ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of synaptic transmission
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Accession:GO:0050805 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
Synonyms:exact_synonym: down regulation of synaptic transmission;   downregulation of synaptic transmission
 narrow_synonym: inhibition of synaptic transmission


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negative regulation of synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1624291
RGD:1600115
G Adnp activity-dependent neuroprotector homeobox JBrowse link 3 164,937,188 164,964,819 RGD:2312778
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:1599456
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 JBrowse link 20 1,955,344 1,984,907 RGD:2315497
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:625670
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:625670
G Grm4 glutamate metabotropic receptor 4 JBrowse link 20 6,745,682 6,791,521 RGD:8554134
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1600115
RGD:1624291
G Npy2r neuropeptide Y receptor Y2 JBrowse link 2 181,528,949 181,538,145 RGD:1642503
G Pcdh17 protocadherin 17 JBrowse link 15 67,555,835 67,647,990 RGD:1624291
RGD:1600115
G Rapgef4 Rap guanine nucleotide exchange factor 4 JBrowse link 3 58,632,338 58,925,127 RGD:2314692
G Tnr tenascin R JBrowse link 13 77,602,249 77,678,385 RGD:1624291
RGD:1600115
long-term synaptic depression term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd6 abhydrolase domain containing 6 JBrowse link 15 18,647,903 18,695,133 RGD:1624291
RGD:1600115
G Arf1 ADP-ribosylation factor 1 JBrowse link 10 45,562,700 45,579,214 RGD:8553918
G Cd38 CD38 molecule JBrowse link 14 71,714,768 71,754,990 RGD:2307271
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:1624291
RGD:1600115
G Drd5 dopamine receptor D5 JBrowse link 14 77,220,579 77,222,006 RGD:1624291
RGD:1600115
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:1624291
RGD:1600115
G Grid2ip Grid2 interacting protein JBrowse link 12 13,221,334 13,257,365 RGD:1624291
RGD:1600115
G Mgll monoglyceride lipase JBrowse link 4 120,671,436 120,773,458 RGD:1624291
G Pick1 protein interacting with PRKCA 1 JBrowse link 7 120,465,472 120,484,824 RGD:8554238
G Plk2 polo-like kinase 2 JBrowse link 2 41,911,143 41,916,901 RGD:7241548
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:4144068
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:10041066
G Shank2 SH3 and multiple ankyrin repeat domains 2 JBrowse link 1 217,149,156 217,593,950 RGD:1624291
RGD:1600115
G Shank3 SH3 and multiple ankyrin repeat domains 3 JBrowse link 7 130,474,278 130,534,679 RGD:1624291
RGD:1600115
G Slc24a1 solute carrier family 24 member 1 JBrowse link 8 70,409,683 70,438,352 RGD:13792537
G Slc24a2 solute carrier family 24 member 2 JBrowse link 5 105,336,287 105,579,959 RGD:1624291
RGD:13792537
G Sorcs2 sortilin-related VPS10 domain containing receptor 2 JBrowse link 14 79,538,911 79,912,333 RGD:1600115
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:1624291
RGD:1600115
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:1624291
RGD:1600115
negative regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htr6 5-hydroxytryptamine receptor 6 JBrowse link 5 157,501,202 157,518,870 RGD:2317005
negative regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:1624291
RGD:1600115
negative regulation of excitatory postsynaptic potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbln1 cerebellin 1 precursor JBrowse link 19 20,607,507 20,611,316 RGD:1624291
RGD:1600115
G Celf4 CUGBP, Elav-like family member 4 JBrowse link 18 17,689,090 18,079,835 RGD:1624291
G Eif4a3 eukaryotic translation initiation factor 4A3 JBrowse link 10 108,415,201 108,425,195 RGD:10044262
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:1600115
G Mtmr2 myotubularin related protein 2 JBrowse link 8 12,283,471 12,334,014 RGD:8553482
G Nlgn3 neuroligin 3 JBrowse link X 71,199,390 71,227,460 RGD:1624291
RGD:1600115
G Npy2r neuropeptide Y receptor Y2 JBrowse link 2 181,528,949 181,538,145 RGD:1642608
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:10413844
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
RGD:1600115
G S1pr2 sphingosine-1-phosphate receptor 2 JBrowse link 8 21,984,914 21,995,806 RGD:1624291
RGD:1600115
negative regulation of long-term synaptic depression term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora1 adenosine A1 receptor JBrowse link 13 51,042,111 51,076,913 RGD:1624291
RGD:1600115
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1600115
RGD:1624291
G Fmr1 fragile X mental retardation 1 JBrowse link X 154,684,924 154,722,369 RGD:1624291
RGD:1600115
negative regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Syne1 spectrin repeat containing nuclear envelope protein 1 JBrowse link 1
1
41,608,287
41,844,840
41,763,591
42,086,662
RGD:13209020
negative regulation of neurotransmitter secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asic1 acid sensing ion channel subunit 1 JBrowse link 7 141,324,714 141,354,937 RGD:1624291
RGD:1600115
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:1624291
RGD:1600115
G Pnkd PNKD metallo-beta-lactamase domain containing JBrowse link 9 81,566,074 81,634,531 RGD:1624291
RGD:1600115
G Slc30a1 solute carrier family 30 member 1 JBrowse link 13 110,677,810 110,681,683 RGD:8554228
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:11535116
negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A JBrowse link 4 29,976,485 30,247,371 RGD:10002752
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
negative regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 JBrowse link 5 139,625,783 139,677,300 RGD:1600308
G Pmch pro-melanin-concentrating hormone JBrowse link 7 28,655,206 28,656,522 RGD:1642493
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:2300272
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:4889470
negative regulation of synaptic transmission, GABAergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora1 adenosine A1 receptor JBrowse link 13 51,042,111 51,076,913 RGD:1625273
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:1624291
G Cnr2 cannabinoid receptor 2 JBrowse link 5 154,242,010 154,268,126 RGD:2316192
G Grik1 glutamate ionotropic receptor kainate type subunit 1 JBrowse link 11 27,811,954 28,213,940 RGD:1642497
G Htr1b 5-hydroxytryptamine receptor 1B JBrowse link 8 89,113,984 89,130,830 RGD:1626455
G Npy5r neuropeptide Y receptor Y5 JBrowse link 16 24,796,685 24,805,730 RGD:1625505
G Slc6a1 solute carrier family 6 member 1 JBrowse link 4 146,258,842 146,292,176 RGD:1643193
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:1624291
RGD:1600115
negative regulation of synaptic transmission, glutamatergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora1 adenosine A1 receptor JBrowse link 13 51,042,111 51,076,913 RGD:1625231
G Atad1 ATPase family, AAA domain containing 1 JBrowse link 1 251,234,702 251,386,996 RGD:1624291
RGD:1600115
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1624291
RGD:1600115
G Grik1 glutamate ionotropic receptor kainate type subunit 1 JBrowse link 11 27,811,954 28,213,940 RGD:1642466
RGD:1624291
G Grik2 glutamate ionotropic receptor kainate type subunit 2 JBrowse link 20 53,791,428 54,517,691 RGD:8554693
RGD:1624291
G Grik3 glutamate ionotropic receptor kainate type subunit 3 JBrowse link 5 143,500,441 143,715,546 RGD:8554693
G Htr1b 5-hydroxytryptamine receptor 1B JBrowse link 8 89,113,984 89,130,830 RGD:1626454
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link 15 56,666,152 56,732,469 RGD:1624386
G Npy2r neuropeptide Y receptor Y2 JBrowse link 2 181,528,949 181,538,145 RGD:1642508
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6482754
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:10413844
negative regulation of synaptic vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:1624291
RGD:1600115
G Fmr1 fragile X mental retardation 1 JBrowse link X 154,684,924 154,722,369 RGD:11059581
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:1624291
RGD:13792537
G Rap1b RAP1B, member of RAS oncogene family JBrowse link 7 60,850,406 60,878,226 RGD:1624291
RGD:13792537
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:1624291
RGD:1600115
positive regulation of long-term synaptic depression term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy8 adenylate cyclase 8 JBrowse link 7 105,353,883 105,593,372 RGD:1600115
RGD:1624291
G Cbln1 cerebellin 1 precursor JBrowse link 19 20,607,507 20,611,316 RGD:1624291
RGD:1600115
G Grid2 glutamate ionotropic receptor delta type subunit 2 JBrowse link 4 94,068,112 95,476,864 RGD:1600115
RGD:1624291
G Iqsec2 IQ motif and Sec7 domain 2 JBrowse link X 22,212,137 22,293,810 RGD:11049506
G Kcnb1 potassium voltage-gated channel subfamily B member 1 JBrowse link 3 163,850,785 163,935,610 RGD:1600115
RGD:1624291
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:10412705
G Pirb paired Ig-like receptor B JBrowse link 1 64,074,097 64,081,568 RGD:1624291
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A JBrowse link 4 29,976,485 30,247,371 RGD:10002752
G Stau2 staufen double-stranded RNA binding protein 2 JBrowse link 5 2,257,910 2,497,429 RGD:10043164
regulation of long-term synaptic depression term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arc activity-regulated cytoskeleton-associated protein JBrowse link 7 115,907,097 115,911,059 RGD:1600115
RGD:1624291
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:12793033
G Dgki diacylglycerol kinase, iota JBrowse link 4 64,365,115 64,831,473 RGD:1624291
RGD:1600115
G Shank3 SH3 and multiple ankyrin repeat domains 3 JBrowse link 7 130,474,278 130,534,679 RGD:1624291
RGD:7349315
RGD:1600115
G Sorcs3 sortilin-related VPS10 domain containing receptor 3 JBrowse link 1 267,986,305 268,620,331 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17926
    negative regulation of biological process 5362
      negative regulation of signaling 1326
        negative regulation of synaptic transmission 81
          long-term synaptic depression + 35
          negative regulation by symbiont of host synaptic transmission + 0
          negative regulation of excitatory postsynaptic potential + 11
          negative regulation of neuromuscular synaptic transmission 0
          negative regulation of neurotransmitter secretion + 12
          negative regulation of synaptic transmission, GABAergic 8
          negative regulation of synaptic transmission, cholinergic + 1
          negative regulation of synaptic transmission, dopaminergic + 5
          negative regulation of synaptic transmission, glutamatergic + 11
          negative regulation of synaptic transmission, glycinergic + 0
Path 2
Term Annotations click to browse term
  biological_process 17926
    cellular process 16077
      cell communication 7114
        cell-cell signaling 1598
          synaptic signaling 867
            trans-synaptic signaling 859
              anterograde trans-synaptic signaling 850
                chemical synaptic transmission 850
                  modulation of chemical synaptic transmission 642
                    negative regulation of synaptic transmission 81
                      long-term synaptic depression + 35
                      negative regulation by symbiont of host synaptic transmission + 0
                      negative regulation of excitatory postsynaptic potential + 11
                      negative regulation of neuromuscular synaptic transmission 0
                      negative regulation of neurotransmitter secretion + 12
                      negative regulation of synaptic transmission, GABAergic 8
                      negative regulation of synaptic transmission, cholinergic + 1
                      negative regulation of synaptic transmission, dopaminergic + 5
                      negative regulation of synaptic transmission, glutamatergic + 11
                      negative regulation of synaptic transmission, glycinergic + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.