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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of T cell receptor signaling pathway
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Accession:GO:0050856 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
Synonyms:exact_synonym: regulation of T lymphocyte receptor signaling pathway;   regulation of T lymphocyte receptor signalling pathway;   regulation of T-cell receptor signalling pathway;   regulation of TCR signaling pathway


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regulation of T cell receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl10 BCL10, immune signaling adaptor ISO MGI:MGI:2158304 (MGI:MGI:3629264|PMID:14614861) RGD PMID:14614861 MGI:MGI:3629264 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:15,712,709...15,741,135
Ensembl chr  X:15,712,713...15,741,103
JBrowse link
G Cd300a Cd300a molecule ISO (PMID:22046970) RGD PMID:22046970 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO (MGI:MGI:3042327|PMID:14752163) RGD PMID:14752163 MGI:MGI:3042327 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Malt1 MALT1 paracaspase ISO MGI:MGI:3639305 (MGI:MGI:3629264|PMID:14614861) RGD PMID:14614861 MGI:MGI:3629264 NCBI chr18:61,108,712...61,162,446
Ensembl chr18:61,109,069...61,162,445
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 ISO (MGI:MGI:3580753|PMID:15917799) RGD PMID:15917799 MGI:MGI:3580753 NCBI chr13:78,723,028...78,794,663
Ensembl chr13:78,722,763...78,789,266
JBrowse link
negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07035561.2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr12:19,680,712...19,681,832 JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 ISO (MGI:MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:MGI:5520006 NCBI chr17:43,867,243...43,878,734
Ensembl chr17:43,868,191...43,879,839
JBrowse link
G Btnl2 butyrophilin-like 2 ISO
IEA
(MGI:MGI:3775536|PMID:16751379)
GO_REF:0000107
RGD
Ensembl
PMID:16751379 GO_REF:0000107, MGI:MGI:3775536 NCBI chr20:4,140,184...4,156,365
Ensembl chr20:4,141,878...4,154,978
JBrowse link
G Cblb Cbl proto-oncogene B ISO MGI:MGI:2180572 (MGI:MGI:3041371|PMID:14738763) RGD PMID:14738763 MGI:MGI:3041371 NCBI chr11:51,037,383...51,202,761
Ensembl chr11:51,037,393...51,202,820
JBrowse link
G Cd160 CD160 molecule ISO (PMID:18193050) RGD PMID:18193050 NCBI chr 2:198,933,681...198,965,380
Ensembl chr 2:198,935,133...198,942,732
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 ISO
ISS
(PMID:18424730)
GO_REF:0000024
RGD
UniProt
PMID:18424730 GO_REF:0000024 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Dgkz diacylglycerol kinase zeta ISS
ISO
GO_REF:0000024
(MGI:MGI:2672999|PMID:12883552)
UniProt
RGD
PMID:12883552 GO_REF:0000024, MGI:MGI:2672999 NCBI chr 3:80,844,002...80,886,487
Ensembl chr 3:80,844,005...80,875,817
JBrowse link
G Dusp22 dual specificity phosphatase 22 ISO (MGI:MGI:5583944|PMID:24714587) RGD PMID:24714587 MGI:MGI:5583944 NCBI chr17:34,986,589...35,037,297
Ensembl chr17:34,986,591...35,037,076
JBrowse link
G Dusp3 dual specificity phosphatase 3 ISO
IBA
(PMID:12447358)
PMID:21873635
RGD PMID:12447358, PMID:21873635 RGD:13792537 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G Elf1 E74 like ETS transcription factor 1 ISO MGI:MGI:1926074 (MGI:MGI:3041371|PMID:14738763) RGD PMID:14738763 MGI:MGI:3041371 NCBI chr15:61,772,544...61,868,442
Ensembl chr15:61,826,711...61,868,343
JBrowse link
G Ezr ezrin ISO (PMID:20551903) RGD PMID:20551903 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Gbp1 guanylate binding protein 1 ISO (PMID:24337748) RGD PMID:24337748 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Laptm5 lysosomal protein transmembrane 5 ISO (MGI:MGI:3803048|PMID:18619870) RGD PMID:18619870 MGI:MGI:3803048 NCBI chr 5:149,015,793...149,069,719
Ensembl chr 5:149,047,681...149,069,719
JBrowse link
G Lgals3 galectin 3 ISO (MGI:MGI:4355752|PMID:19706535) RGD PMID:19706535 MGI:MGI:4355752 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 ISO (PMID:16493035), (PMID:22387553) RGD PMID:16493035, PMID:22387553 NCBI chr 1:73,393,854...73,399,448
Ensembl chr 1:73,393,850...73,399,579
JBrowse link
G Pawr pro-apoptotic WT1 regulator ISO
IEA
MGI:MGI:2678021 (MGI:MGI:2675524|PMID:12970181)
GO_REF:0000107
RGD
Ensembl
PMID:12970181 GO_REF:0000107, MGI:MGI:2675524 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Phpt1 phosphohistidine phosphatase 1 ISO (PMID:18796614) RGD PMID:18796614 NCBI chr 3:2,797,037...2,798,436
Ensembl chr 3:2,796,997...2,798,470
JBrowse link
G Prnp prion protein ISO (MGI:MGI:4943618|PMID:20145049) RGD PMID:20145049 MGI:MGI:4943618 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(MGI:MGI:5320871|PMID:22080863)
GO_REF:0000024
RGD
UniProt
PMID:22080863 GO_REF:0000024, MGI:MGI:5320871 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO (PMID:18056643) RGD PMID:18056643 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO
IEA
MGI:MGI:1856074 (MGI:MGI:82729|PMID:9064344)
GO_REF:0000107
RGD
Ensembl
PMID:9064344 GO_REF:0000107, MGI:MGI:82729 NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J ISO (MGI:MGI:4942249|PMID:12913111)
(PMID:11259588), (PMID:12913111), (PMID:9780142)
RGD PMID:9780142, PMID:11259588, PMID:12913111 MGI:MGI:4942249 NCBI chr 3:79,233,519...79,390,956
Ensembl chr 3:79,233,525...79,390,956
JBrowse link
G Pvrig PVR related immunoglobulin domain containing ISO (PMID:26755705) RGD PMID:26755705 NCBI chr12:19,679,671...19,681,861 JBrowse link
G Sh2d1a SH2 domain containing 1A ISO (PMID:9774102) RGD PMID:9774102 NCBI chr  X:128,897,053...128,925,408
Ensembl chr  X:128,897,181...128,925,407
JBrowse link
G Sla2 Src-like-adaptor 2 ISO (PMID:11891219) RGD PMID:11891219 NCBI chr 3:152,942,838...153,004,047
Ensembl chr 3:152,944,452...153,001,309
JBrowse link
G Thy1 Thy-1 cell surface antigen ISO
ISS
(MGI:MGI:1096761|PMID:9285719)
GO_REF:0000024
RGD
UniProt
PMID:9285719 GO_REF:0000024, MGI:MGI:1096761 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A ISO
IBA
MGI:MGI:107180 (MGI:MGI:3041371|PMID:14738763)
PMID:21873635
RGD PMID:14738763, PMID:21873635 MGI:MGI:3041371, RGD:13792537 NCBI chr20:9,941,102...9,986,012
Ensembl chr20:9,948,908...9,985,133
JBrowse link
positive regulation of T cell receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07032888.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr18:87,415,531...87,415,884 JBrowse link
G Ada adenosine deaminase ISO MGI:MGI:1857117|MGI:MGI:2683027 (MGI:MGI:3640996|PMID:11435465) RGD PMID:11435465 MGI:MGI:3640996 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Card11 caspase recruitment domain family, member 11 ISO (PMID:12154360) RGD PMID:12154360 NCBI chr12:15,700,600...15,844,512
Ensembl chr12:15,700,825...15,844,512
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 ISO (MGI:MGI:3847607|PMID:17785582) RGD PMID:17785582 MGI:MGI:3847607 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cd226 CD226 molecule ISO
IBA
(PMID:26755705)
PMID:21873635
RGD PMID:26755705, PMID:21873635 RGD:13792537 NCBI chr18:86,299,392...86,394,772
Ensembl chr18:86,299,463...86,394,765
JBrowse link
G Cd81 Cd81 molecule ISS
ISO
IEA
GO_REF:0000024
(PMID:23858057)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:23858057 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO
IEA
MGI:MGI:3664438 (MGI:MGI:3656194|PMID:16501569)
GO_REF:0000107
RGD
Ensembl
PMID:16501569 GO_REF:0000107, MGI:MGI:3656194 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ISO
IEA
(PMID:18796614)
GO_REF:0000107
RGD
Ensembl
PMID:18796614 GO_REF:0000107 NCBI chr 1:81,227,855...81,245,986
Ensembl chr 1:81,230,612...81,245,996
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 ISO
IBA
(PMID:26755705)
PMID:21873635
RGD PMID:26755705, PMID:21873635 RGD:13792537 NCBI chr 1:80,631,449...80,666,617
Ensembl chr 1:80,631,450...80,666,585
JBrowse link
G Prkd2 protein kinase D2 ISO
ISS
(MGI:MGI:4849903|PMID:20819079)
GO_REF:0000024
RGD
UniProt
PMID:20819079 GO_REF:0000024, MGI:MGI:4849903 NCBI chr 1:78,767,911...78,796,223
Ensembl chr 1:78,767,911...78,796,231
JBrowse link
G Rab29 RAB29, member RAS oncogene family ISO (PMID:26021297) RGD PMID:26021297 NCBI chr13:48,644,575...48,650,229
Ensembl chr13:48,644,604...48,650,220
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO (PMID:18045535) RGD PMID:18045535 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps3 ribosomal protein S3 ISO (PMID:18045535) RGD PMID:18045535 NCBI chr 1:164,435,868...164,441,167
Ensembl chr 1:164,435,878...164,441,167
JBrowse link
G Trat1 T cell receptor associated transmembrane adaptor 1 ISO (PMID:11390434) RGD PMID:11390434 NCBI chr11:54,619,169...54,661,284
Ensembl chr11:54,619,129...54,662,353
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      regulation of signaling 3492
        regulation of signal transduction 2934
          regulation of antigen receptor-mediated signaling pathway 65
            regulation of T cell receptor signaling pathway 47
              negative regulation of T cell receptor signaling pathway + 27
              positive regulation of T cell receptor signaling pathway 14
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of immune system process 1481
          positive regulation of immune system process 1015
            positive regulation of immune response 655
              activation of immune response 418
                immune response-activating signal transduction 319
                  immune response-activating cell surface receptor signaling pathway 318
                    antigen receptor-mediated signaling pathway 284
                      T cell receptor signaling pathway 129
                        regulation of T cell receptor signaling pathway 47
                          negative regulation of T cell receptor signaling pathway + 27
                          positive regulation of T cell receptor signaling pathway 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.