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ONTOLOGY REPORT - ANNOTATIONS


Term:response to pain
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Accession:GO:0048265 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
Synonyms:exact_synonym: physiological response to pain
 alt_id: GO:0048267


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response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1A calcium voltage-gated channel subunit alpha1 A ISO (MGI:MGI:2153687|PMID:11718712) MGI PMID:11718712 MGI:MGI:2153687 NCBI chr 2:65,491,784...65,871,068 JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B IEA Ensembl GO_REF:0000107
G CACNA1E calcium voltage-gated channel subunit alpha1 E ISO (MGI:MGI:3607758|PMID:12074836) MGI PMID:12074836 MGI:MGI:3607758 NCBI chr 9:122,827,386...123,318,372
Ensembl chr 9:122,931,808...123,317,141
JBrowse link
G CALCB calcitonin-related polypeptide beta ISO (MGI:MGI:1335275|PMID:10208559), (MGI:MGI:1933070|PMID:11276224) MGI PMID:10208559, PMID:11276224 MGI:MGI:1335275, MGI:MGI:1933070 NCBI chr 2:44,043,135...44,048,651 JBrowse link
G COMT catechol-O-methyltransferase ISO RGD PMID:17084978 RGD:2289747 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998
JBrowse link
G CRH corticotropin releasing hormone ISO RGD PMID:21463663 RGD:5490545 NCBI chr 4:68,481,696...68,486,122
Ensembl chr 4:68,483,977...68,486,118
JBrowse link
G DBH dopamine beta-hydroxylase IEA Ensembl GO_REF:0000107 NCBI chr 1:273,204,407...273,225,562
Ensembl chr 1:273,204,400...273,225,558
JBrowse link
G EDNRB endothelin receptor type B ISO RGD PMID:12847519 RGD:1581889 NCBI chr11:50,073,300...50,102,879
Ensembl chr11:50,072,554...50,102,884
JBrowse link
G GCH1 GTP cyclohydrolase 1 ISO PMID:17057711 UniProt PMID:17057711 RGD:8554553 NCBI chr 1:184,201,232...184,264,060
Ensembl chr 1:184,202,007...184,257,315
JBrowse link
G GJA4 gap junction protein alpha 4 ISO RGD PMID:11978404 RGD:728686 NCBI chr 6:91,045,430...91,048,161
Ensembl chr 6:91,045,393...91,048,165
JBrowse link
G KCNIP3 potassium voltage-gated channel interacting protein 3 ISO (MGI:MGI:2158115|PMID:11792319) MGI PMID:11792319 MGI:MGI:2158115 NCBI chr 3:45,906,668...46,000,721
Ensembl chr 3:45,906,673...46,000,187
JBrowse link
G NMUR2 neuromedin U receptor 2 IEA Ensembl GO_REF:0000107 NCBI chr16:70,659,732...70,672,346
Ensembl chr16:70,659,521...70,676,316
JBrowse link
G PRKCG protein kinase C gamma IEA Ensembl GO_REF:0000107 NCBI chr 6:56,213,479...56,235,683
Ensembl chr 6:56,213,483...56,234,656
JBrowse link
G RELN reelin IEA Ensembl GO_REF:0000107 NCBI chr 9:103,460,855...103,963,728
Ensembl chr 9:103,460,857...103,963,965
JBrowse link
G RET ret proto-oncogene IEA Ensembl GO_REF:0000107 NCBI chr14:61,305,818...61,361,416
Ensembl chr14:61,305,841...61,361,415
JBrowse link
G SLC6A2 solute carrier family 6 member 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:29,931,650...29,981,636
Ensembl chr 6:29,931,664...29,980,823
JBrowse link
G TAC1 tachykinin precursor 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,535...77,206,526
JBrowse link
G TACR1 tachykinin receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:67,839,367...68,021,733
Ensembl chr 3:67,839,411...68,021,728
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 IEA Ensembl GO_REF:0000107 NCBI chr 4:63,493,374...63,558,486
Ensembl chr 4:63,306,738...63,558,485
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO (MGI:MGI:3790902|PMID:18272293)
(MGI:MGI:3794274|PMID:18297068)
MGI PMID:18272293, PMID:18297068 MGI:MGI:3790902, MGI:MGI:3794274 NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,701,325
JBrowse link
G TSPO translocator protein ISO RGD PMID:19555675 RGD:2317138 NCBI chr 5:5,723,190...5,735,097
Ensembl chr 5:5,723,186...5,735,128
JBrowse link
G UCN urocortin ISO RGD PMID:21463663 RGD:5490545 NCBI chr 3:111,834,082...111,835,932 JBrowse link
behavioral response to formalin induced pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NTRK1 neurotrophic receptor tyrosine kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,237,930
JBrowse link
G P2RX3 purinergic receptor P2X 3 ISO RGD PMID:24120766 RGD:10043614 NCBI chr 2:13,584,913...13,619,652
Ensembl chr 2:13,585,926...13,617,769
JBrowse link
behavioral response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1A calcium voltage-gated channel subunit alpha1 A ISO (MGI:MGI:3664669|PMID:16890369) MGI PMID:16890369 MGI:MGI:3664669 NCBI chr 2:65,491,784...65,871,068 JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E ISO (MGI:MGI:1858676|PMID:10801976) MGI PMID:10801976 MGI:MGI:1858676 NCBI chr 9:122,827,386...123,318,372
Ensembl chr 9:122,931,808...123,317,141
JBrowse link
G CAPN2 calpain 2 ISO RGD PMID:25150005 RGD:13792585 NCBI chr10:19,758,824...19,820,241
Ensembl chr10:19,758,762...19,851,989
JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO RGD PMID:17550594 RGD:1626231 NCBI chr12:17,251,361...17,306,308 JBrowse link
G GIT2 GIT ArfGAP 2 ISO (MGI:MGI:5506968|PMID:23870131) MGI PMID:23870131 MGI:MGI:5506968 NCBI chr14:40,995,986...41,051,896
Ensembl chr14:40,995,727...41,051,895
JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 ISO (MGI:MGI:3577154|PMID:15673679) MGI PMID:15673679 MGI:MGI:3577154 NCBI chr13:192,877,707...193,296,954
Ensembl chr13:192,877,618...193,294,952
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B ISO (MGI:MGI:3610653|PMID:11711849) MGI PMID:11711849 MGI:MGI:3610653 NCBI chr 5:58,477,862...58,948,735
Ensembl chr 5:58,480,526...58,927,583
JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 ISO RGD PMID:16098671 RGD:6480679 NCBI chr14:102,443,312...102,548,894
Ensembl chr14:102,444,566...102,548,931
JBrowse link
G KCNIP3 potassium voltage-gated channel interacting protein 3 ISO (MGI:MGI:2677561|PMID:14534243) MGI PMID:14534243 MGI:MGI:2677561 NCBI chr 3:45,906,668...46,000,721
Ensembl chr 3:45,906,673...46,000,187
JBrowse link
G LPAR5 lysophosphatidic acid receptor 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:64,049,470...64,060,289
Ensembl chr 5:64,058,501...64,059,604
JBrowse link
G OSM oncostatin M ISO (MGI:MGI:3574134|PMID:14985435) MGI PMID:14985435 MGI:MGI:3574134 NCBI chr14:47,242,767...47,246,836
Ensembl chr14:47,243,743...47,266,595
JBrowse link
G P2RX2 purinergic receptor P2X 2 IEA Ensembl GO_REF:0000107 NCBI chr14:22,854,828...22,858,574
Ensembl chr14:22,854,828...22,858,386
JBrowse link
G P2RX3 purinergic receptor P2X 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:13,584,913...13,619,652
Ensembl chr 2:13,585,926...13,617,769
JBrowse link
G P2RX4 purinergic receptor P2X 4 ISO PMID:12917686 ARUK-UCL PMID:12917686 RGD:13673840 NCBI chr14:31,368,542...31,387,960
Ensembl chr14:31,368,303...31,387,905
JBrowse link
G PIRT phosphoinositide interacting regulator of transient receptor potential channels IEA Ensembl GO_REF:0000107 NCBI chr12:55,513,291...55,526,290
Ensembl chr12:55,513,315...55,519,578
JBrowse link
G RUNX1 RUNX family transcription factor 1 ISO (MGI:MGI:3619829|PMID:16446141) MGI PMID:16446141 MGI:MGI:3619829 NCBI chr13:198,371,835...198,635,648
Ensembl chr13:198,371,835...198,638,189
JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr15:72,745,706...72,912,352
Ensembl chr15:72,748,692...72,912,407
JBrowse link
G TACR1 tachykinin receptor 1 ISO RGD PMID:18407414 RGD:2304276 NCBI chr 3:67,839,367...68,021,733
Ensembl chr 3:67,839,411...68,021,728
JBrowse link
G THBS1 thrombospondin 1 ISO (MGI:MGI:5516179|PMID:22745497) UniProtKB PMID:22745497 MGI:MGI:5516179 NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,781...131,746,115
JBrowse link
G THBS4 thrombospondin 4 ISO (MGI:MGI:5516179|PMID:22745497) UniProtKB
UniProt
PMID:22745497 MGI:MGI:5516179, RGD:8553360 NCBI chr 2:88,729,531...88,780,759
Ensembl chr 2:88,726,687...88,780,756
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 IEA Ensembl GO_REF:0000107 NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,701,325
JBrowse link
G TSPO translocator protein ISO RGD PMID:19555675 RGD:2317138 NCBI chr 5:5,723,190...5,735,097
Ensembl chr 5:5,723,186...5,735,128
JBrowse link
G VWA1 von Willebrand factor A domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:63,695,195...63,700,296
Ensembl chr 6:63,695,170...63,700,287
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    multicellular organismal process 8037
      multicellular organismal response to stress 105
        response to pain 40
          behavioral response to pain + 24
Path 2
Term Annotations click to browse term
  biological_process 16545
    response to stimulus 8984
      response to stress 3633
        multicellular organismal response to stress 105
          response to pain 40
            behavioral response to pain + 24
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.