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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of isotype switching to IgE isotypes
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Accession:GO:0048294 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes.
Synonyms:exact_synonym: down regulation of isotype switching to IgE isotypes;   downregulation of isotype switching to IgE isotypes;   negative regulation of class switch recombination to IgE isotypes;   negative regulation of class switching to IgE isotypes;   negative regulation of isotype switch recombination to IgE isotypes
 narrow_synonym: inhibition of isotype switching to IgE isotypes


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negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl6 B cell leukemia/lymphoma 6 JBrowse link 16 23,965,050 23,988,866 RGD:2290270
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:2290270
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link 18 38,418,907 38,465,197 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23017
    developmental process 6306
      negative regulation of developmental process 1070
        negative regulation of isotype switching 5
          negative regulation of isotype switching to IgE isotypes 3
Path 2
Term Annotations click to browse term
  biological_process 23017
    metabolic process 10332
      cellular metabolic process 9317
        cellular aromatic compound metabolic process 4857
          nucleobase-containing compound metabolic process 4647
            nucleic acid metabolic process 4221
              DNA metabolic process 823
                DNA recombination 282
                  somatic cell DNA recombination 67
                    somatic diversification of immune receptors via germline recombination within a single locus 67
                      somatic recombination of immunoglobulin gene segments 58
                        somatic recombination of immunoglobulin genes involved in immune response 53
                          isotype switching 53
                            regulation of isotype switching 37
                              negative regulation of isotype switching 5
                                negative regulation of isotype switching to IgE isotypes 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.