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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cytokine secretion
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Accession:GO:0050710 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
Synonyms:exact_synonym: down regulation of cytokine secretion;   downregulation of cytokine secretion
 narrow_synonym: inhibition of cytokine secretion


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negative regulation of cytokine secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Btn1a1 butyrophilin, subfamily 1, member A1 JBrowse link 17 43,899,155 43,909,042 RGD:1624291
G Btn2a2 butyrophilin, subfamily 2, member A2 JBrowse link 17 43,867,243 43,878,734 RGD:1624291
RGD:1600115
G Cidea cell death-inducing DFFA-like effector a JBrowse link 18 63,082,861 63,108,450 RGD:1624291
RGD:1600115
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:4892003
G Ffar4 free fatty acid receptor 4 JBrowse link 1 256,786,124 256,804,156 RGD:1624291
RGD:1600115
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
RGD:1600115
G Hdac9 histone deacetylase 9 JBrowse link 6 53,487,367 54,358,694 RGD:1600115
RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:2306938
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 JBrowse link 3 101,051,960 101,152,119 RGD:1624291
RGD:1600115
G Lrrc32 leucine rich repeat containing 32 JBrowse link 1 163,443,972 163,457,426 RGD:1624291
RGD:1600115
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
G Ppp1r11 protein phosphatase 1, regulatory (inhibitor) subunit 11 JBrowse link 20 2,094,931 2,098,438 RGD:1624291
RGD:1600115
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:1600115
RGD:1624291
G Rgcc regulator of cell cycle JBrowse link 15 61,551,861 61,564,695 RGD:1624291
RGD:1600115
G Srgn serglycin JBrowse link 20 32,120,317 32,158,071 RGD:1624291
RGD:1600115
G Syt11 synaptotagmin 11 JBrowse link 2 188,112,301 188,138,180 RGD:1600115
RGD:1624291
G Tnfrsf4 TNF receptor superfamily member 4 JBrowse link 5 173,447,784 173,450,474 RGD:1624291
RGD:13792537
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1624291
RGD:1600115
negative regulation of chemokine secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
RGD:1600115
negative regulation of cytokine secretion involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Angpt1 angiopoietin 1 JBrowse link 7 81,338,327 81,592,459 RGD:1624291
RGD:1600115
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
RGD:1600115
G Apoa2 apolipoprotein A2 JBrowse link 13 89,596,872 89,598,805 RGD:1624291
RGD:1600115
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1624291
RGD:1600115
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
negative regulation of endothelin secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:10043380
negative regulation of interferon-gamma secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il36rn interleukin 36 receptor antagonist JBrowse link 3 1,385,256 1,392,275 RGD:1624291
RGD:1600115
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:1600115
RGD:1624291
G Slamf1 signaling lymphocytic activation molecule family member 1 JBrowse link 13 90,184,545 90,219,170 RGD:1624291
RGD:1600115
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1624291
RGD:1600115
negative regulation of interleukin-1 alpha secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:1624291
RGD:1600115
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:10043380
negative regulation of interleukin-1 beta secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
RGD:1600115
G Cptp ceramide-1-phosphate transfer protein JBrowse link 5 173,314,219 173,318,384 RGD:1600115
RGD:1624291
G Nlrp1b NLR family, pyrin domain containing 1B JBrowse link 10 57,755,957 57,847,867 RGD:1624291
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:1624291
RGD:1600115
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
RGD:1600115
G Serpinb1a serpin family B member 1A JBrowse link 17 32,903,089 32,911,498 RGD:1600115
RGD:1624291
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1600115
RGD:1624291
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1624291
RGD:1600115
negative regulation of interleukin-1 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
RGD:1600115
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
negative regulation of interleukin-10 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd84 CD84 molecule JBrowse link 13 90,241,369 90,283,625 RGD:1624291
G Tnfrsf21 TNF receptor superfamily member 21 JBrowse link 9 20,546,159 20,621,051 RGD:1624291
RGD:13792537
RGD:1600115
G Tnfrsf9 TNF receptor superfamily member 9 JBrowse link 5 168,009,245 168,035,813 RGD:1624291
negative regulation of interleukin-12 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lilra5 leukocyte immunoglobulin like receptor A5 JBrowse link 1 73,655,767 73,682,232 RGD:1624291
G Tlr8 toll-like receptor 8 JBrowse link X 28,539,158 28,562,803 RGD:1624291
RGD:1600115
G Tnfrsf9 TNF receptor superfamily member 9 JBrowse link 5 168,009,245 168,035,813 RGD:1624291
negative regulation of interleukin-13 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg2 arginase 2 JBrowse link 6 102,311,097 102,338,406 RGD:1600115
RGD:1624291
G Lilra5 leukocyte immunoglobulin like receptor A5 JBrowse link 1 73,655,767 73,682,232 RGD:1624291
G Tnfrsf21 TNF receptor superfamily member 21 JBrowse link 9 20,546,159 20,621,051 RGD:1624291
RGD:13792537
RGD:1600115
negative regulation of interleukin-17 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg2 arginase 2 JBrowse link 6 102,311,097 102,338,406 RGD:1600115
RGD:1624291
G Il27ra interleukin 27 receptor subunit alpha JBrowse link 19 25,151,835 25,163,995 RGD:1600115
RGD:1624291
G Otud5 OTU deubiquitinase 5 JBrowse link X 15,471,212 15,504,372 RGD:1624291
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:1624291
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 JBrowse link 7
7
76,789,110
76,839,661
76,835,517
76,907,441
RGD:1624291
negative regulation of interleukin-2 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd34 CD34 molecule JBrowse link 13 113,691,842 113,711,259 RGD:1624291
RGD:1600115
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:1624291
RGD:1600115
G Gbp1 guanylate binding protein 1 JBrowse link 2 248,343,334 248,423,402 RGD:1624291
G Trim27 tripartite motif-containing 27 JBrowse link 17 45,613,863 45,626,212 RGD:1624291
RGD:1600115
negative regulation of interleukin-5 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnfrsf21 TNF receptor superfamily member 21 JBrowse link 9 20,546,159 20,621,051 RGD:1624291
RGD:13792537
RGD:1600115
negative regulation of interleukin-6 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bank1 B-cell scaffold protein with ankyrin repeats 1 JBrowse link 2 241,273,763 241,545,527 RGD:1624291
RGD:1600115
G C1qtnf3 C1q and TNF related 3 JBrowse link 2 60,920,160 60,942,586 RGD:1624291
G C5ar2 complement component 5a receptor 2 JBrowse link 1 78,165,155 78,183,426 RGD:1624291
RGD:1600115
G Cd200 Cd200 molecule JBrowse link 11 60,371,617 60,398,450 RGD:13792521
G Cd200r1 CD200 receptor 1 JBrowse link 11 60,848,161 60,882,470 RGD:13792521
G Cd84 CD84 molecule JBrowse link 13 90,241,369 90,283,625 RGD:1624291
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Il27ra interleukin 27 receptor subunit alpha JBrowse link 19 25,151,835 25,163,995 RGD:1600115
RGD:1624291
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:1600115
G Rabgef1 RAB guanine nucleotide exchange factor 1 JBrowse link 12 29,960,132 30,004,727 RGD:1624291
RGD:1600115
G Syt11 synaptotagmin 11 JBrowse link 2 188,112,301 188,138,180 RGD:1624291
RGD:1600115
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1624291
RGD:1600115
negative regulation of interleukin-8 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:1624291
RGD:13792537
G Anxa4 annexin A4 JBrowse link 4 118,538,775 118,595,591 RGD:1624291
RGD:1600115
G Mapkbp1 mitogen activated protein kinase binding protein 1 JBrowse link 3 111,767,126 111,817,103 RGD:1624291
RGD:1600115
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:1600115
G Ssc5d scavenger receptor cysteine rich family member with 5 domains JBrowse link 1 72,443,750 72,462,293 RGD:1624291
RGD:1600115
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:1624291
RGD:1600115
G Tmsb4x thymosin beta 4, X-linked JBrowse link X 28,593,405 28,617,267 RGD:1624291
negative regulation of transforming growth factor-beta secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fbln1 fibulin 1 JBrowse link 7 126,096,793 126,176,468 RGD:1624291
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:1600115
RGD:1624291
negative regulation of tumor necrosis factor secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg2 arginase 2 JBrowse link 6 102,311,097 102,338,406 RGD:1600115
RGD:1624291
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:1600115
RGD:1624291
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:12905041
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:12907501
G Il27ra interleukin 27 receptor subunit alpha JBrowse link 19 25,151,835 25,163,995 RGD:1600115
RGD:1624291
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:1600115
RGD:1624291
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:10043380
G Syt11 synaptotagmin 11 JBrowse link 2 188,112,301 188,138,180 RGD:1624291
RGD:1600115
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:1624291
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19245
    multicellular organismal process 8749
      negative regulation of multicellular organismal process 1354
        negative regulation of cytokine production 270
          negative regulation of cytokine secretion 68
            negative regulation of chemokine secretion + 1
            negative regulation of cytokine secretion involved in immune response 5
            negative regulation of endothelin secretion 1
            negative regulation of glial cell-derived neurotrophic factor secretion 0
            negative regulation of interferon-alpha secretion 0
            negative regulation of interferon-beta secretion 0
            negative regulation of interferon-gamma secretion 5
            negative regulation of interleukin-1 secretion + 12
            negative regulation of interleukin-10 secretion 3
            negative regulation of interleukin-12 secretion 3
            negative regulation of interleukin-13 secretion 3
            negative regulation of interleukin-17 secretion 5
            negative regulation of interleukin-2 secretion 4
            negative regulation of interleukin-5 secretion 1
            negative regulation of interleukin-6 secretion 12
            negative regulation of interleukin-7 secretion 0
            negative regulation of interleukin-8 secretion 7
            negative regulation of transforming growth factor-beta secretion 2
            negative regulation of tumor necrosis factor secretion 10
Path 2
Term Annotations click to browse term
  biological_process 19245
    localization 6273
      establishment of localization 4844
        transport 4705
          nitrogen compound transport 2235
            amide transport 1913
              peptide transport 1880
                peptide secretion 704
                  protein secretion 651
                    cytokine secretion 272
                      regulation of cytokine secretion 242
                        negative regulation of cytokine secretion 68
                          negative regulation of chemokine secretion + 1
                          negative regulation of cytokine secretion involved in immune response 5
                          negative regulation of endothelin secretion 1
                          negative regulation of glial cell-derived neurotrophic factor secretion 0
                          negative regulation of interferon-alpha secretion 0
                          negative regulation of interferon-beta secretion 0
                          negative regulation of interferon-gamma secretion 5
                          negative regulation of interleukin-1 secretion + 12
                          negative regulation of interleukin-10 secretion 3
                          negative regulation of interleukin-12 secretion 3
                          negative regulation of interleukin-13 secretion 3
                          negative regulation of interleukin-17 secretion 5
                          negative regulation of interleukin-2 secretion 4
                          negative regulation of interleukin-5 secretion 1
                          negative regulation of interleukin-6 secretion 12
                          negative regulation of interleukin-7 secretion 0
                          negative regulation of interleukin-8 secretion 7
                          negative regulation of transforming growth factor-beta secretion 2
                          negative regulation of tumor necrosis factor secretion 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.