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Term:hepoxilin A3 synthase activity
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Accession:GO:0051120 term browser browse the term
Definition:Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.
Synonyms:xref: reactome:R-HSA-2161794 "Arachidonic acid is converted to HXA3/B3 by ALOX12";   reactome:R-HSA-8942208 "ALOXE3 isomerises 12R-HpETE to HXA3"

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hepoxilin A3 synthase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX15 arachidonate 15-lipoxygenase ISO RGD PMID:15123652 RGD:5509794 NCBI chr 5:31,883,544...31,891,357
Ensembl chr 5:31,882,501...32,038,119
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G ALOXE3 arachidonate lipoxygenase 3 IEA
(PMID:21873635) Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 5:32,917,681...32,941,470
Ensembl chr 5:32,918,065...32,941,752
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  molecular_function 17054
    catalytic activity 5414
      isomerase activity 154
        hepoxilin A3 synthase activity 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.