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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of antigen receptor-mediated signaling pathway
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Accession:GO:0050858 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
Synonyms:exact_synonym: down regulation of antigen receptor-mediated signaling pathway;   downregulation of antigen receptor-mediated signaling pathway;   negative regulation of antigen receptor mediated signalling pathway
 narrow_synonym: inhibition of antigen receptor-mediated signaling pathway


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negative regulation of B cell receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd22 CD22 molecule JBrowse link 1 89,313,475 89,329,902 RGD:1624291
RGD:13792537
G Cd300a Cd300a molecule JBrowse link 10 103,437,978 103,451,170 RGD:1624291
G Fcgr2b Fc fragment of IgG receptor IIb JBrowse link 13 89,329,298 89,343,916 RGD:1624291
G Fcrl5 Fc receptor-like 5 JBrowse link 2 186,776,466 186,797,900 RGD:1624291
G Gps2 G protein pathway suppressor 2 JBrowse link 10 56,524,327 56,527,447 RGD:1624291
G Lpxn leupaxin JBrowse link 1 229,642,437 229,674,129 RGD:1624291
RGD:13792537
G Plcl2 phospholipase C-like 2 JBrowse link 9 1,782,536 1,984,654 RGD:1624291
negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07035561.2 RGD:13792537
G Btn2a2 butyrophilin, subfamily 2, member A2 JBrowse link 17 43,867,243 43,878,734 RGD:1624291
G Btnl2 butyrophilin-like 2 JBrowse link 20 4,140,184 4,156,365 RGD:1624291
RGD:1600115
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:1624291
G Cd160 CD160 molecule JBrowse link 2 198,933,681 198,965,380 RGD:1624291
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Dgkz diacylglycerol kinase zeta JBrowse link 3 80,844,002 80,886,487 RGD:1600115
RGD:1624291
G Dusp22 dual specificity phosphatase 22 JBrowse link 17 34,986,589 35,037,297 RGD:1624291
G Dusp3 dual specificity phosphatase 3 JBrowse link 10 89,904,578 89,918,296 RGD:1624291
RGD:13792537
G Elf1 E74 like ETS transcription factor 1 JBrowse link 15 61,772,544 61,868,442 RGD:1624291
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:1624291
G Gbp1 guanylate binding protein 1 JBrowse link 2 248,343,334 248,423,402 RGD:1624291
RGD:1600115
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:1624291
G Lilrb4 leukocyte immunoglobulin like receptor B4 JBrowse link 1 73,393,854 73,399,448 RGD:1624291
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:1624291
RGD:1600115
G Phpt1 phosphohistidine phosphatase 1 JBrowse link 3 2,797,037 2,798,436 RGD:1624291
G Prnp prion protein JBrowse link 3 124,515,917 124,531,320 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:1624291
RGD:1600115
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
G Pvrig PVR related immunoglobulin domain containing JBrowse link 12 19,679,671 19,681,861 RGD:1624291
G Sh2d1a SH2 domain containing 1A JBrowse link X 128,897,053 128,925,408 RGD:1624291
G Sla2 Src-like-adaptor 2 JBrowse link 3 152,942,838 153,004,047 RGD:1624291
G Thy1 Thy-1 cell surface antigen JBrowse link 8 48,382,121 48,387,271 RGD:1624291
RGD:1600115
G Ubash3a ubiquitin associated and SH3 domain containing, A JBrowse link 20 9,941,102 9,986,012 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    immune system process 2798
      negative regulation of immune system process 474
        negative regulation of antigen receptor-mediated signaling pathway 33
          negative regulation of B cell receptor signaling pathway 7
          negative regulation of T cell receptor signaling pathway + 26
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of immune system process 1502
          positive regulation of immune system process 1060
            positive regulation of immune response 672
              activation of immune response 418
                immune response-activating signal transduction 320
                  immune response-activating cell surface receptor signaling pathway 319
                    antigen receptor-mediated signaling pathway 285
                      regulation of antigen receptor-mediated signaling pathway 64
                        negative regulation of antigen receptor-mediated signaling pathway 33
                          negative regulation of B cell receptor signaling pathway 7
                          negative regulation of T cell receptor signaling pathway + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.