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Term:T cell receptor signaling pathway
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Accession:GO:0050852 term browser browse the term
Definition:A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
Synonyms:exact_synonym: T lymphocyte receptor signaling pathway;   T lymphocyte receptor signalling pathway;   T-cell receptor signalling pathway;   TCR signaling pathway


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T cell receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07049499.1 RGD:13792537
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Bcl10 BCL10, immune signaling adaptor JBrowse link 2 251,805,392 251,814,957 RGD:1624291
RGD:1600115
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:1624291
G Btn1a1 butyrophilin, subfamily 1, member A1 JBrowse link 17 43,899,155 43,909,042 RGD:13792537
G Btn2a2 butyrophilin, subfamily 2, member A2 JBrowse link 17 43,867,243 43,878,734 RGD:13792537
G Btnl10 butyrophilin like 10 JBrowse link 10 45,257,946 45,266,233 RGD:13792537
G Btnl2 butyrophilin-like 2 JBrowse link 20 4,140,184 4,156,365 RGD:13792537
G Btnl3 butyrophilin-like 3 JBrowse link 20 4,156,858 4,171,887 RGD:13792537
G Btnl5 butyrophilin-like 5 JBrowse link 20 2,723,576 2,733,181 RGD:13792537
G Btnl7 butyrophilin-like 7 JBrowse link 20 2,757,008 2,769,215 RGD:13792537
G Btnl8 butyrophilin-like 8 JBrowse link 20 2,845,720 2,863,449 RGD:13792537
G Btnl9 butyrophilin-like 9 JBrowse link 10 34,424,830 34,443,749 RGD:13792537
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 JBrowse link 7 140,311,120 140,324,902 RGD:1624291
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 JBrowse link 3 37,950,846 38,211,478 RGD:1624291
G Carmil2 capping protein regulator and myosin 1 linker 2 JBrowse link 19 37,652,383 37,665,333 RGD:1624291
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:1624291
G Cd247 Cd247 molecule JBrowse link 13 83,996,045 84,071,408 RGD:1624291
RGD:13792537
G Cd276 Cd276 molecule JBrowse link 8 63,312,060 63,350,411 RGD:13792537
G Cd28 Cd28 molecule JBrowse link 9 67,546,408 67,573,858 RGD:1624291
RGD:13792537
RGD:1600115
G Cd3e CD3e molecule JBrowse link 8 49,297,604 49,309,370 RGD:1624291
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:1624291
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:13792537
G Dennd1b DENN domain containing 1B JBrowse link 13 56,015,813 56,242,041 RGD:1624291
RGD:13792537
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha JBrowse link 12 37,444,136 37,452,391 RGD:1600115
RGD:1624291
G Eif2b2 eukaryotic translation initiation factor 2B subunit beta JBrowse link 6 109,044,830 109,051,254 RGD:1600115
RGD:1624291
G Eif2b3 eukaryotic translation initiation factor 2B subunit gamma JBrowse link 5 135,882,946 135,949,276 RGD:1600115
RGD:1624291
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta JBrowse link 6 26,546,917 26,552,474 RGD:1600115
RGD:1624291
G Eif2b5 eukaryotic translation initiation factor 2B subunit epsilon JBrowse link 11 84,080,273 84,090,259 RGD:1600115
RGD:1624291
G Ermap erythroblast membrane associated protein (Scianna blood group) JBrowse link 5 138,227,168 138,240,509 RGD:13792537
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
G Fyb1 FYN binding protein 1 JBrowse link 2 55,834,904 55,983,805 RGD:13792537
G Fyb2 FYN binding protein 2 JBrowse link 5 124,442,386 124,561,766 RGD:1624291
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:1624291
RGD:13792537
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:1624291
RGD:1600115
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:1624291
G Icoslg inducible T-cell co-stimulator ligand JBrowse link 20 11,330,000 11,340,307 RGD:13792537
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
G Itk IL2-inducible T-cell kinase JBrowse link 10 31,431,820 31,493,413 RGD:1624291
RGD:13792537
G Lcp2 lymphocyte cytosolic protein 2 JBrowse link 10 18,996,523 19,043,289 RGD:1624291
G Lime1 Lck interacting transmembrane adaptor 1 JBrowse link 3 176,881,881 176,888,230 RGD:1600115
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:1624291
G LOC100911938 butyrophilin subfamily 3 member A3-like JBrowse link 20 2,813,330 2,825,537 RGD:13792537
G LOC100911983 butyrophilin subfamily 3 member A3-like JBrowse link 20 2,909,473 2,921,680 RGD:13792537
G LOC689599 hypothetical protein LOC689599 JBrowse link 9 114,748,302 114,786,017 RGD:13792537
G Malt1 MALT1 paracaspase JBrowse link 18 61,108,712 61,162,446 RGD:1624291
RGD:13792537
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:1624291
G Mog myelin oligodendrocyte glycoprotein JBrowse link 20 2,003,871 2,014,284 RGD:13792537
G Nfkbid NFKB inhibitor delta JBrowse link 1 88,883,816 88,892,543 RGD:1624291
G Nfkbiz NFKB inhibitor zeta JBrowse link 11 47,243,342 47,271,487 RGD:1624291
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:1624291
G Pde4b phosphodiesterase 4B JBrowse link 5 121,759,236 122,136,814 RGD:1624291
RGD:1600115
G Pde4d phosphodiesterase 4D JBrowse link 2 40,219,999 41,468,551 RGD:1624291
RGD:1600115
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:1624291
RGD:1600115
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:1624291
RGD:1600115
G Pram1 PML-RARA regulated adaptor molecule 1 JBrowse link 7 18,507,878 18,516,321 RGD:13792537
G Prkd2 protein kinase D2 JBrowse link 1 78,767,911 78,796,223 RGD:1624291
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1624291
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:1624291
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:13792537
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
RGD:1358565
RGD:1600115
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 3 147,793,014 147,809,941 RGD:1600115
RGD:1624291
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link 3 21,621,976 21,676,789 RGD:1624291
G Rftn1 raftlin lipid raft linker 1 JBrowse link 9 12,740,885 12,942,358 RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G Rnf31 ring finger protein 31 JBrowse link 15 34,270,037 34,282,385 RGD:1624291
G Shb SH2 domain containing adaptor protein B JBrowse link 5 60,970,650 61,077,881 RGD:1624291
G Skap1 src kinase associated phosphoprotein 1 JBrowse link 10 84,309,379 84,619,051 RGD:1624291
G Skint1 selection and upkeep of intraepithelial T cells 1 JBrowse link 5 131,915,266 131,944,842 RGD:13792537
G Skint10 selection and upkeep of intraepithelial T cells 10 JBrowse link 5 133,048,273 133,067,278 RGD:13792537
G Skint8 selection and upkeep of intraepithelial T cells 8 JBrowse link 5 131,867,780 131,902,258 RGD:13792537
G Spn sialophorin JBrowse link 1 198,572,999 198,585,664 RGD:1358565
G Sppl3 signal peptide peptidase like 3 JBrowse link 12 47,276,485 47,360,552 RGD:1624291
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1624291
RGD:1600115
G Stoml2 stomatin like 2 JBrowse link 5 58,472,561 58,476,158 RGD:1624291
RGD:1600115
G Tec tec protein tyrosine kinase JBrowse link 14 37,918,884 38,027,953 RGD:13792537
G Themis thymocyte selection associated JBrowse link 1 17,152,973 17,378,225 RGD:1624291
RGD:13792537
G Themis2 thymocyte selection associated family member 2 JBrowse link 5 150,971,795 150,986,596 RGD:1624291
RGD:13792537
G Thy1 Thy-1 cell surface antigen JBrowse link 8 48,382,121 48,387,271 RGD:8554466
RGD:13792537
G Tnfrsf21 TNF receptor superfamily member 21 JBrowse link 9 20,546,159 20,621,051 RGD:1624291
RGD:1600115
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
G Txk TXK tyrosine kinase JBrowse link 14 38,029,809 38,085,822 RGD:1624291
RGD:13792537
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 7 36,610,147 36,640,190 RGD:1624291
G Vtcn1 V-set domain containing T cell activation inhibitor 1 JBrowse link 2 203,200,435 203,274,264 RGD:13792537
G Wnk1 WNK lysine deficient protein kinase 1 JBrowse link 4 152,452,211 152,578,469 RGD:1624291
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1624291
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1600115
RGD:1624291
G Zfp683 zinc finger protein 683 JBrowse link 5 152,280,982 152,288,208 RGD:1624291
negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07035561.2 RGD:13792537
G Btn2a2 butyrophilin, subfamily 2, member A2 JBrowse link 17 43,867,243 43,878,734 RGD:1624291
G Btnl2 butyrophilin-like 2 JBrowse link 20 4,140,184 4,156,365 RGD:1624291
RGD:1600115
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:1624291
G Cd160 CD160 molecule JBrowse link 2 198,933,681 198,965,380 RGD:1624291
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Dusp22 dual specificity phosphatase 22 JBrowse link 17 34,986,589 35,037,297 RGD:1624291
G Dusp3 dual specificity phosphatase 3 JBrowse link 10 89,904,578 89,918,296 RGD:1624291
RGD:13792537
G Elf1 E74 like ETS transcription factor 1 JBrowse link 15 61,772,544 61,868,442 RGD:1624291
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:1624291
G Gbp1 guanylate binding protein 1 JBrowse link 2 248,343,334 248,423,402 RGD:1624291
RGD:1600115
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:1624291
G Lilrb4 leukocyte immunoglobulin like receptor B4 JBrowse link 1 73,393,854 73,399,448 RGD:1624291
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:1624291
RGD:1600115
G Phpt1 phosphohistidine phosphatase 1 JBrowse link 3 2,797,037 2,798,436 RGD:1624291
G Prnp prion protein JBrowse link 3 124,515,917 124,531,320 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:1624291
RGD:1600115
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
G Pvrig PVR related immunoglobulin domain containing JBrowse link 12 19,679,671 19,681,861 RGD:1624291
G Thy1 Thy-1 cell surface antigen JBrowse link 8 48,382,121 48,387,271 RGD:1624291
RGD:1600115
G Ubash3a ubiquitin associated and SH3 domain containing, A JBrowse link 20 9,941,102 9,986,012 RGD:1624291
RGD:13792537
positive regulation of T cell receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07032888.1 RGD:13792537
G Ada adenosine deaminase JBrowse link 3 160,115,840 160,139,947 RGD:1624291
G Card11 caspase recruitment domain family, member 11 JBrowse link 12 15,700,600 15,844,512 RGD:1624291
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:1624291
G Cd226 CD226 molecule JBrowse link 18 86,299,392 86,394,772 RGD:1624291
RGD:13792537
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1624291
RGD:1600115
G Kcnn4 potassium calcium-activated channel subfamily N member 4 JBrowse link 1 81,227,855 81,245,986 RGD:1624291
RGD:1600115
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
G Prkd2 protein kinase D2 JBrowse link 1 78,767,911 78,796,223 RGD:1624291
RGD:1600115
G Rab29 RAB29, member RAS oncogene family JBrowse link 13 48,644,575 48,650,229 RGD:1624291
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G Rps3 ribosomal protein S3 JBrowse link 1 164,435,868 164,441,167 RGD:1624291
G Trat1 T cell receptor associated transmembrane adaptor 1 JBrowse link 11 54,619,169 54,661,284 RGD:1624291
regulation of T cell receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl10 BCL10, immune signaling adaptor JBrowse link 2 251,805,392 251,814,957 RGD:1624291
G Cacna1f calcium voltage-gated channel subunit alpha1 F JBrowse link X 15,712,709 15,741,135 RGD:1600115
G Cd300a Cd300a molecule JBrowse link 10 103,437,978 103,451,170 RGD:1624291
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:1624291
G Malt1 MALT1 paracaspase JBrowse link 18 61,108,712 61,162,446 RGD:1624291
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    immune system process 2631
      activation of immune response 389
        immune response-activating signal transduction 292
          immune response-activating cell surface receptor signaling pathway 291
            antigen receptor-mediated signaling pathway 257
              T cell receptor signaling pathway 123
                negative regulation of T cell receptor signaling pathway + 23
                positive regulation of T cell receptor signaling pathway 14
                regulation of T cell receptor signaling pathway + 43
                termination of T cell signal transduction 0
Path 2
Term Annotations click to browse term
  biological_process 19439
    biological regulation 13444
      regulation of biological process 12747
        positive regulation of biological process 6460
          positive regulation of immune system process 1010
            positive regulation of immune response 635
              activation of immune response 389
                immune response-activating signal transduction 292
                  immune response-activating cell surface receptor signaling pathway 291
                    antigen receptor-mediated signaling pathway 257
                      T cell receptor signaling pathway 123
                        negative regulation of T cell receptor signaling pathway + 23
                        positive regulation of T cell receptor signaling pathway 14
                        regulation of T cell receptor signaling pathway + 43
                        termination of T cell signal transduction 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.