Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:homocysteine metabolic process
go back to main search page
Accession:GO:0050667 term browser browse the term
Definition:The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
Synonyms:exact_synonym: Hcy metabolic process;   Hcy metabolism;   homocysteine metabolism


show annotations for term's descendants           Sort by:
 
homocysteine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase TAS
IBA
ISO
IDA
PMID:21873635
MGI:MGI:1857139 (MGI:MGI:1888627|PMID:10953023), (MGI:MGI:1890086|PMID:10993757), (MGI:MGI:3039983|PMID:15131763), (MGI:MGI:3510570|PMID:15555590), (MGI:MGI:3611588|PMID:15916860), (MGI:MGI:3656462|PMID:15622513), (MGI:MGI:3663564|PMID:16226235), (MGI:MGI:3798351|PMID:18541157), (MGI:MGI:71081|PMID:7878023)
(PMID:19010420), (PMID:20031578), (PMID:23981774)
RGD PMID:7878023, PMID:10953023, PMID:10993757, PMID:15131763, PMID:15555590, PMID:15622513, PMID:15916860, PMID:16226235, PMID:18541157, PMID:19010420, PMID:20031578, PMID:23981774, PMID:12198128, PMID:21873635, PMID:9359866 MGI:MGI:1888627, MGI:MGI:1890086, MGI:MGI:3039983, MGI:MGI:3510570, MGI:MGI:3611588, MGI:MGI:3656462, MGI:MGI:3663564, MGI:MGI:3798351, MGI:MGI:71081, RGD:634704, RGD:13792537, RGD:1359024 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
JBrowse link
G Cth cystathionine gamma-lyase IDA RGD PMID:9359866 RGD:1359024 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Dpep1 dipeptidase 1 ISO
ISS
(PMID:20031578)
GO_REF:0000024
RGD
UniProt
PMID:20031578 GO_REF:0000024 NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
JBrowse link
G Mmut methylmalonyl-CoA mutase ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:23,323,934...23,352,144
Ensembl chr 9:23,323,936...23,352,668
JBrowse link
G Mthfr methylenetetrahydrofolate reductase IEP
ISO
(PMID:20031578) RGD PMID:20031578, PMID:18726220 RGD:2317121 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA
IMP
RGD PMID:11730351, PMID:21121936 RGD:1601423, RGD:7207080 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO
IBA
(MGI:MGI:3710265|PMID:17369066)
PMID:21873635
RGD PMID:17369066, PMID:21873635 MGI:MGI:3710265, RGD:13792537 NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015
JBrowse link
G Nox4 NADPH oxidase 4 ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
homocysteine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blmh bleomycin hydrolase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:63,197,367...63,240,447
Ensembl chr10:63,197,364...63,240,332
JBrowse link
G Cbs cystathionine beta synthase ISS
ISO
GO_REF:0000024
(PMID:18776696), (PMID:24416422)
UniProt
RGD
PMID:18776696, PMID:24416422 GO_REF:0000024 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO (PMID:11466310) RGD PMID:11466310 NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015
JBrowse link
positive regulation of homocysteine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase IMP RGD PMID:15779086 RGD:2289784 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
transsulfuration term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:16636197, PMID:21873635 RGD:1600624, RGD:13792537 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Cth cystathionine gamma-lyase TAS
IBA
IEA
ISO
PMID:21873635
GO_REF:0000002
(PMID:19428278)
InterPro
RGD
PMID:19428278, PMID:15347670, PMID:21873635 GO_REF:0000002, RGD:1600762, RGD:13792537 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G LOC103691744 cystathionine gamma-lyase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:264,747,068...264,765,112
Ensembl chr 2:264,746,485...264,765,085
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:17130129, PMID:21873635 RGD:9685559, RGD:13792537 NCBI chr 7:119,626,636...119,631,317
Ensembl chr 7:119,626,637...119,631,425
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO (MGI:MGI:5621260|PMID:23190757) RGD PMID:23190757 MGI:MGI:5621260 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Tst thiosulfate sulfurtransferase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:119,616,323...119,623,072
Ensembl chr 7:119,616,324...119,623,072
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      primary metabolic process 10901
        cellular amino acid metabolic process 274
          alpha-amino acid metabolic process 198
            homocysteine metabolic process 15
              homocysteine biosynthetic process + 0
              homocysteine catabolic process 3
              negative regulation of homocysteine metabolic process 0
              positive regulation of homocysteine metabolic process 1
              regulation of homocysteine metabolic process + 1
              transsulfuration 6
Path 2
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      cellular metabolic process 11064
        organic acid metabolic process 1089
          oxoacid metabolic process 1060
            carboxylic acid metabolic process 1004
              cellular amino acid metabolic process 274
                alpha-amino acid metabolic process 198
                  homocysteine metabolic process 15
                    homocysteine biosynthetic process + 0
                    homocysteine catabolic process 3
                    negative regulation of homocysteine metabolic process 0
                    positive regulation of homocysteine metabolic process 1
                    regulation of homocysteine metabolic process + 1
                    transsulfuration 6
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.