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ONTOLOGY REPORT - ANNOTATIONS


Term:presynaptic active zone
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Accession:GO:0048786 term browser browse the term
Definition:A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
Synonyms:exact_synonym: pre-synaptic active zone;   presynaptic specialization
 narrow_synonym: pre-synaptic active zone component
 xref: NIF_Subcellular:sao792027222


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presynaptic active zone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADCY8 adenylate cyclase 8 JBrowse link 8 130,780,300 131,041,604 RGD:2290271
G ADORA1 adenosine A1 receptor JBrowse link 1 203,127,705 203,167,405 RGD:2290271
G ADORA2A adenosine A2a receptor JBrowse link 22 24,423,597 24,442,360 RGD:2290271
G APP amyloid beta precursor protein JBrowse link 21 25,880,550 26,171,128 RGD:2290271
G ARHGAP44 Rho GTPase activating protein 44 JBrowse link 17 12,789,498 12,991,644 RGD:2290271
G BRSK1 BR serine/threonine kinase 1 JBrowse link 19 55,283,997 55,312,562 RGD:2290271
G BSN bassoon presynaptic cytomatrix protein JBrowse link 3 49,554,477 49,671,549 RGD:2290271
G C1QBP complement C1q binding protein JBrowse link 17 5,432,777 5,439,155 RGD:2290271
G ERC2 ELKS/RAB6-interacting/CAST family member 2 JBrowse link 3 55,508,311 56,468,473 RGD:2290271
G FLOT1 flotillin 1 JBrowse link 6 30,727,709 30,742,851 RGD:2290271
G FZD3 frizzled class receptor 3 JBrowse link 8 28,494,205 28,574,268 RGD:2290271
G GAD1 glutamate decarboxylase 1 JBrowse link 2 170,813,210 170,861,151 RGD:2290271
G GPER1 G protein-coupled estrogen receptor 1 JBrowse link 7 1,086,807 1,093,815 RGD:2290271
G GRM7 glutamate metabotropic receptor 7 JBrowse link 3 6,861,115 7,743,038 RGD:2290271
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 JBrowse link 4 155,759,021 155,807,774 RGD:2290271
G NUFIP1 nuclear FMR1 interacting protein 1 JBrowse link 13 44,939,249 44,989,483 RGD:2290271
G PCLO piccolo presynaptic cytomatrix protein JBrowse link 7 82,754,012 83,164,161 RGD:2290271
G PHB2 prohibitin 2 JBrowse link 12 6,965,327 6,970,753 RGD:2290271
G PNISR PNN interacting serine and arginine rich protein JBrowse link 6 99,398,050 99,426,306 RGD:2290271
G PPFIA1 PTPRF interacting protein alpha 1 JBrowse link 11 70,270,687 70,385,312 RGD:2290271
G PPFIA2 PTPRF interacting protein alpha 2 JBrowse link 12 81,257,975 81,759,749 RGD:2290271
G PPFIA3 PTPRF interacting protein alpha 3 JBrowse link 19 49,119,389 49,151,030 RGD:2290271
G PPFIA4 PTPRF interacting protein alpha 4 JBrowse link 1 203,026,491 203,078,736 RGD:2290271
G RAB3A RAB3A, member RAS oncogene family JBrowse link 19 18,196,784 18,204,042 RGD:2290271
G RIMS1 regulating synaptic membrane exocytosis 1 JBrowse link 6 71,886,703 72,403,145 RGD:2290271
G RIMS2 regulating synaptic membrane exocytosis 2 JBrowse link 8 103,499,934 104,256,094 RGD:2290271
G RIMS3 regulating synaptic membrane exocytosis 3 JBrowse link 1 40,620,680 40,692,104 RGD:2290271
G RIMS4 regulating synaptic membrane exocytosis 4 JBrowse link 20 44,751,808 44,810,546 RGD:2290271
G SLC17A7 solute carrier family 17 member 7 JBrowse link 19 49,429,401 49,441,527 RGD:2290271
G SLC32A1 solute carrier family 32 member 1 JBrowse link 20 38,724,486 38,729,372 RGD:2290271
G SV2A synaptic vesicle glycoprotein 2A JBrowse link 1 149,903,318 149,917,844 RGD:2290271
G SYN1 synapsin I JBrowse link X 47,571,901 47,619,857 RGD:2290271
G SYP synaptophysin JBrowse link X 49,187,812 49,200,202 RGD:2290271
G UNC13A unc-13 homolog A JBrowse link 19 17,601,328 17,688,344 RGD:2290271
G UNC13B unc-13 homolog B JBrowse link 9 35,162,009 35,405,338 RGD:2290271
G UNC13C unc-13 homolog C JBrowse link 15 53,837,573 54,633,440 RGD:2290271
G VPS11 VPS11 core subunit of CORVET and HOPS complexes JBrowse link 11 119,067,752 119,081,978 RGD:2290271
anchored component of presynaptic active zone membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CPLX3 complexin 3 JBrowse link 15 74,826,627 74,831,802 RGD:2290271
G FLOT2 flotillin 2 JBrowse link 17 28,879,339 28,897,733 RGD:2290271
G NTNG1 netrin G1 JBrowse link 1 107,140,017 107,484,923 RGD:2290271
G NTNG2 netrin G2 JBrowse link 9 132,161,234 132,244,534 RGD:2290271
cytoskeleton of presynaptic active zone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BSN bassoon presynaptic cytomatrix protein JBrowse link 3 49,554,477 49,671,549 RGD:2290271
G PCLO piccolo presynaptic cytomatrix protein JBrowse link 7 82,754,012 83,164,161 RGD:2290271
G RIMS1 regulating synaptic membrane exocytosis 1 JBrowse link 6 71,886,703 72,403,145 RGD:2290271
G RIMS2 regulating synaptic membrane exocytosis 2 JBrowse link 8 103,499,934 104,256,094 RGD:2290271
G RIMS3 regulating synaptic membrane exocytosis 3 JBrowse link 1 40,620,680 40,692,104 RGD:2290271
G RIMS4 regulating synaptic membrane exocytosis 4 JBrowse link 20 44,751,808 44,810,546 RGD:2290271
extrinsic component of presynaptic active zone membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DGKI diacylglycerol kinase iota JBrowse link 7 137,381,037 137,846,864 RGD:2290271
integral component of presynaptic active zone membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATP2B1 ATPase plasma membrane Ca2+ transporting 1 JBrowse link 12 89,588,049 89,709,366 RGD:2290271
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 JBrowse link 1 203,626,787 203,744,081 RGD:2290271
G CACNA1D calcium voltage-gated channel subunit alpha1 D JBrowse link 3 53,494,611 53,813,733 RGD:2290271
G CANX calnexin JBrowse link 5 179,678,646 179,731,641 RGD:2290271
G CDH10 cadherin 10 JBrowse link 5 24,487,100 24,644,978 RGD:2290271
G CDH2 cadherin 2 JBrowse link 18 27,932,878 28,177,130 RGD:2290271
G GPM6A glycoprotein M6A JBrowse link 4 175,632,937 176,002,691 RGD:2290271
G LRFN3 leucine rich repeat and fibronectin type III domain containing 3 JBrowse link 19 35,936,374 35,946,624 RGD:2290271
G NECTIN1 nectin cell adhesion molecule 1 JBrowse link 11 119,638,098 119,729,200 RGD:2290271
G NPTN neuroplastin JBrowse link 15 73,560,014 73,633,389 RGD:2290271
G NRG1 neuregulin 1 JBrowse link 8 31,639,245 32,774,046 RGD:2290271
G NRXN1 neurexin 1 JBrowse link 2 49,918,503 51,032,536 RGD:2290271
G P2RX1 purinergic receptor P2X 1 JBrowse link 17 3,896,591 3,916,506 RGD:2290271
G P2RY1 purinergic receptor P2Y1 JBrowse link 3 152,835,131 152,841,439 RGD:2290271
G P2RY4 pyrimidinergic receptor P2Y4 JBrowse link X 70,258,166 70,259,804 RGD:2290271
G SYT11 synaptotagmin 11 JBrowse link 1 155,859,502 155,885,199 RGD:2290271
presynaptic active zone cytoplasmic component term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CTBP1 C-terminal binding protein 1 JBrowse link 4 1,211,444 1,253,919 RGD:2290271
G CTBP2 C-terminal binding protein 2 JBrowse link 10 124,984,317 125,161,039 RGD:2290271
G CTNNA2 catenin alpha 2 JBrowse link 2 79,505,054 80,648,868 RGD:2290271
G CTNNB1 catenin beta 1 JBrowse link 3 41,199,422 41,240,445 RGD:2290271
G CTNND1 catenin delta 1 JBrowse link 11 57,761,802 57,819,540 RGD:2290271
G ERC2 ELKS/RAB6-interacting/CAST family member 2 JBrowse link 3 55,508,311 56,468,473 RGD:2290271
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 JBrowse link 4 155,759,021 155,807,774 RGD:2290271
G PPFIA3 PTPRF interacting protein alpha 3 JBrowse link 19 49,119,389 49,151,030 RGD:2290271
G RIMS1 regulating synaptic membrane exocytosis 1 JBrowse link 6 71,886,703 72,403,145 RGD:2290271
G RIMS2 regulating synaptic membrane exocytosis 2 JBrowse link 8 103,499,934 104,256,094 RGD:2290271
G RIMS3 regulating synaptic membrane exocytosis 3 JBrowse link 1 40,620,680 40,692,104 RGD:2290271
G RIMS4 regulating synaptic membrane exocytosis 4 JBrowse link 20 44,751,808 44,810,546 RGD:2290271
G UNC13A unc-13 homolog A JBrowse link 19 17,601,328 17,688,344 RGD:2290271
G UNC13B unc-13 homolog B JBrowse link 9 35,162,009 35,405,338 RGD:2290271
G UNC13C unc-13 homolog C JBrowse link 15 53,837,573 54,633,440 RGD:2290271
presynaptic active zone membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APBA1 amyloid beta precursor protein binding family A member 1 JBrowse link 9 69,427,532 69,673,012 RGD:2290271
G CNTNAP1 contactin associated protein 1 JBrowse link 17 42,679,767 42,699,993 RGD:2290271
G STX11 syntaxin 11 JBrowse link 6 144,140,044 144,191,939 RGD:2290271
G STX19 syntaxin 19 JBrowse link 3 94,014,365 94,029,281 RGD:2290271
G STX1A syntaxin 1A JBrowse link 7 73,699,210 73,719,673 RGD:2290271
G STX1B syntaxin 1B JBrowse link 16 30,989,256 31,010,638 RGD:2290271
G STX2 syntaxin 2 JBrowse link 12 130,789,600 130,839,274 RGD:2290271
G STX3 syntaxin 3 JBrowse link 11 59,755,374 59,805,879 RGD:2290271
G STX4 syntaxin 4 JBrowse link 16 31,033,095 31,040,168 RGD:2290271
G STXBP1 syntaxin binding protein 1 JBrowse link 9 127,612,277 127,692,936 RGD:2290271
G SYT11 synaptotagmin 11 JBrowse link 1 155,859,502 155,885,199 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18749
    cellular anatomical entity 18561
      presynaptic active zone 73
        presynaptic active zone cytoplasmic component + 17
        presynaptic active zone dense projection 0
        presynaptic active zone membrane + 31
        presynaptic grid 0
Path 2
Term Annotations click to browse term
  cellular_component 18749
    cellular anatomical entity 18561
      synapse 1358
        presynapse 525
          presynaptic active zone 73
            presynaptic active zone cytoplasmic component + 17
            presynaptic active zone dense projection 0
            presynaptic active zone membrane + 31
            presynaptic grid 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.