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ONTOLOGY REPORT - ANNOTATIONS


Term:neuron fate specification
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Accession:GO:0048665 term browser browse the term
Definition:The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


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neuron fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ascl1 achaete-scute family bHLH transcription factor 1 JBrowse link 7 28,038,662 28,040,504 RGD:1600115
RGD:1624291
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:1600115
RGD:1624291
G Dmrta2 DMRT-like family A2 JBrowse link 5 129,754,295 129,760,045 RGD:1624291
G Ehmt2 euchromatic histone lysine methyltransferase 2 JBrowse link 20 4,576,033 4,592,980 RGD:1624291
RGD:1600115
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:1624291
RGD:1600115
G Fev FEV transcription factor, ETS family member JBrowse link 9 82,142,981 82,146,855 RGD:1624291
G Foxa1 forkhead box A1 JBrowse link 6 78,516,579 78,549,669 RGD:1624291
RGD:1600115
G Foxa2 forkhead box A2 JBrowse link 3 142,383,084 142,387,493 RGD:1624291
G Gsx2 GS homeobox 2 JBrowse link 14 35,650,985 35,652,709 RGD:1624291
RGD:1600115
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:1624291
RGD:13792537
G Isl2 ISL LIM homeobox 2 JBrowse link 8 60,117,565 60,122,716 RGD:13792537
G Myt1l myelin transcription factor 1-like JBrowse link 6 48,452,385 48,843,443 RGD:1600115
RGD:1624291
G Nkx2-2 NK2 homeobox 2 JBrowse link 3 141,408,460 141,419,083 RGD:1624291
RGD:1600115
G Ntrk3 neurotrophic receptor tyrosine kinase 3 JBrowse link 1 139,890,537 140,262,503 RGD:2325628
G Pou3f2 POU class 3 homeobox 2 JBrowse link 5 36,677,452 36,683,356 RGD:1600115
RGD:1624291
G Pou4f1 POU class 4 homeobox 1 JBrowse link 15 88,618,255 88,622,712 RGD:1624291
RGD:1600115
G Six1 SIX homeobox 1 JBrowse link 6 95,929,060 95,934,296 RGD:1624291
RGD:1600115
G Tlx3 T-cell leukemia, homeobox 3 JBrowse link 10 18,128,869 18,131,745 RGD:1624291
RGD:1600115
auditory receptor cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atoh1 atonal bHLH transcription factor 1 JBrowse link 4 95,498,003 95,500,098 RGD:1624291
RGD:1600115
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Esrp1 epithelial splicing regulatory protein 1 JBrowse link 5 24,576,988 24,631,758 RGD:1600115
RGD:1624291
regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lbx1 ladybird homeobox 1 JBrowse link 1 264,973,315 264,975,132 RGD:1624291
RGD:1600115
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nkx6-1 NK6 homeobox 1 JBrowse link 14 9,555,264 9,562,197 RGD:1624291
RGD:1600115
G Nkx6-2 NK6 homeobox 2 JBrowse link 1 211,922,389 211,923,929 RGD:1624291
RGD:1600115
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:1624291
RGD:1600115
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Evx1 even-skipped homeobox 1 JBrowse link 4 82,370,829 82,374,313 RGD:1624291
G Nkx6-1 NK6 homeobox 1 JBrowse link 14 9,555,264 9,562,197 RGD:1624291
RGD:1600115
G Nkx6-2 NK6 homeobox 2 JBrowse link 1 211,922,389 211,923,929 RGD:1624291
RGD:1600115
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:1624291
RGD:1600115
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:1624291
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
RGD:1600115
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:1624291
RGD:1600115
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:1624291
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
RGD:1600115
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:1624291
RGD:1600115
spinal cord motor neuron cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hoxc10 homeo box C10 JBrowse link 7 144,577,578 144,582,802 RGD:1624291
RGD:1600115
G Hoxd10 homeo box D10 JBrowse link 3 61,614,133 61,617,342 RGD:1624291
RGD:1600115
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:1624291
RGD:1600115
G Isl2 ISL LIM homeobox 2 JBrowse link 8 60,117,565 60,122,716 RGD:1624291
RGD:1600115
G Lhx3 LIM homeobox 3 JBrowse link 3 3,653,861 3,662,509 RGD:1624291
RGD:1600115
G Mnx1 motor neuron and pancreas homeobox 1 JBrowse link 4 2,376,350 2,381,308 RGD:1624291
RGD:13792537
G Olig3 oligodendrocyte transcription factor 3 JBrowse link 1 14,797,766 14,799,835 RGD:1624291
RGD:1600115
ventral spinal cord interneuron specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dbx1 developing brain homeobox 1 JBrowse link 1 104,969,218 104,973,648 RGD:1624291
RGD:1600115
G Dmrt3 doublesex and mab-3 related transcription factor 3 JBrowse link 1 243,589,607 243,602,926 RGD:1624291
RGD:1600115
G Lhx3 LIM homeobox 3 JBrowse link 3 3,653,861 3,662,509 RGD:1624291
RGD:1600115
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:8553789
G Sox1 SRY-box transcription factor 1 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19317
    cellular process 17226
      cellular developmental process 4428
        cell fate specification 104
          neuron fate specification 37
            auditory receptor cell fate specification + 2
            photoreceptor cell fate specification + 0
            positive regulation of transcription from RNA polymerase II promoter involved in neuron fate specification 0
            spinal cord association neuron specification + 1
            spinal cord commissural neuron specification 0
            spinal cord motor neuron cell fate specification + 13
            ventral spinal cord interneuron specification + 12
Path 2
Term Annotations click to browse term
  biological_process 19317
    developmental process 6647
      anatomical structure development 6113
        multicellular organism development 5583
          system development 5101
            nervous system development 2597
              neurogenesis 1882
                generation of neurons 1747
                  neuron differentiation 1574
                    neuron fate commitment 78
                      neuron fate specification 37
                        auditory receptor cell fate specification + 2
                        photoreceptor cell fate specification + 0
                        positive regulation of transcription from RNA polymerase II promoter involved in neuron fate specification 0
                        spinal cord association neuron specification + 1
                        spinal cord commissural neuron specification 0
                        spinal cord motor neuron cell fate specification + 13
                        ventral spinal cord interneuron specification + 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.