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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of isotype switching to IgE isotypes
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Accession:GO:0048294 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes.
Synonyms:exact_synonym: down regulation of isotype switching to IgE isotypes;   downregulation of isotype switching to IgE isotypes;   negative regulation of class switch recombination to IgE isotypes;   negative regulation of class switching to IgE isotypes;   negative regulation of isotype switch recombination to IgE isotypes
 narrow_synonym: inhibition of isotype switching to IgE isotypes


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negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL6 BCL6 transcription repressor JBrowse link 3 187,721,377 187,745,472 RGD:2290271
G FOXP3 forkhead box P3 JBrowse link X 49,250,436 49,264,932 RGD:2290271
G NDFIP1 Nedd4 family interacting protein 1 JBrowse link 5 142,108,779 142,154,440 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17988
    developmental process 6548
      negative regulation of developmental process 984
        negative regulation of isotype switching 5
          negative regulation of isotype switching to IgE isotypes 3
Path 2
Term Annotations click to browse term
  biological_process 17988
    metabolic process 11592
      cellular metabolic process 10880
        cellular aromatic compound metabolic process 6012
          nucleobase-containing compound metabolic process 5789
            nucleic acid metabolic process 5254
              DNA metabolic process 961
                DNA recombination 299
                  somatic cell DNA recombination 67
                    somatic diversification of immune receptors via germline recombination within a single locus 67
                      somatic recombination of immunoglobulin gene segments 55
                        somatic recombination of immunoglobulin genes involved in immune response 50
                          isotype switching 50
                            regulation of isotype switching 36
                              negative regulation of isotype switching 5
                                negative regulation of isotype switching to IgE isotypes 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.