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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of small GTPase mediated signal transduction
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Accession:GO:0051058 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.
Synonyms:exact_synonym: down regulation of small GTPase mediated signal transduction;   downregulation of small GTPase mediated signal transduction
 narrow_synonym: inhibition of small GTPase mediated signal transduction


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negative regulation of small GTPase mediated signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arhgap12 Rho GTPase activating protein 12 JBrowse link 17 54,280,815 54,394,716 RGD:1624291
G Arhgap25 Rho GTPase activating protein 25 JBrowse link 4 119,249,682 119,327,822 RGD:1624291
RGD:13792537
G Cd2ap CD2-associated protein JBrowse link 9 20,794,680 20,858,438 RGD:1624291
RGD:1600115
G Cgnl1 cingulin-like 1 JBrowse link 8 78,126,670 78,278,490 RGD:1624291
G Cyrib CYFIP related Rac1 interactor B JBrowse link 7 104,514,566 104,641,875 RGD:1624291
G Sh3bp1 SH3-domain binding protein 1 JBrowse link 7 120,125,747 120,138,148 RGD:1600115
RGD:1624291
G Slit2 slit guidance ligand 2 JBrowse link 14 66,831,848 67,171,491 RGD:1600115
RGD:1624291
negative regulation of ARF protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Git1 GIT ArfGAP 1 JBrowse link 10 62,656,000 62,664,467 RGD:11344921
negative regulation of Rac protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 JBrowse link 18 31,112,083 31,138,142 RGD:1624291
G Arhgap24 Rho GTPase activating protein 24 JBrowse link 14 8,383,211 8,600,526 RGD:1624291
RGD:13792537
G Arhgap44 Rho GTPase activating protein 44 JBrowse link 10 51,501,547 51,669,546 RGD:1600115
RGD:13792537
RGD:1624291
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:1624291
RGD:1600115
G Stmn3 stathmin 3 JBrowse link 3 176,808,016 176,816,108 RGD:1624291
RGD:8554560
RGD:1600115
negative regulation of Ras protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:632628
G Dgkz diacylglycerol kinase zeta JBrowse link 3 80,844,002 80,886,487 RGD:1624291
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:1624291
G Fbp1 fructose-bisphosphatase 1 JBrowse link 17 396,175 417,480 RGD:1600115
RGD:1624291
G Lztr1 leucine-zipper-like transcription regulator 1 JBrowse link 11 87,381,638 87,397,849 RGD:1624291
G Mapkap1 MAPK associated protein 1 JBrowse link 3 13,484,952 13,701,772 RGD:1624291
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:1624291
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:1624291
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:1624291
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:729591
G Rabgef1 RAB guanine nucleotide exchange factor 1 JBrowse link 12 29,960,132 30,004,727 RGD:1624291
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:1624291
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:1600115
G Rasa2 RAS p21 protein activator 2 JBrowse link 8 104,417,827 104,542,313 RGD:1600115
G Rasa3 RAS p21 protein activator 3 JBrowse link 16 81,320,090 81,434,239 RGD:1600115
G Rasa4 RAS p21 protein activator 4 JBrowse link 12 23,596,989 23,624,386 RGD:1600115
G Rasal1 RAS protein activator like 1 JBrowse link 12 41,416,218 41,449,445 RGD:1600115
G Rasal3 RAS protein activator like 3 JBrowse link 7 14,403,592 14,419,570 RGD:1624291
G Spry1 sprouty RTK signaling antagonist 1 JBrowse link 2 124,400,689 124,405,331 RGD:1624291
RGD:13792537
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:1624291
RGD:13792537
G Spry3 sprouty RTK signaling antagonist 3 JBrowse link 12 18,930,087 18,940,622 RGD:13792537
G Spry4 sprouty RTK signaling antagonist 4 JBrowse link 18 32,593,370 32,609,890 RGD:13792537
G Stambp Stam binding protein JBrowse link 4 115,249,343 115,277,340 RGD:1624291
G Syngap1 synaptic Ras GTPase activating protein 1 JBrowse link 20 5,535,434 5,564,657 RGD:7241548
RGD:1600115
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
G Timp2 TIMP metallopeptidase inhibitor 2 JBrowse link 10 107,338,465 107,386,072 RGD:1598578
G Tnk1 tyrosine kinase, non-receptor, 1 JBrowse link 10 56,458,650 56,475,183 RGD:1624291
G Trim67 tripartite motif-containing 67 JBrowse link 19 57,554,665 57,593,401 RGD:1624291
negative regulation of Rho protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:1624291
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:8554725
G Adra1b adrenoceptor alpha 1B JBrowse link 10 29,392,762 29,450,644 RGD:8554725
G Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 JBrowse link 18 31,112,083 31,138,142 RGD:1624291
G Arhgap35 Rho GTPase activating protein 35 JBrowse link 1 78,456,409 78,573,374 RGD:1600115
RGD:1624291
G Arhgap42 Rho GTPase activating protein 42 JBrowse link 8 7,210,999 7,446,215 RGD:1624291
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
G Ccdc125 coiled-coil domain containing 125 JBrowse link 2 30,685,845 30,726,617 RGD:1624291
RGD:13792537
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:1600115
RGD:1624291
G Dlc1 DLC1 Rho GTPase activating protein JBrowse link 16 58,776,489 59,247,752 RGD:1600115
RGD:1624291
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1624291
RGD:1600115
G Heg1 heart development protein with EGF-like domains 1 JBrowse link 11 70,234,248 70,322,966 RGD:1624291
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,755 RGD:1624291
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1624291
RGD:1600115
G Kank1 KN motif and ankyrin repeat domains 1 JBrowse link 1 243,201,073 243,398,531 RGD:1624291
G Kctd10 potassium channel tetramerization domain containing 10 JBrowse link 12 47,992,079 48,010,531 RGD:13792537
G Kctd13 potassium channel tetramerization domain containing 13 JBrowse link 1 198,360,627 198,378,935 RGD:1624291
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:1600115
RGD:1624291
G Myoc myocilin JBrowse link 13 80,517,531 80,527,928 RGD:1600115
RGD:1624291
G Rasip1 Ras interacting protein 1 JBrowse link 1 101,609,209 101,621,648 RGD:1624291
G Ripor1 RHO family interacting cell polarization regulator 1 JBrowse link 19 37,555,940 37,584,842 RGD:1624291
G Ripor2 RHO family interacting cell polarization regulator 2 JBrowse link 17 42,324,594 42,549,907 RGD:1624291
RGD:1600115
G Scai suppressor of cancer cell invasion JBrowse link 3 23,357,586 23,474,218 RGD:1624291
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:1624291
G Tnfaip1 TNF alpha induced protein 1 JBrowse link 10 65,791,002 65,805,693 RGD:1624291
RGD:13792537
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    negative regulation of biological process 5617
      negative regulation of signaling 1395
        negative regulation of signal transduction 1232
          negative regulation of intracellular signal transduction 546
            negative regulation of small GTPase mediated signal transduction 64
              negative regulation of Ras protein signal transduction + 57
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13635
      regulation of biological process 12958
        regulation of cellular process 12441
          signal transduction 6967
            intracellular signal transduction 2597
              small GTPase mediated signal transduction 436
                regulation of small GTPase mediated signal transduction 235
                  negative regulation of small GTPase mediated signal transduction 64
                    negative regulation of Ras protein signal transduction + 57
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.