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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-1 secretion
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Accession:GO:0050701 term browser browse the term
Definition:The regulated release of interleukin-1 from a cell. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response.
Synonyms:exact_synonym: IL-1 secretion


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interleukin-1 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:1624291
RGD:1600115
interleukin-1 alpha secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G S100a13 S100 calcium binding protein A13 JBrowse link 2 189,906,022 189,912,516 RGD:1624291
RGD:1600115
interleukin-1 beta secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:1624291
RGD:1600115
G Aim2 absent in melanoma 2 JBrowse link 13 91,919,834 91,963,080 RGD:1624291
RGD:1600115
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:1624291
RGD:1600115
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
RGD:1600115
G Gbp5 guanylate binding protein 5 JBrowse link 2 248,178,441 248,196,873 RGD:1624291
RGD:1600115
G Nlrc4 NLR family, CARD domain containing 4 JBrowse link 6 22,167,874 22,194,755 RGD:1624291
RGD:13792537
RGD:1600115
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1600115
RGD:1624291
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:1624291
G Tmem106a transmembrane protein 106A JBrowse link 10 89,484,269 89,493,288 RGD:1600115
RGD:1624291
negative regulation of interleukin-1 alpha secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:1624291
RGD:1600115
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:10043380
negative regulation of interleukin-1 beta secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
RGD:1600115
G Cptp ceramide-1-phosphate transfer protein JBrowse link 5 173,314,219 173,318,384 RGD:1600115
RGD:1624291
G Nlrp1b NLR family, pyrin domain containing 1B JBrowse link 10 57,755,957 57,847,867 RGD:1624291
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:1624291
RGD:1600115
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
RGD:1600115
G Serpinb1a serpin family B member 1A JBrowse link 17 32,903,089 32,911,498 RGD:1600115
RGD:1624291
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1600115
RGD:1624291
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1624291
RGD:1600115
negative regulation of interleukin-1 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
RGD:1600115
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
positive regulation of interleukin-1 alpha secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:1624291
RGD:1600115
G Nlrp10 NLR family, pyrin domain containing 10 JBrowse link 1 173,521,412 173,528,969 RGD:1624291
RGD:1600115
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Panx1 Pannexin 1 JBrowse link 8 13,567,185 13,606,040 RGD:1624291
RGD:1600115
positive regulation of interleukin-1 beta secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aim2 absent in melanoma 2 JBrowse link 13 91,919,834 91,963,080 RGD:1624291
RGD:13792537
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:2315918
RGD:1624291
RGD:1600115
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:1624291
RGD:1600115
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:1624291
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:1624291
RGD:1600115
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:1598562
G Fzd5 frizzled class receptor 5 JBrowse link 9 71,443,784 71,445,541 RGD:1600115
RGD:1624291
G Gsdmd gasdermin D JBrowse link 7 116,889,147 116,894,134 RGD:1624291
RGD:1600115
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:1624291
RGD:1600115
G Hmg1l1 high-mobility group (nonhistone chromosomal) protein 1-like 1 JBrowse link 19 59,984,234 59,985,494 RGD:13792537
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
RGD:13792537
G Hmgb4 high-mobility group box 4 JBrowse link 5 146,445,545 146,446,227 RGD:13792537
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:1624291
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
RGD:1600115
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Lilra5 leukocyte immunoglobulin like receptor A5 JBrowse link 1 73,655,767 73,682,232 RGD:1624291
G LOC108349258 high mobility group protein B4-like JBrowse link X 142,344,626 142,345,439 RGD:13792537
G LOC108350839 high mobility group protein B1-like JBrowse link 4 92,431,517 92,432,354 RGD:13792537
G LOC681067 similar to RIKEN cDNA 1700001F22 JBrowse link X 132,424,185 132,424,955 RGD:13792537
G LOC691030 similar to RIKEN cDNA 1700001F22 JBrowse link X 130,794,079 130,794,824 RGD:13792537
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:1600115
RGD:1624291
G Nlrp1a NLR family, pyrin domain containing 1A JBrowse link 10 57,692,474 57,747,608 RGD:1624291
RGD:13792537
G Nlrp1b NLR family, pyrin domain containing 1B JBrowse link 10 57,755,957 57,847,867 RGD:1624291
G Nlrp2 NLR family pyrin domain containing 2 JBrowse link 1 73,082,648 73,121,118 RGD:1624291
RGD:13792537
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:13792537
RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
RGD:1600115
G Orm1 orosomucoid 1 JBrowse link 5 79,179,668 79,182,820 RGD:1624291
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1642715
RGD:1600115
RGD:1624291
G Panx1 Pannexin 1 JBrowse link 8 13,567,185 13,606,040 RGD:1624291
RGD:1600115
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
RGD:1600115
G RGD1560585 similar to RIKEN cDNA 1700001F22 JBrowse link X 144,001,166 144,001,891 RGD:13792537
G RGD1561558 similar to RIKEN cDNA 1700001F22 JBrowse link X 158,261,123 158,261,953 RGD:13792537
G RGD1566225 similar to RIKEN cDNA 1700001F22 JBrowse link X 137,197,195 137,197,990 RGD:13792537
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
RGD:1600115
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
G Tlr8 toll-like receptor 8 JBrowse link X 28,539,158 28,562,803 RGD:1624291
RGD:1600115
G Trim16 tripartite motif-containing 16 JBrowse link 10 49,231,660 49,254,653 RGD:1624291
G Usp50 ubiquitin specific peptidase 50 JBrowse link 3 119,225,055 119,247,442 RGD:1624291
RGD:1600115
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
positive regulation of interleukin-1 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmg1l1 high-mobility group (nonhistone chromosomal) protein 1-like 1 JBrowse link 19 59,984,234 59,985,494 RGD:13792537
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
RGD:13792537
G Hmgb4 high-mobility group box 4 JBrowse link 5 146,445,545 146,446,227 RGD:13792537
G LOC108349258 high mobility group protein B4-like JBrowse link X 142,344,626 142,345,439 RGD:13792537
G LOC108350839 high mobility group protein B1-like JBrowse link 4 92,431,517 92,432,354 RGD:13792537
G LOC681067 similar to RIKEN cDNA 1700001F22 JBrowse link X 132,424,185 132,424,955 RGD:13792537
G LOC691030 similar to RIKEN cDNA 1700001F22 JBrowse link X 130,794,079 130,794,824 RGD:13792537
G Orm1 orosomucoid 1 JBrowse link 5 79,179,668 79,182,820 RGD:1624291
G Panx1 Pannexin 1 JBrowse link 8 13,567,185 13,606,040 RGD:1600115
G Panx2 pannexin 2 JBrowse link 7 130,042,948 130,053,034 RGD:1600115
G Panx3 pannexin 3 JBrowse link 8 40,126,379 40,137,390 RGD:1600115
G RGD1560585 similar to RIKEN cDNA 1700001F22 JBrowse link X 144,001,166 144,001,891 RGD:13792537
G RGD1561558 similar to RIKEN cDNA 1700001F22 JBrowse link X 158,261,123 158,261,953 RGD:13792537
G RGD1566225 similar to RIKEN cDNA 1700001F22 JBrowse link X 137,197,195 137,197,990 RGD:13792537
regulation of interleukin-1 beta secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg2 arginase 2 JBrowse link 6 102,311,097 102,338,406 RGD:1600115
RGD:1624291
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:1624291
RGD:1600115
G Foxp1 forkhead box P1 JBrowse link 4 131,362,178 131,963,466 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    multicellular organismal process 8629
      cytokine production 781
        interleukin-1 production 113
          interleukin-1 secretion 64
            interleukin-1 alpha secretion + 7
            interleukin-1 beta secretion + 56
            negative regulation of interleukin-1 secretion + 12
            positive regulation of interleukin-1 secretion + 43
            regulation of interleukin-1 secretion + 56
Path 2
Term Annotations click to browse term
  biological_process 18166
    localization 6061
      establishment of localization 4655
        transport 4517
          nitrogen compound transport 2185
            amide transport 1867
              peptide transport 1834
                peptide secretion 687
                  protein secretion 634
                    cytokine secretion 260
                      interleukin-1 secretion 64
                        interleukin-1 alpha secretion + 7
                        interleukin-1 beta secretion + 56
                        negative regulation of interleukin-1 secretion + 12
                        positive regulation of interleukin-1 secretion + 43
                        regulation of interleukin-1 secretion + 56
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.