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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of isotype switching to IgE isotypes
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Accession:GO:0048294 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes.
Synonyms:exact_synonym: down regulation of isotype switching to IgE isotypes;   downregulation of isotype switching to IgE isotypes;   negative regulation of class switch recombination to IgE isotypes;   negative regulation of class switching to IgE isotypes;   negative regulation of isotype switch recombination to IgE isotypes
 narrow_synonym: inhibition of isotype switching to IgE isotypes


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negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL6 BCL6 transcription repressor JBrowse link 13 125,377,247 125,401,328 RGD:14298760
G FOXP3 forkhead box P3 JBrowse link X 43,303,777 43,328,164 RGD:14298760
G NDFIP1 Nedd4 family interacting protein 1 JBrowse link 2 143,688,946 143,734,523 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14401
    developmental process 4177
      negative regulation of developmental process 669
        negative regulation of isotype switching 4
          negative regulation of isotype switching to IgE isotypes 3
Path 2
Term Annotations click to browse term
  biological_process 14401
    metabolic process 8874
      cellular metabolic process 8120
        cellular aromatic compound metabolic process 4244
          nucleobase-containing compound metabolic process 4102
            nucleic acid metabolic process 3759
              DNA metabolic process 645
                DNA recombination 221
                  somatic cell DNA recombination 50
                    somatic diversification of immune receptors via germline recombination within a single locus 50
                      somatic recombination of immunoglobulin gene segments 42
                        somatic recombination of immunoglobulin genes involved in immune response 37
                          isotype switching 37
                            regulation of isotype switching 29
                              negative regulation of isotype switching 4
                                negative regulation of isotype switching to IgE isotypes 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.