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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of interleukin-1 secretion
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Accession:GO:0050704 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell.


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negative regulation of interleukin-1 alpha secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:1624291
RGD:1600115
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:10043380
negative regulation of interleukin-1 beta secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
RGD:1600115
G Cptp ceramide-1-phosphate transfer protein JBrowse link 5 173,314,219 173,318,384 RGD:1600115
RGD:1624291
G Nlrp1b NLR family, pyrin domain containing 1B JBrowse link 10 57,755,957 57,847,867 RGD:1624291
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:1624291
RGD:1600115
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
RGD:1600115
G Serpinb1a serpin family B member 1A JBrowse link 17 32,903,089 32,911,498 RGD:1600115
RGD:1624291
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1600115
RGD:1624291
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1624291
RGD:1600115
negative regulation of interleukin-1 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
RGD:1600115
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
positive regulation of interleukin-1 alpha secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:1624291
RGD:1600115
G Nlrp10 NLR family, pyrin domain containing 10 JBrowse link 1 173,521,412 173,528,969 RGD:1624291
RGD:1600115
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Panx1 Pannexin 1 JBrowse link 8 13,567,185 13,606,040 RGD:1624291
RGD:1600115
positive regulation of interleukin-1 beta secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07009373.1 RGD:13792537
G AABR07019870.1 RGD:13792537
G AABR07025074.1 RGD:13792537
G AABR07030543.1 RGD:13792537
G AABR07040430.1 RGD:13792537
G AABR07040480.1 RGD:13792537
G AABR07041586.2 RGD:13792537
G AABR07060165.1 RGD:13792537
G AABR07060287.1 RGD:13792537
G AABR07067274.1 RGD:13792537
G AC094217.2 RGD:13792537
G Aim2 absent in melanoma 2 JBrowse link 13 91,919,834 91,963,080 RGD:1624291
RGD:13792537
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:2315918
RGD:1624291
RGD:1600115
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:1624291
RGD:1600115
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:1624291
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:1624291
RGD:1600115
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:1598562
G Fzd5 frizzled class receptor 5 JBrowse link 9 71,443,784 71,445,541 RGD:1600115
RGD:1624291
G Gsdmd gasdermin D JBrowse link 7 116,889,147 116,894,134 RGD:1624291
RGD:1600115
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:1624291
RGD:1600115
G Hmg1l1 high-mobility group (nonhistone chromosomal) protein 1-like 1 JBrowse link 19 59,984,234 59,985,494 RGD:13792537
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
RGD:13792537
G Hmgb4 high-mobility group box 4 JBrowse link 5 146,445,545 146,446,227 RGD:13792537
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:1624291
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
RGD:1600115
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Lilra5 leukocyte immunoglobulin like receptor A5 JBrowse link 1 73,655,767 73,682,232 RGD:1624291
G LOC108349258 high mobility group protein B4-like JBrowse link X 142,344,626 142,345,439 RGD:13792537
G LOC108350839 high mobility group protein B1-like JBrowse link 4 92,431,517 92,432,354 RGD:13792537
G LOC681067 similar to RIKEN cDNA 1700001F22 JBrowse link X 132,424,185 132,424,955 RGD:13792537
G LOC691030 similar to RIKEN cDNA 1700001F22 JBrowse link X 130,794,079 130,794,824 RGD:13792537
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:1600115
RGD:1624291
G Nlrp1a NLR family, pyrin domain containing 1A JBrowse link 10 57,692,474 57,747,608 RGD:1624291
RGD:13792537
G Nlrp1b NLR family, pyrin domain containing 1B JBrowse link 10 57,755,957 57,847,867 RGD:1624291
G Nlrp2 NLR family pyrin domain containing 2 JBrowse link 1 73,082,648 73,121,118 RGD:1624291
RGD:13792537
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:13792537
RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
RGD:1600115
G Orm1 orosomucoid 1 JBrowse link 5 79,179,668 79,182,820 RGD:1624291
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1642715
RGD:1600115
RGD:1624291
G Panx1 Pannexin 1 JBrowse link 8 13,567,185 13,606,040 RGD:1624291
RGD:1600115
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
RGD:1600115
G RGD1560585 similar to RIKEN cDNA 1700001F22 JBrowse link X 144,001,166 144,001,891 RGD:13792537
G RGD1561558 similar to RIKEN cDNA 1700001F22 JBrowse link X 158,261,123 158,261,953 RGD:13792537
G RGD1566225 similar to RIKEN cDNA 1700001F22 JBrowse link X 137,197,195 137,197,990 RGD:13792537
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
RGD:1600115
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
G Tlr8 toll-like receptor 8 JBrowse link X 28,539,158 28,562,803 RGD:1624291
RGD:1600115
G Trim16 tripartite motif-containing 16 JBrowse link 10 49,231,660 49,254,653 RGD:1624291
G Usp50 ubiquitin specific peptidase 50 JBrowse link 3 119,225,055 119,247,442 RGD:1624291
RGD:1600115
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
positive regulation of interleukin-1 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07009373.1 RGD:13792537
G AABR07019870.1 RGD:13792537
G AABR07025074.1 RGD:13792537
G AABR07030543.1 RGD:13792537
G AABR07040430.1 RGD:13792537
G AABR07040480.1 RGD:13792537
G AABR07041586.2 RGD:13792537
G AABR07060165.1 RGD:13792537
G AABR07060287.1 RGD:13792537
G AABR07067274.1 RGD:13792537
G AC094217.2 RGD:13792537
G Hmg1l1 high-mobility group (nonhistone chromosomal) protein 1-like 1 JBrowse link 19 59,984,234 59,985,494 RGD:13792537
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
RGD:13792537
G Hmgb4 high-mobility group box 4 JBrowse link 5 146,445,545 146,446,227 RGD:13792537
G LOC108349258 high mobility group protein B4-like JBrowse link X 142,344,626 142,345,439 RGD:13792537
G LOC108350839 high mobility group protein B1-like JBrowse link 4 92,431,517 92,432,354 RGD:13792537
G LOC681067 similar to RIKEN cDNA 1700001F22 JBrowse link X 132,424,185 132,424,955 RGD:13792537
G LOC691030 similar to RIKEN cDNA 1700001F22 JBrowse link X 130,794,079 130,794,824 RGD:13792537
G Orm1 orosomucoid 1 JBrowse link 5 79,179,668 79,182,820 RGD:1624291
G Panx1 Pannexin 1 JBrowse link 8 13,567,185 13,606,040 RGD:1600115
G Panx2 pannexin 2 JBrowse link 7 130,042,948 130,053,034 RGD:1600115
G Panx3 pannexin 3 JBrowse link 8 40,126,379 40,137,390 RGD:1600115
G RGD1560585 similar to RIKEN cDNA 1700001F22 JBrowse link X 144,001,166 144,001,891 RGD:13792537
G RGD1561558 similar to RIKEN cDNA 1700001F22 JBrowse link X 158,261,123 158,261,953 RGD:13792537
G RGD1566225 similar to RIKEN cDNA 1700001F22 JBrowse link X 137,197,195 137,197,990 RGD:13792537
regulation of interleukin-1 beta secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg2 arginase 2 JBrowse link 6 102,311,097 102,338,406 RGD:1600115
RGD:1624291
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:1624291
RGD:1600115
G Foxp1 forkhead box P1 JBrowse link 4 131,362,178 131,963,466 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19245
    multicellular organismal process 8749
      cytokine production 797
        regulation of cytokine production 718
          regulation of interleukin-1 production 110
            regulation of interleukin-1 secretion 67
              negative regulation of interleukin-1 secretion + 12
              positive regulation of interleukin-1 secretion + 54
              regulation of interleukin-1 alpha secretion + 6
              regulation of interleukin-1 beta secretion + 60
Path 2
Term Annotations click to browse term
  biological_process 19245
    localization 6273
      establishment of localization 4844
        transport 4705
          nitrogen compound transport 2235
            amide transport 1913
              peptide transport 1880
                regulation of peptide transport 838
                  regulation of protein transport 790
                    regulation of protein secretion 533
                      regulation of cytokine secretion 242
                        regulation of interleukin-1 secretion 67
                          negative regulation of interleukin-1 secretion + 12
                          positive regulation of interleukin-1 secretion + 54
                          regulation of interleukin-1 alpha secretion + 6
                          regulation of interleukin-1 beta secretion + 60
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.