Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:neuron fate specification
go back to main search page
Accession:GO:0048665 term browser browse the term
Definition:The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


show annotations for term's descendants           Sort by:
 
neuron fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 ISS
ISO
GO_REF:0000024
MGI:1857470 (MGI:3639051|PMID:16469766), (MGI:5897542|PMID:24243019)
UniProt
RGD
PMID:16469766, PMID:24243019 GO_REF:0000024, MGI:3639051, MGI:5897542 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Dll1 delta like canonical Notch ligand 1 IEA
ISO
ISS
GO_REF:0000107
(MGI:3823133|PMID:18997111)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:18997111 GO_REF:0000024, GO_REF:0000107, MGI:3823133 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Dmrta2 DMRT-like family A2 ISO (MGI:5013657|PMID:21576465) RGD PMID:21576465 MGI:5013657 NCBI chr 5:129,754,295...129,760,045
Ensembl chr 5:129,756,149...129,758,986
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 ISO MGI:4418499 (MGI:5577209|PMID:24584053) RGD PMID:24584053 MGI:5577209 NCBI chr20:4,576,033...4,592,980
Ensembl chr20:4,576,057...4,592,980
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 ISO MGI:102780 (MGI:5319720|PMID:22513373) RGD PMID:22513373 MGI:5319720 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G Fev FEV transcription factor, ETS family member ISO MGI:2449922 (MGI:4836772|PMID:20818386) RGD PMID:20818386 MGI:4836772 NCBI chr 9:82,142,981...82,146,855
Ensembl chr 9:82,142,981...82,146,874
JBrowse link
G Foxa1 forkhead box A1 IEA
ISO
GO_REF:0000107
MGI:1347476 (MGI:3720545|PMID:17596284)
Ensembl
RGD
PMID:17596284 GO_REF:0000107, MGI:3720545 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Foxa2 forkhead box A2 ISO MGI:1347472|MGI:2176222|MGI:2177337 (MGI:3720545|PMID:17596284), (MGI:3767119|PMID:17922007) RGD PMID:17596284, PMID:17922007 MGI:3720545, MGI:3767119 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Gsx2 GS homeobox 2 ISO MGI:2150162 (MGI:3579956|PMID:15930101) RGD PMID:15930101 MGI:3579956 NCBI chr14:35,650,985...35,652,709
Ensembl chr14:35,650,985...35,652,709
JBrowse link
G Isl1 ISL LIM homeobox 1 IBA
ISO
PMID:21873635
(MGI:3815381|PMID:18849985)
RGD PMID:18849985, PMID:21873635 MGI:3815381, RGD:13792537 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Isl2 ISL LIM homeobox 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:60,117,565...60,122,716
Ensembl chr 8:60,117,729...60,122,211
JBrowse link
G Myt1l myelin transcription factor 1-like ISS
ISO
GO_REF:0000024
(MGI:5897487|PMID:28379941), (MGI:5897542|PMID:24243019)
UniProt
RGD
PMID:24243019, PMID:28379941 GO_REF:0000024, MGI:5897487, MGI:5897542 NCBI chr 6:48,452,385...48,843,443
Ensembl chr 6:48,452,369...48,857,936
JBrowse link
G Nkx2-2 NK2 homeobox 2 ISO MGI:1932100|MGI:97451 (MGI:3611719|PMID:16339193), (MGI:4360136|PMID:19592574) RGD PMID:16339193, PMID:19592574 MGI:3611719, MGI:4360136 NCBI chr 3:141,408,460...141,419,083
Ensembl chr 3:141,408,798...141,411,170
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 IMP RGD PMID:15247919 RGD:2325628 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Pou3f2 POU class 3 homeobox 2 IEA
ISO
ISS
GO_REF:0000107
(MGI:5897542|PMID:24243019)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:24243019 GO_REF:0000024, GO_REF:0000107, MGI:5897542 NCBI chr 5:36,677,452...36,683,356
Ensembl chr 5:36,681,528...36,683,356
JBrowse link
G Pou4f1 POU class 4 homeobox 1 IEA
ISO
GO_REF:0000107
(MGI:4367920|PMID:19877281), (MGI:4454975|PMID:20096094)
Ensembl
RGD
PMID:19877281, PMID:20096094 GO_REF:0000107, MGI:4367920, MGI:4454975 NCBI chr15:88,618,255...88,622,712
Ensembl chr15:88,620,470...88,622,413
JBrowse link
G Six1 SIX homeobox 1 ISO MGI:109344 (MGI:5319720|PMID:22513373) RGD PMID:22513373 MGI:5319720 NCBI chr 6:95,929,060...95,934,296
Ensembl chr 6:95,929,060...95,934,296
JBrowse link
G Tlx3 T-cell leukemia, homeobox 3 ISO MGI:104867 (MGI:3607682|PMID:16234809) RGD PMID:16234809 MGI:3607682 NCBI chr10:18,128,869...18,131,745
Ensembl chr10:18,129,408...18,131,562
JBrowse link
auditory receptor cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh1 atonal bHLH transcription factor 1 ISO MGI:2155983 (MGI:1339217|PMID:10364557) RGD PMID:10364557 MGI:1339217 NCBI chr 4:95,498,003...95,500,098
Ensembl chr 4:95,498,003...95,500,089
JBrowse link
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esrp1 epithelial splicing regulatory protein 1 ISS
ISO
GO_REF:0000024
(MGI:5915403|PMID:29107558)
UniProt
RGD
PMID:29107558 GO_REF:0000024, MGI:5915403 NCBI chr 5:24,576,988...24,631,758
Ensembl chr 5:24,576,991...24,631,698
JBrowse link
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO MGI:95729 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Gli3 GLI family zinc finger 3 ISO MGI:95728 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO MGI:4840420 (MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:4355593 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO MGI:95729 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Gli3 GLI family zinc finger 3 ISO MGI:95728 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO MGI:4840420 (MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:4355593 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link
spinal cord motor neuron cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxc10 homeo box C10 ISO MGI:96202 (MGI:3771768|PMID:18065432) RGD PMID:18065432 MGI:3771768 NCBI chr 7:144,577,578...144,582,802
Ensembl chr 7:144,577,465...144,582,622
JBrowse link
G Hoxd10 homeo box D10 ISO MGI:96192 (MGI:3771768|PMID:18065432) RGD PMID:18065432 MGI:3771768 NCBI chr 3:61,614,133...61,617,342
Ensembl chr 3:61,613,774...61,617,367
JBrowse link
G Isl1 ISL LIM homeobox 1 ISO MGI:102673 (MGI:4356383|PMID:19666821) RGD PMID:19666821 MGI:4356383 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Isl2 ISL LIM homeobox 2 IEA
ISO
GO_REF:0000107
MGI:102673 (MGI:4356383|PMID:19666821)
Ensembl
RGD
PMID:19666821 GO_REF:0000107, MGI:4356383 NCBI chr 8:60,117,565...60,122,716
Ensembl chr 8:60,117,729...60,122,211
JBrowse link
G Lhx3 LIM homeobox 3 ISO MGI:101791|MGI:109156 (MGI:4356383|PMID:19666821) RGD PMID:19666821 MGI:4356383 NCBI chr 3:3,653,861...3,662,509
Ensembl chr 3:3,654,755...3,661,810
JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 IBA
ISO
PMID:21873635
MGI:2182358|MGI:2182361|MGI:2182363 (MGI:1344237|PMID:10482234)
RGD PMID:10482234, PMID:21873635 MGI:1344237, RGD:13792537 NCBI chr 4:2,376,350...2,381,308
Ensembl chr 4:2,376,958...2,381,271
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 ISO MGI:3573868 (MGI:3531376|PMID:15769945) RGD PMID:15769945 MGI:3531376 NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835
JBrowse link
ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbx1 developing brain homeobox 1 ISO MGI:2182329 (MGI:2136554|PMID:11239429) RGD PMID:11239429 MGI:2136554 NCBI chr 1:104,969,218...104,973,648
Ensembl chr 1:104,969,218...104,973,648
JBrowse link
G Dmrt3 doublesex and mab-3 related transcription factor 3 ISO MGI:4420993 (MGI:5435948|PMID:22932389) RGD PMID:22932389 MGI:5435948 NCBI chr 1:243,589,607...243,602,926
Ensembl chr 1:243,589,607...243,602,926
JBrowse link
G Lhx3 LIM homeobox 3 ISO (MGI:4356383|PMID:19666821) RGD PMID:19666821 MGI:4356383 NCBI chr 3:3,653,861...3,662,509
Ensembl chr 3:3,654,755...3,661,810
JBrowse link
G Shh sonic hedgehog signaling molecule IDA PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Sox1 SRY-box transcription factor 1 ISO MGI:3653406 (MGI:4834949|PMID:20844123) RGD PMID:20844123 MGI:4834949

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cellular developmental process 4457
        cell fate specification 100
          neuron fate specification 32
            auditory receptor cell fate specification + 2
            photoreceptor cell fate specification + 0
            spinal cord association neuron specification 0
            spinal cord commissural neuron specification 0
            spinal cord motor neuron cell fate specification + 10
            ventral spinal cord interneuron specification + 8
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            nervous system development 2719
              neurogenesis 1936
                generation of neurons 1780
                  neuron differentiation 1614
                    neuron fate commitment 74
                      neuron fate specification 32
                        auditory receptor cell fate specification + 2
                        photoreceptor cell fate specification + 0
                        spinal cord association neuron specification 0
                        spinal cord commissural neuron specification 0
                        spinal cord motor neuron cell fate specification + 10
                        ventral spinal cord interneuron specification + 8
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.