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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of smooth muscle cell proliferation
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Accession:GO:0048662 term browser browse the term
Definition:Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
Synonyms:exact_synonym: down regulation of smooth muscle cell proliferation;   downregulation of smooth muscle cell proliferation;   negative regulation of SMC proliferation
 narrow_synonym: inhibition of smooth muscle cell proliferation


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negative regulation of smooth muscle cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 IMP RGD PMID:20703229 RGD:9685431 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Aif1 allograft inflammatory factor 1 ISO (PMID:22116621), (PMID:9614071) RGD PMID:9614071, PMID:22116621 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Ang angiogenin ISO (PMID:10103013) RGD PMID:10103013 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Apod apolipoprotein D IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:14551159)
Ensembl
UniProt
RGD
PMID:14551159 GO_REF:0000024, GO_REF:0000107 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G Cav1 caveolin 1 IMP RGD PMID:20828553 RGD:6849298 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Comt catechol-O-methyltransferase IMP RGD PMID:11071850 RGD:2289790 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 ISO (MGI:MGI:4821071|PMID:17122440) RGD PMID:17122440 MGI:MGI:4821071 NCBI chr 5:166,464,170...166,513,030
Ensembl chr 5:166,464,252...166,513,027
JBrowse link
G Esr1 estrogen receptor 1 IMP RGD PMID:22099601 RGD:8553200 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 IMP RGD PMID:22099601 RGD:8553200 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Hmox1 heme oxygenase 1 IMP
ISO
(PMID:17600318) RGD PMID:17600318, PMID:19885007 RGD:4145298 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma ISO (PMID:16942485) RGD PMID:16942485 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 ISO
IEA
(PMID:10766744)
GO_REF:0000107
RGD
Ensembl
PMID:10766744 GO_REF:0000107 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 ISO (PMID:10766744) RGD PMID:10766744 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Il12a interleukin 12A ISO
IEA
(PMID:16942485)
GO_REF:0000107
RGD
Ensembl
PMID:16942485 GO_REF:0000107 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B ISO (PMID:16942485) RGD PMID:16942485 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il15 interleukin 15 IMP RGD PMID:17667861 RGD:5013835 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Ilk integrin-linked kinase IMP reduction of wound healing in culture RGD PMID:18535176 RGD:2301740 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Klf4 Kruppel like factor 4 IDA
IMP
vascular smooth muscle cell
PMID:19531492
RGD
UniProt
PMID:17659301, PMID:19531492 RGD:1643591, RGD:8553301 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G LOC100911485 mitofusin-2-like IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:164,560,437...164,586,254
Ensembl chr 5:164,562,149...164,585,634
JBrowse link
G Mfn2 mitofusin 2 IEA
IDA
GO_REF:0000002
PMID:15322553
InterPro PMID:15322553 GO_REF:0000002, RGD:1304351 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Ndrg2 NDRG family member 2 ISO
IEA
(MGI:MGI:3655783|PMID:16520977)
GO_REF:0000107
RGD
Ensembl
PMID:16520977 GO_REF:0000107, MGI:MGI:3655783 NCBI chr15:28,305,820...28,314,459
Ensembl chr15:28,305,821...28,314,459
JBrowse link
G Ndrg4 NDRG family member 4 ISO
IEA
(PMID:12755708)
GO_REF:0000107
RGD
Ensembl
PMID:12755708 GO_REF:0000107 NCBI chr19:9,766,439...9,802,396
Ensembl chr19:9,766,439...9,801,942
JBrowse link
G NEWGENE_1308171 osteoglycin IMP PMID:21519924 UniProt PMID:21519924 RGD:8554796 NCBI chr17:15,447,716...15,468,793
Ensembl chr17:15,447,716...15,467,359
Ensembl chr17:15,447,716...15,467,359
JBrowse link
G Nos3 nitric oxide synthase 3 IMP
ISO
IEA
MGI:MGI:1857229 (MGI:MGI:4462731|PMID:20554900)
GO_REF:0000107
RGD
Ensembl
PMID:20554900, PMID:12388111, PMID:14871555 GO_REF:0000107, MGI:MGI:4462731, RGD:628542, RGD:1580270 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppb natriuretic peptide B IDA RGD PMID:19104909 RGD:2324682 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Npr1 natriuretic peptide receptor 1 IMP RGD PMID:19104909 RGD:2324682 NCBI chr 2:189,840,403...189,857,032
Ensembl chr 2:189,840,403...189,856,090
JBrowse link
G Npr3 natriuretic peptide receptor 3 IMP RGD PMID:21457229 RGD:7327141 NCBI chr 2:61,883,946...61,950,291
Ensembl chr 2:61,888,950...61,949,926
JBrowse link
G Ogn osteoglycin IMP PMID:21519924 UniProt PMID:21519924 RGD:8554796 NCBI chr17:14,607,442...14,628,274
Ensembl chr17:15,447,716...15,467,359
Ensembl chr17:15,447,716...15,467,359
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IMP cAMP-dependent RGD PMID:19783773 RGD:4107736 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta IDA RGD PMID:18585719 RGD:2324882 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO (PMID:20622039) RGD PMID:20622039 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IMP RGD PMID:19142226 RGD:10059645 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgir prostaglandin I2 receptor ISO
IBA
(PMID:20622039)
PMID:21873635
(MGI:MGI:5437428|PMID:20622039)
RGD PMID:20622039, PMID:21873635 MGI:MGI:5437428, RGD:13792537 NCBI chr 1:78,833,449...78,835,832
Ensembl chr 1:78,833,157...78,837,623
JBrowse link
G Ralbp1 ralA binding protein 1 IMP RGD PMID:16648138 RGD:1626091 NCBI chr 9:113,579,107...113,598,477
Ensembl chr 9:113,579,107...113,598,480
JBrowse link
G Sf1 splicing factor 1 IMP RGD PMID:11748220 RGD:632653 NCBI chr 1:221,735,512...221,749,216
Ensembl chr 1:221,735,517...221,749,086
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO (PMID:16816117) RGD PMID:16816117 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tp53 tumor protein p53 IMP RGD PMID:17659301 RGD:1643591 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib1 tribbles pseudokinase 1 ISO (PMID:17452330) RGD PMID:17452330 NCBI chr 7:99,954,492...99,961,026
Ensembl chr 7:99,954,492...99,961,026
JBrowse link
G Vip vasoactive intestinal peptide IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:20452385, PMID:21873635 RGD:5685633, RGD:13792537 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
JBrowse link
G Vipr2 vasoactive intestinal peptide receptor 2 IMP RGD PMID:20452385 RGD:5685633 NCBI chr 6:143,932,960...144,009,476
Ensembl chr 6:143,938,040...144,008,072
JBrowse link
negative regulation of vascular associated smooth muscle cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO
ISS
(PMID:12070119)
GO_REF:0000024
RGD
UniProt
PMID:12070119 GO_REF:0000024 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Apln apelin ISO (PMID:23263626) RGD PMID:23263626 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO (PMID:25681685) RGD PMID:25681685 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B ISO (PMID:19088079) RGD PMID:19088079 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cnn1 calponin 1 ISO UniProtKB:P17861-2 (PMID:26315405) RGD PMID:26315405 NCBI chr 8:23,113,083...23,121,748
Ensembl chr 8:23,113,048...23,121,761
JBrowse link
G Drd4 dopamine receptor D4 IDA RGD PMID:24888351 RGD:13506962 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO
IEA
(PMID:23840305)
GO_REF:0000107
RGD
Ensembl
PMID:23840305 GO_REF:0000107 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Gstp1 glutathione S-transferase pi 1 IMP RGD PMID:24321768 RGD:10401938 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmox1 heme oxygenase 1 IMP RGD PMID:22709785 RGD:10755720 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il10 interleukin 10 ISO UniProtKB:P06804 (MGI:MGI:5796069|PMID:26808574) RGD PMID:26808574 MGI:MGI:5796069 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Mef2c myocyte enhancer factor 2C ISO
IEA
RNAcentral:URS000001C659_9606|RNAcentral:URS000075BB59_9606 (PMID:26184978), (PMID:28799067)
GO_REF:0000107
RGD
Ensembl
PMID:26184978, PMID:28799067 GO_REF:0000107 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:28478070 RGD:12910733 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mir125a microRNA 125a IDA RGD PMID:29700287 RGD:26884455 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
G Mir223 microRNA 223 IDA RGD PMID:30246291 RGD:25823198 NCBI chr  X:65,367,812...65,367,921
Ensembl chr  X:65,367,812...65,367,921
JBrowse link
G Myocd myocardin IEA
ISO
GO_REF:0000107
(MGI:MGI:5644147|PMID:23825366)
Ensembl
RGD
PMID:23825366 GO_REF:0000107, MGI:MGI:5644147 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986
JBrowse link
G Pdcd4 programmed cell death 4 ISO (PMID:28522568) RGD PMID:28522568 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO (PMID:24960162), (PMID:28522568) RGD PMID:24960162, PMID:28522568 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 ISO (PMID:25447536) RGD PMID:25447536 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Pten phosphatase and tensin homolog ISO (PMID:26208095) RGD PMID:26208095 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Rgs5 regulator of G-protein signaling 5 IDA RGD PMID:18207159 RGD:13524535 NCBI chr13:87,966,820...88,002,831
Ensembl chr13:87,966,758...88,003,035
JBrowse link
G Sod2 superoxide dismutase 2 ISO (PMID:27021683) RGD PMID:27021683 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfb3 transforming growth factor, beta 3 ISO (PMID:26315405) RGD PMID:26315405 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tpm1 tropomyosin 1 ISO
IEA
(PMID:21817107)
GO_REF:0000107
RGD
Ensembl
PMID:21817107 GO_REF:0000107 NCBI chr 8:72,814,737...72,841,496
Ensembl chr 8:72,814,740...72,842,228
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    negative regulation of biological process 5696
      negative regulation of cellular process 5144
        negative regulation of cell population proliferation 733
          negative regulation of smooth muscle cell proliferation 60
            negative regulation of vascular associated smooth muscle cell proliferation 23
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        negative regulation of biological process 5696
          negative regulation of cellular process 5144
            negative regulation of cell population proliferation 733
              negative regulation of smooth muscle cell proliferation 60
                negative regulation of vascular associated smooth muscle cell proliferation 23
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.