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ONTOLOGY REPORT - ANNOTATIONS


Term:isotype switching to IgA isotypes
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Accession:GO:0048290 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus.
Synonyms:exact_synonym: class switching to IgA isotypes;   isotype switch recombination to IgA isotypes


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isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr6 C-C motif chemokine receptor 6 JBrowse link 1 53,063,380 53,087,519 RGD:1624291
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Da2-19 uncharacterized LOC302729 JBrowse link X 48,196,789 48,213,506 RGD:1600115
G Thoc1 THO complex 1 JBrowse link 18 1,142,540 1,177,084 RGD:1624291
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:1600115
RGD:1624291
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:1600115
RGD:1624291
G Nsd2 nuclear receptor binding SET domain protein 2 JBrowse link 14 82,119,210 82,196,501 RGD:1624291
G Pms2 PMS1 homolog 2, mismatch repair system component JBrowse link 12 12,714,394 12,738,654 RGD:1624291
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
G Tnfsf13 TNF superfamily member 13 JBrowse link 10 56,286,964 56,290,680 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    immune system process 2693
      leukocyte activation 1009
        lymphocyte activation 829
          lymphocyte activation involved in immune response 190
            B cell activation involved in immune response 82
              isotype switching 56
                isotype switching to IgA isotypes 9
                  negative regulation of isotype switching to IgA isotypes 2
                  positive regulation of isotype switching to IgA isotypes 6
                  regulation of isotype switching to IgA isotypes + 8
Path 2
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      cellular metabolic process 10737
        heterocycle metabolic process 5428
          nucleobase-containing compound metabolic process 5276
            nucleic acid metabolic process 4782
              DNA metabolic process 887
                DNA recombination 309
                  somatic cell DNA recombination 74
                    somatic diversification of immune receptors via germline recombination within a single locus 74
                      somatic recombination of immunoglobulin gene segments 61
                        somatic recombination of immunoglobulin genes involved in immune response 56
                          isotype switching 56
                            isotype switching to IgA isotypes 9
                              negative regulation of isotype switching to IgA isotypes 2
                              positive regulation of isotype switching to IgA isotypes 6
                              regulation of isotype switching to IgA isotypes + 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.