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ONTOLOGY REPORT - ANNOTATIONS


Term:isotype switching to IgG isotypes
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Accession:GO:0048291 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus.
Synonyms:exact_synonym: class switching to IgG isotypes;   isotype switch recombination to IgG isotypes


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isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:1624291
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atad5 ATPase family, AAA domain containing 5 JBrowse link 10 67,427,042 67,475,825 RGD:1624291
G Cd28 Cd28 molecule JBrowse link 9 67,546,408 67,573,858 RGD:1624291
RGD:1600115
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:1624291
RGD:13792537
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
RGD:13792537
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:1600115
RGD:1624291
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:1600115
RGD:1624291
G Pagr1 Paxip1-associated glutamate-rich protein 1 JBrowse link 1 198,448,790 198,451,078 RGD:1624291
G Paxip1 PAX interacting protein 1 JBrowse link 4 3,956,931 4,008,326 RGD:1624291
G Pms2 PMS1 homolog 2, mismatch repair system component JBrowse link 12 12,714,394 12,738,654 RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
G Il27ra interleukin 27 receptor subunit alpha JBrowse link 19 25,151,835 25,163,995 RGD:1624291
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link 18 31,574,759 31,625,286 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    immune system process 2693
      leukocyte activation 1009
        lymphocyte activation 829
          lymphocyte activation involved in immune response 190
            B cell activation involved in immune response 82
              isotype switching 56
                isotype switching to IgG isotypes 17
                  negative regulation of isotype switching to IgG isotypes 0
                  positive regulation of isotype switching to IgG isotypes 13
                  regulation of isotype switching to IgG isotypes + 16
Path 2
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      cellular metabolic process 10737
        heterocycle metabolic process 5428
          nucleobase-containing compound metabolic process 5276
            nucleic acid metabolic process 4782
              DNA metabolic process 887
                DNA recombination 309
                  somatic cell DNA recombination 74
                    somatic diversification of immune receptors via germline recombination within a single locus 74
                      somatic recombination of immunoglobulin gene segments 61
                        somatic recombination of immunoglobulin genes involved in immune response 56
                          isotype switching 56
                            isotype switching to IgG isotypes 17
                              negative regulation of isotype switching to IgG isotypes 0
                              positive regulation of isotype switching to IgG isotypes 13
                              regulation of isotype switching to IgG isotypes + 16
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.