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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of membrane protein ectodomain proteolysis
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Accession:GO:0051043 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).


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negative regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO
ISS
(PMID:18383040)
GO_REF:0000024
RGD
UniProt
PMID:18383040 GO_REF:0000024 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Lrig2 leucine-rich repeats and immunoglobulin-like domains 2 ISO (MGI:MGI:5702499|PMID:26651291) RGD PMID:26651291 MGI:MGI:5702499 NCBI chr 2:206,928,708...206,997,915
Ensembl chr 2:206,931,204...206,997,519
JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 ISO (PMID:12207026) RGD PMID:12207026 NCBI chr 5:74,248,996...74,368,167
Ensembl chr 5:74,248,996...74,368,186
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO
IBA
(PMID:12714508)
PMID:21873635
RGD PMID:12714508, PMID:21873635 RGD:13792537 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO
IBA
IEA
(PMID:18383040)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:18383040, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:147,156,948...147,163,467
Ensembl chr 4:147,156,948...147,163,467
JBrowse link
positive regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 ADAM metallopeptidase domain 8 ISO
IBA
(MGI:MGI:3040545|PMID:14761956)
PMID:21873635
(PMID:15220135), (PMID:17548643)
RGD PMID:14761956, PMID:15220135, PMID:17548643, PMID:21873635 MGI:MGI:3040545, RGD:13792537 NCBI chr 1:212,317,510...212,332,895
Ensembl chr 1:212,317,848...212,330,349
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 ISO (MGI:MGI:1326990|PMID:9857183) RGD PMID:9857183 MGI:MGI:1326990 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Adra2a adrenoceptor alpha 2A ISO (PMID:17655843) RGD PMID:17655843 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Apoe apolipoprotein E IEA
ISO
GO_REF:0000107
UniProtKB:P05067:PRO_0000000092 (PMID:15950758), (PMID:25015123)
Ensembl
RGD
PMID:15950758, PMID:25015123 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein ISO UniProtKB:P02649 (PMID:25015123) RGD PMID:25015123 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5447609|PMID:17720976)
(PMID:17720976)
Ensembl
UniProt
RGD
PMID:17720976 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5447609 NCBI chr17:42,085,027...42,131,344
Ensembl chr17:42,085,028...42,127,678
JBrowse link
G Ifng interferon gamma ISO (PMID:18373975) RGD PMID:18373975 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta ISO
IEA
(PMID:18373975)
GO_REF:0000107
RGD
Ensembl
PMID:18373975 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Nrdc nardilysin convertase ISO
IEA
(PMID:18355445)
GO_REF:0000107
RGD
Ensembl
PMID:18355445 GO_REF:0000107 NCBI chr 5:128,629,949...128,694,209
Ensembl chr 5:128,629,942...128,694,060
JBrowse link
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 ISO (PMID:15280379) RGD PMID:15280379 NCBI chr 3:80,072,425...80,081,058
Ensembl chr 3:80,072,489...80,081,047
JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a ISO (MGI:MGI:5702499|PMID:26651291) RGD PMID:26651291 MGI:MGI:5702499 NCBI chr 1:134,699,053...134,742,512
Ensembl chr 1:134,699,299...134,742,514
JBrowse link
G Sh3d19 SH3 domain containing 19 ISO (PMID:15280379) RGD PMID:15280379 NCBI chr 2:185,268,028...185,431,834
Ensembl chr 2:185,268,259...185,431,354
JBrowse link
G Snx33 sorting nexin 33 ISO (PMID:18353773), (PMID:18419754) RGD PMID:18353773, PMID:18419754 NCBI chr 8:61,584,656...61,596,055
Ensembl chr 8:61,584,656...61,595,032
JBrowse link
G Snx9 sorting nexin 9 ISO (PMID:18353773) RGD PMID:18353773 NCBI chr 1:46,780,142...46,826,250
Ensembl chr 1:46,779,860...46,825,830
JBrowse link
G Tnf tumor necrosis factor ISO (PMID:18373975) RGD PMID:18373975 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO
IBA
(PMID:22480688)
PMID:21873635
RGD PMID:22480688, PMID:21873635 RGD:13792537 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cellular metabolic process 11085
        regulation of cellular metabolic process 6234
          regulation of cellular catabolic process 761
            regulation of membrane protein ectodomain proteolysis 23
              negative regulation of membrane protein ectodomain proteolysis 7
              positive regulation of membrane protein ectodomain proteolysis 16
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      organic substance metabolic process 11651
        macromolecule metabolic process 10086
          protein metabolic process 6228
            proteolysis 1894
              membrane protein proteolysis 58
                membrane protein ectodomain proteolysis 48
                  regulation of membrane protein ectodomain proteolysis 23
                    negative regulation of membrane protein ectodomain proteolysis 7
                    positive regulation of membrane protein ectodomain proteolysis 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.