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ONTOLOGY REPORT - ANNOTATIONS


Term:response to pain
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Accession:GO:0048265 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
Synonyms:exact_synonym: physiological response to pain
 alt_id: GO:0048267


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response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO (MGI:MGI:2153687|PMID:11718712) MGI PMID:11718712 MGI:MGI:2153687 NCBI chrNW_004936659:2,201,606...2,269,625 JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B ISO (MGI:MGI:3607758|PMID:12074836) MGI PMID:12074836 MGI:MGI:3607758 NCBI chrNW_004936669:133,488...308,623 JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO (MGI:MGI:3607758|PMID:12074836) MGI PMID:12074836 MGI:MGI:3607758 NCBI chrNW_004936481:7,694,960...7,908,683 JBrowse link
G Comt catechol-O-methyltransferase ISO RGD PMID:17084978 RGD:2289747 NCBI chrNW_004936619:3,847,059...3,883,866 JBrowse link
G Crh corticotropin releasing hormone ISO RGD PMID:21463663 RGD:5490545 NCBI chrNW_004936496:7,759,656...7,761,555 JBrowse link
G Dbh dopamine beta-hydroxylase ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chrNW_004936669:3,302,014...3,326,233 JBrowse link
G Ednrb endothelin receptor type B ISO RGD PMID:12847519 RGD:1581889 NCBI chrNW_004936511:3,446,864...3,478,434 JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO PMID:17057711 UniProt PMID:17057711 RGD:8554553 NCBI chrNW_004936697:232,048...275,420 JBrowse link
G Gja4 gap junction protein alpha 4 ISO RGD PMID:11978404 RGD:728686 NCBI chrNW_004936474:17,439,250...17,440,829 JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 ISO (MGI:MGI:2158115|PMID:11792319) MGI PMID:11792319 MGI:MGI:2158115 NCBI chrNW_004936744:91,833...167,214 JBrowse link
G Prkcg protein kinase C gamma ISO (MGI:MGI:1097759|PMID:9323205) UniProtKB PMID:9323205 MGI:MGI:1097759 NCBI chrNW_004936994:87,525...105,125 JBrowse link
G Reln reelin ISO (MGI:MGI:3625412|PMID:16580148) MGI PMID:16580148 MGI:MGI:3625412 NCBI chrNW_004936479:19,628,488...20,088,278 JBrowse link
G Ret ret proto-oncogene ISO (MGI:MGI:4441221|PMID:20237269) UniProtKB PMID:20237269 MGI:MGI:4441221 NCBI chrNW_004936617:2,927,185...2,980,594 JBrowse link
G Slc6a2 solute carrier family 6 member 2 ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chrNW_004936475:7,937,920...7,973,563 JBrowse link
G Tac1 tachykinin precursor 1 ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chrNW_004936585:2,932,783...2,941,141 JBrowse link
G Tacr1 tachykinin receptor 1 ISO (MGI:MGI:2157273|PMID:11805341) MGI PMID:11805341 MGI:MGI:2157273 NCBI chrNW_004936556:1,266,621...1,421,271 JBrowse link
G Trpa1 transient receptor potential cation channel subfamily A member 1 ISO (MGI:MGI:3790902|PMID:18272293)
(MGI:MGI:3623714|PMID:16630838), (MGI:MGI:3794274|PMID:18297068)
MGI PMID:16630838, PMID:18272293, PMID:18297068 MGI:MGI:3623714, MGI:MGI:3790902, MGI:MGI:3794274 NCBI chrNW_004936648:1,094,460...1,141,394 JBrowse link
G Trpv1 transient receptor potential cation channel subfamily V member 1 ISO (MGI:MGI:3790902|PMID:18272293)
(MGI:MGI:3794274|PMID:18297068)
MGI PMID:18272293, PMID:18297068 MGI:MGI:3790902, MGI:MGI:3794274 NCBI chrNW_004936677:277,304...326,907 JBrowse link
G Tspo translocator protein ISO RGD PMID:19555675 RGD:2317138 NCBI chrNW_004936718:992,301...995,172 JBrowse link
G Ucn urocortin ISO RGD PMID:21463663 RGD:5490545 NCBI chrNW_004936493:5,258,574...5,260,692 JBrowse link
behavioral response to formalin induced pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kalrn kalirin RhoGEF kinase ISO (MGI:MGI:5645427|PMID:25865668) MGI PMID:25865668 MGI:MGI:5645427 NCBI chrNW_004936725:566,560...774,208 JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO (MGI:MGI:5571523|PMID:24760869) MGI PMID:24760869 MGI:MGI:5571523 NCBI chrNW_004936580:6,002,168...6,021,690 JBrowse link
G P2rx3 purinergic receptor P2X 3 ISO RGD PMID:24120766 RGD:10043614 NCBI chrNW_004936581:5,116,276...5,146,378 JBrowse link
behavioral response to pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO (MGI:MGI:3664669|PMID:16890369) MGI PMID:16890369 MGI:MGI:3664669 NCBI chrNW_004936659:2,201,606...2,269,625 JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO (MGI:MGI:1858676|PMID:10801976) MGI PMID:10801976 MGI:MGI:1858676 NCBI chrNW_004936481:7,694,960...7,908,683 JBrowse link
G Capn2 calpain 2 ISO RGD PMID:25150005 RGD:13792585 NCBI chrNW_004936526:879,765...932,682 JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:17550594 RGD:1626231 NCBI chrNW_004936541:2,288,847...2,333,129 JBrowse link
G Git2 GIT ArfGAP 2 ISO (MGI:MGI:5506968|PMID:23870131) MGI PMID:23870131 MGI:MGI:5506968 NCBI chrNW_004936769:1,529,983...1,574,805 JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 ISO (MGI:MGI:3577154|PMID:15673679) MGI PMID:15673679 MGI:MGI:3577154 NCBI chrNW_004936500:12,157,215...12,536,555 JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO (MGI:MGI:3610653|PMID:11711849) MGI PMID:11711849 MGI:MGI:3610653 NCBI chrNW_004936587:3,406,055...3,806,956 JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 ISO RGD PMID:16098671 RGD:6480679 NCBI chrNW_004936601:3,569,626...3,626,782 JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 ISO (MGI:MGI:2677561|PMID:14534243) MGI PMID:14534243 MGI:MGI:2677561 NCBI chrNW_004936744:91,833...167,214 JBrowse link
G Lpar5 lysophosphatidic acid receptor 5 ISO (MGI:MGI:5429492|PMID:22461625) MGI PMID:22461625 MGI:MGI:5429492 NCBI chrNW_004936709:1,170,042...1,172,148 JBrowse link
G Osm oncostatin M ISO (MGI:MGI:3574134|PMID:14985435) MGI PMID:14985435 MGI:MGI:3574134 NCBI chrNW_004936904:390,089...394,195 JBrowse link
G P2rx2 purinergic receptor P2X 2 ISO (MGI:MGI:3656422|PMID:15961431) MGI PMID:15961431 MGI:MGI:3656422 NCBI chrNW_004936660:2,570,627...2,574,081 JBrowse link
G P2rx3 purinergic receptor P2X 3 ISO (MGI:MGI:1926736|PMID:11069182)
(MGI:MGI:3656422|PMID:15961431)
(MGI:MGI:1926735|PMID:11069181)
MGI PMID:11069181, PMID:11069182, PMID:15961431 MGI:MGI:1926735, MGI:MGI:1926736, MGI:MGI:3656422 NCBI chrNW_004936581:5,116,276...5,146,378 JBrowse link
G P2rx4 purinergic receptor P2X 4 ISO PMID:12917686 ARUK-UCL PMID:12917686 RGD:13673840 NCBI chrNW_004936558:3,062,279...3,077,493 JBrowse link
G Pirt phosphoinositide interacting regulator of transient receptor potential channels ISO (MGI:MGI:3834285|PMID:18455988) MGI PMID:18455988 MGI:MGI:3834285 NCBI chrNW_004936595:3,659,356...3,677,871 JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO (MGI:MGI:3052623|PMID:15314237) MGI PMID:15314237 MGI:MGI:3052623 NCBI chrNW_004936469:13,063,971...13,153,030 JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:18407414 RGD:2304276 NCBI chrNW_004936556:1,266,621...1,421,271 JBrowse link
G Thbs1 thrombospondin 1 ISO (MGI:MGI:5516179|PMID:22745497) UniProtKB PMID:22745497 MGI:MGI:5516179 NCBI chrNW_004936471:3,064,466...3,081,125 JBrowse link
G Thbs4 thrombospondin 4 ISO (MGI:MGI:5516179|PMID:22745497) UniProtKB
UniProt
PMID:22745497 MGI:MGI:5516179, RGD:8553360 NCBI chrNW_004936549:7,781,214...7,828,569 JBrowse link
G Trpv1 transient receptor potential cation channel subfamily V member 1 ISO (MGI:MGI:3834285|PMID:18455988)
(MGI:MGI:3763480|PMID:17767493), (MGI:MGI:3778264|PMID:18272658)
MGI PMID:17767493, PMID:18272658, PMID:18455988 MGI:MGI:3763480, MGI:MGI:3778264, MGI:MGI:3834285 NCBI chrNW_004936677:277,304...326,907 JBrowse link
G Tspo translocator protein ISO RGD PMID:19555675 RGD:2317138 NCBI chrNW_004936718:992,301...995,172 JBrowse link
G Vwa1 von Willebrand factor A domain containing 1 ISO (MGI:MGI:3849094|PMID:19279005) MGI PMID:19279005 MGI:MGI:3849094 NCBI chrNW_004936737:1,733,837...1,738,861 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11998
    multicellular organismal process 6221
      multicellular organismal response to stress 102
        response to pain 38
          behavioral response to pain + 24
Path 2
Term Annotations click to browse term
  biological_process 11998
    response to stimulus 6422
      response to stress 3059
        multicellular organismal response to stress 102
          response to pain 38
            behavioral response to pain + 24
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.