760869) MGI PMID:24760869 MGI:MGI:5571523 NCBI chr 3:87,778,244...87,795,242
Ensembl chr 3:87,778,244...87,795,162
JBrowse link
G P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 2:84,996,549...85,037,108
Ensembl chr 2:84,998,583...85,037,462
JBrowse link
behavioral response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit IMP (MGI:MGI:3664669|PMID:16890369) MGI PMID:16890369 MGI:MGI:3664669 NCBI chr 8:84,338,631...84,640,251
Ensembl chr 8:84,338,639...84,640,246
JBrowse link
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit IMP (MGI:MGI:1858676|PMID:10801976) MGI PMID:10801976 MGI:MGI:1858676 NCBI chr 1:154,390,806...154,884,785
Ensembl chr 1:154,390,731...154,884,501
JBrowse link
G Capn2 calpain 2 ISO MGI GO_REF:0000096, MGI:MGI:4417868 NCBI chr 1:182,467,253...182,517,610
Ensembl chr 1:182,467,260...182,517,608
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr11:104,130,463...104,175,523
Ensembl chr11:104,132,855...104,175,523
JBrowse link
G Git2 GIT ArfGAP 2 IMP (MGI:MGI:5506968|PMID:23870131) MGI PMID:23870131 MGI:MGI:5506968 NCBI chr 5:114,727,408...114,774,588
Ensembl chr 5:114,727,407...114,775,517
JBrowse link
G Grik1 glutamate receptor, ionotropic, kainate 1 IMP (MGI:MGI:3577154|PMID:15673679) MGI PMID:15673679 MGI:MGI:3577154 NCBI chr16:87,895,901...88,290,863
Ensembl chr16:87,895,900...88,290,265
JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) IMP (MGI:MGI:3610653|PMID:11711849) MGI PMID:11711849 MGI:MGI:3610653 NCBI chr 6:135,713,221...136,173,615
Ensembl chr 6:135,713,233...136,173,511
JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr19:35,958,415...36,058,133
Ensembl chr19:35,958,734...36,057,507
JBrowse link
G Kcnip3 Kv channel interacting protein 3, calsenilin IMP (MGI:MGI:2677561|PMID:14534243) MGI PMID:14534243 MGI:MGI:2677561 NCBI chr 2:127,456,498...127,522,094
Ensembl chr 2:127,456,498...127,522,094
JBrowse link
G Lpar5 lysophosphatidic acid receptor 5 IMP
IBA
(MGI:MGI:5429492|PMID:22461625)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:21873635, PMID:22461625 MGI:MGI:5429492, MGI:MGI:6201960 NCBI chr 6:125,067,844...125,086,129
Ensembl chr 6:125,067,920...125,082,472
JBrowse link
G Osm oncostatin M IMP (MGI:MGI:3574134|PMID:14985435) MGI PMID:14985435 MGI:MGI:3574134 NCBI chr11:4,236,785...4,241,026
Ensembl chr11:4,236,420...4,241,026
JBrowse link
G P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 IGI
IMP
(MGI:MGI:3656422|PMID:15961431) MGI PMID:15961431 MGI:MGI:3656422 NCBI chr 5:110,339,812...110,343,320
Ensembl chr 5:110,339,812...110,343,212
JBrowse link
G P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 IMP
IGI
(MGI:MGI:1926735|PMID:11069181)
(MGI:MGI:3656422|PMID:15961431)
(MGI:MGI:1926736|PMID:11069182)
MGI PMID:11069181, PMID:11069182, PMID:15961431 MGI:MGI:1926735, MGI:MGI:1926736, MGI:MGI:3656422 NCBI chr 2:84,996,549...85,037,108
Ensembl chr 2:84,998,583...85,037,462
JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 ISO MGI GO_REF:0000096, MGI:MGI:4417868 NCBI chr 5:122,707,518...122,729,739
Ensembl chr 5:122,707,544...122,729,738
JBrowse link
G Pirt phosphoinositide-interacting regulator of transient receptor potential channels IMP (MGI:MGI:3834285|PMID:18455988) MGI PMID:18455988 MGI:MGI:3834285 NCBI chr11:66,911,905...66,929,877
Ensembl chr11:66,911,981...66,929,876
JBrowse link
G Runx1 runt related transcription factor 1 IMP (MGI:MGI:3619829|PMID:16446141) MGI PMID:16446141 MGI:MGI:3619829 NCBI chr16:92,601,466...92,826,074
Ensembl chr16:92,601,466...92,826,149
JBrowse link
G Scn9a sodium channel, voltage-gated, type IX, alpha IMP (MGI:MGI:3052623|PMID:15314237) MGI PMID:15314237 MGI:MGI:3052623 NCBI chr 2:66,480,080...66,635,114
Ensembl chr 2:66,480,080...66,634,962
JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 6:82,402,003...82,560,104
Ensembl chr 6:82,402,334...82,560,104
JBrowse link
G Thbs1 thrombospondin 1 IMP (MGI:MGI:5516179|PMID:22745497) UniProtKB PMID:22745497 MGI:MGI:5516179 NCBI chr 2:118,111,876...118,127,133
Ensembl chr 2:118,111,876...118,127,133
JBrowse link
G Thbs4 thrombospondin 4 IMP
ISO
(MGI:MGI:5516179|PMID:22745497) UniProtKB
RGD
PMID:22745497 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:5516179 NCBI chr13:92,751,586...92,794,818
Ensembl chr13:92,751,590...92,794,818
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IDA
IMP
(MGI:MGI:3834285|PMID:18455988)
(MGI:MGI:3763480|PMID:17767493), (MGI:MGI:3778264|PMID:18272658)
MGI PMID:17767493, PMID:18272658, PMID:18455988 MGI:MGI:3763480, MGI:MGI:3778264, MGI:MGI:3834285 NCBI chr11:73,234,149...73,261,322
Ensembl chr11:73,234,292...73,261,242
JBrowse link
G Tspo translocator protein ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr15:83,563,573...83,574,203
Ensembl chr15:83,563,592...83,574,203
JBrowse link
G Vwa1 von Willebrand factor A domain containing 1 IMP (MGI:MGI:3849094|PMID:19279005) MGI PMID:19279005 MGI:MGI:3849094 NCBI chr 4:155,768,495...155,774,693
Ensembl chr 4:155,768,149...155,774,698
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23386
    multicellular organismal process 8908
      multicellular organismal response to stress 107
        response to pain 41
          behavioral response to pain + 25
Path 2
Term Annotations click to browse term
  biological_process 23386
    response to stimulus 10301
      response to stress 4153
        multicellular organismal response to stress 107
          response to pain 41
            behavioral response to pain + 25
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.