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ONTOLOGY REPORT - ANNOTATIONS


Term:mesodermal cell differentiation
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Accession:GO:0048333 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.
Synonyms:exact_synonym: mesoderm cell differentiation


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mesodermal cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO (MGI:70235|PMID:7799920) RGD PMID:7799920 MGI:70235 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IEP RGD PMID:7803853 RGD:632663 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Hmga2 high mobility group AT-hook 2 ISO
ISS
(PMID:17624332)
GO_REF:0000024
RGD
UniProt
PMID:17624332 GO_REF:0000024 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G Inhba inhibin subunit beta A ISO (MGI:70235|PMID:7799920) RGD PMID:7799920 MGI:70235 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Itga2 integrin subunit alpha 2 ISO (PMID:23154389) RGD PMID:23154389 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itga3 integrin subunit alpha 3 ISO (PMID:23154389) RGD PMID:23154389 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itga8 integrin subunit alpha 8 ISO (PMID:23154389) RGD PMID:23154389 NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
JBrowse link
G Itgb1 integrin subunit beta 1 IEA
ISO
GO_REF:0000107
(PMID:23154389)
Ensembl
RGD
PMID:23154389 GO_REF:0000107 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb3 integrin subunit beta 3 ISO (PMID:23154389) RGD PMID:23154389 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Itgb4 integrin subunit beta 4 IEA
ISO
GO_REF:0000107
(PMID:23154389)
Ensembl
RGD
PMID:23154389 GO_REF:0000107 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Kdm6a lysine demethylase 6A ISO MGI:5448754|MGI:5448825 (MGI:5448135|PMID:22949634) RGD PMID:22949634 MGI:5448135 NCBI chr  X:4,805,493...4,945,788
Ensembl chr  X:4,806,277...4,945,944
JBrowse link
G Kdm6b lysine demethylase 6B ISO (MGI:5574281|PMID:23856522) RGD PMID:23856522 MGI:5574281 NCBI chr10:56,000,494...56,009,582
Ensembl chr10:56,001,799...56,008,885
JBrowse link
axial mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nodal nodal growth differentiation factor ISO (MGI:2677178|PMID:14511481) RGD PMID:14511481 MGI:2677178 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
BMP signaling pathway involved in mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Etv2 ETS variant transcription factor 2 ISO (MGI:4415813|PMID:18462699) RGD PMID:18462699 MGI:4415813 NCBI chr 1:89,091,239...89,094,570
Ensembl chr 1:89,091,239...89,094,530
JBrowse link
hemangioblast cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor ISO MGI:1857254 (MGI:3580923|PMID:15677567), (MGI:3807430|PMID:18550854), (MGI:3838687|PMID:19182774) RGD PMID:15677567, PMID:18550854, PMID:19182774 MGI:3580923, MGI:3807430, MGI:3838687 NCBI chr 5:133,864,401...133,878,604
Ensembl chr 5:133,864,798...133,878,830
JBrowse link
intermediate mesodermal cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IEA
ISO
ISS
GO_REF:0000107
(PMID:10021330)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:10021330 GO_REF:0000024, GO_REF:0000107 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
lateral mesodermal cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxf1 forkhead box F1 ISO MGI:1929432 (MGI:1928688|PMID:11124112) RGD PMID:11124112 MGI:1928688 NCBI chr19:53,012,306...53,016,100
Ensembl chr19:53,012,332...53,016,086
JBrowse link
mesodermal cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nanog Nanog homeobox ISO MGI:109452 (MGI:3654744|PMID:16801560) RGD PMID:16801560 MGI:3654744 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO (MGI:1355046|PMID:10742100) RGD PMID:10742100 MGI:1355046 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Smad1 SMAD family member 1 IEA
ISO
GO_REF:0000107
MGI:1919200 (MGI:3654744|PMID:16801560)
Ensembl
RGD
PMID:16801560 GO_REF:0000107, MGI:3654744 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
mesodermal cell fate determination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IEA
ISO
GO_REF:0000107
MGI:1857137 (MGI:76261|PMID:7657163)
Ensembl
RGD
PMID:7657163 GO_REF:0000107, MGI:76261 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 ISO (MGI:3768605|PMID:17785448) RGD PMID:17785448 MGI:3768605 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G Hoxa11 homeobox A11 ISO (MGI:3768605|PMID:17785448) RGD PMID:17785448 MGI:3768605 NCBI chr 4:82,296,888...82,301,419
Ensembl chr 4:82,298,152...82,300,503
Ensembl chr 4:82,298,152...82,300,503
JBrowse link
G Pax2 paired box 2 ISS
ISO
GO_REF:0000024
(MGI:3768605|PMID:17785448)
UniProt
RGD
PMID:17785448 GO_REF:0000024, MGI:3768605 NCBI chr 1:264,493,579...264,585,073
Ensembl chr 1:264,504,591...264,583,329
JBrowse link
G Six2 SIX homeobox 2 ISO (MGI:3768605|PMID:17785448) RGD PMID:17785448 MGI:3768605 NCBI chr 6:8,952,572...8,955,893
Ensembl chr 6:8,952,572...8,956,276
JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 ISO MGI:98956 (MGI:3711603|PMID:17462603) RGD PMID:17462603 MGI:3711603 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
paraxial mesodermal cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxc2 forkhead box C2 ISO MGI:1857865 (MGI:86990|PMID:9106663) RGD PMID:9106663 MGI:86990 NCBI chr19:53,044,379...53,047,081
Ensembl chr19:53,044,379...53,047,081
JBrowse link
G Wnt3a Wnt family member 3A ISO MGI:1857489 (MGI:86727|PMID:9126297) RGD PMID:9126297 MGI:86727 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
positive regulation of mesodermal cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 ISO (PMID:30599359) RGD PMID:30599359 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A ISO MGI:95522 (MGI:3702797|PMID:16943278) RGD PMID:16943278 MGI:3702797 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IEA
ISO
GO_REF:0000107
MGI:1338938 (MGI:3702797|PMID:16943278)
Ensembl
RGD
PMID:16943278 GO_REF:0000107, MGI:3702797 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cellular developmental process 4457
        cell differentiation 4362
          mesodermal cell differentiation 31
            axial mesodermal cell differentiation + 1
            hemangioblast cell differentiation 1
            intermediate mesodermal cell differentiation + 1
            lateral mesodermal cell differentiation + 3
            mesodermal cell fate commitment + 17
            negative regulation of mesodermal cell differentiation + 3
            paraxial mesodermal cell differentiation + 2
            positive regulation of mesodermal cell differentiation + 2
            regulation of mesodermal cell differentiation + 7
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          embryo development 1307
            embryonic morphogenesis 690
              gastrulation 208
                formation of primary germ layer 128
                  mesoderm formation 75
                    mesodermal cell differentiation 31
                      axial mesodermal cell differentiation + 1
                      hemangioblast cell differentiation 1
                      intermediate mesodermal cell differentiation + 1
                      lateral mesodermal cell differentiation + 3
                      mesodermal cell fate commitment + 17
                      negative regulation of mesodermal cell differentiation + 3
                      paraxial mesodermal cell differentiation + 2
                      positive regulation of mesodermal cell differentiation + 2
                      regulation of mesodermal cell differentiation + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.