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Term:arachidonate 15-lipoxygenase activity
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Accession:GO:0050473 term browser browse the term
Definition:Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.
Synonyms:exact_synonym: 15-lipoxygenase activity;   arachidonate omega(6) lipoxygenase activity;   arachidonate omega6 lipoxygenase activity;   arachidonate:oxygen 15-oxidoreductase activity;   linoleic acid omega6-lipoxygenase activity;   omega6 lipoxygenase activity
 xref: EC:;   MetaCyc:ARACHIDONATE-15-LIPOXYGENASE-RXN;   RHEA:16869;   reactome:R-HSA-2161951 "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2";   reactome:R-HSA-2162002 "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B";   reactome:R-HSA-9018907 "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3";   reactome:R-HSA-9020261 "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA";   reactome:R-HSA-9020262 "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA";   reactome:R-HSA-9020275 "ALOX15 oxidises DHA to 17(S)-Hp-DHA";   reactome:R-HSA-9020610 "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3";   reactome:R-HSA-9024872 "ALOX15 oxidises 17(S)-Hp-DHA to PDX";   reactome:R-HSA-9024881 "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA";   reactome:R-HSA-9025152 "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6";   reactome:R-HSA-9026003 "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3";   reactome:R-HSA-9027532 "PTGS2 dimer oxidises DHA to 13-HDHA";   reactome:R-HSA-9027607 "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3";   reactome:R-HSA-9027627 "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)";   reactome:R-HSA-9028255 "PTGS2 dimer oxidises EPA to PGH3"

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arachidonate 15-lipoxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:1600115
G Alox12e arachidonate 12-lipoxygenase, epidermal JBrowse link 10 56,927,676 56,935,141 RGD:13792537
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:70287
G Alox15b arachidonate 15-lipoxygenase, type B JBrowse link 10 55,773,748 55,783,489 RGD:8554649

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  molecular_function 19678
    catalytic activity 6023
      oxidoreductase activity 848
        dioxygenase activity 79
          oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 27
            arachidonate 15-lipoxygenase activity 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.