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ONTOLOGY REPORT - ANNOTATIONS


Term:isotype switching to IgE isotypes
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Accession:GO:0048289 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus.
Synonyms:exact_synonym: class switch recombination to IgE isotypes;   class switching to IgE isotypes;   isotype switch recombination to IgE isotypes


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negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link 18 31,574,759 31,625,286 RGD:1624291
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1624291
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clcf1 cardiotrophin-like cytokine factor 1 JBrowse link 1 219,468,866 219,472,445 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    immune system process 2611
      leukocyte activation 982
        lymphocyte activation 817
          lymphocyte activation involved in immune response 188
            B cell activation involved in immune response 81
              isotype switching 55
                isotype switching to IgE isotypes 7
                  interleukin-4-dependent isotype switching to IgE isotypes + 1
                  negative regulation of isotype switching to IgE isotypes 3
                  positive regulation of isotype switching to IgE isotypes + 4
                  regulation of isotype switching to IgE isotypes + 7
Path 2
Term Annotations click to browse term
  biological_process 19336
    metabolic process 11555
      cellular metabolic process 10567
        heterocycle metabolic process 5410
          nucleobase-containing compound metabolic process 5258
            nucleic acid metabolic process 4770
              DNA metabolic process 877
                DNA recombination 306
                  somatic cell DNA recombination 73
                    somatic diversification of immune receptors via germline recombination within a single locus 73
                      somatic recombination of immunoglobulin gene segments 60
                        somatic recombination of immunoglobulin genes involved in immune response 55
                          isotype switching 55
                            isotype switching to IgE isotypes 7
                              interleukin-4-dependent isotype switching to IgE isotypes + 1
                              negative regulation of isotype switching to IgE isotypes 3
                              positive regulation of isotype switching to IgE isotypes + 4
                              regulation of isotype switching to IgE isotypes + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.