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ONTOLOGY REPORT - ANNOTATIONS


Term:NK T cell activation
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Accession:GO:0051132 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
Comment:Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repetoire of variable region gene segments.
Synonyms:exact_synonym: NK T lymphocyte activation;   NKT cell activation;   NT cell activation;   natural T cell activation;   natural killer T cell activation


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NK T cell activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4f C-type lectin domain family 4, member F ISO MGI:MGI:5529277 (MGI:MGI:5525181|PMID:23762286) RGD PMID:23762286 MGI:MGI:5525181 NCBI chr 4:115,322,300...115,332,021
Ensembl chr 4:115,322,291...115,332,052
JBrowse link
negative regulation of NK T cell activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule ISO (PMID:10540326) RGD PMID:10540326 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
negative regulation of NK T cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb7b zinc finger and BTB domain containing 7B ISO (MGI:MGI:5449456|PMID:23105140) RGD PMID:23105140 MGI:MGI:5449456 NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704
JBrowse link
NK T cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elf4 E74 like ETS transcription factor 4 ISO (MGI:MGI:2388503|PMID:12387738) RGD PMID:12387738 MGI:MGI:2388503 NCBI chr  X:135,239,626...135,284,330
Ensembl chr  X:135,240,451...135,250,519
JBrowse link
G Il15 interleukin 15 ISO MGI:MGI:2136897 (MGI:MGI:1354083|PMID:10704459) RGD PMID:10704459 MGI:MGI:1354083 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
positive regulation of NK T cell activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule ISO (MGI:MGI:2180705|PMID:10201995), (MGI:MGI:3041278|PMID:11754812), (MGI:MGI:72888|PMID:7538697) RGD PMID:7538697, PMID:10201995, PMID:11754812 MGI:MGI:2180705, MGI:MGI:3041278, MGI:MGI:72888 NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805
JBrowse link
G Il12a interleukin 12A ISO
IEA
(PMID:19088061)
GO_REF:0000107
RGD
Ensembl
PMID:19088061 GO_REF:0000107 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B ISO (PMID:19088061) RGD PMID:19088061 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il23a interleukin 23 subunit alpha ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
positive regulation of NK T cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il12b interleukin 12B ISO (PMID:19088061) RGD PMID:19088061 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il18 interleukin 18 ISO
IEA
(PMID:19088061)
GO_REF:0000107
RGD
Ensembl
PMID:19088061 GO_REF:0000107 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il23a interleukin 23 subunit alpha ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Rasal3 RAS protein activator like 3 ISO (PMID:25652366) RGD PMID:25652366 NCBI chr 7:14,403,592...14,419,570
Ensembl chr 7:14,403,592...14,418,950
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    immune system process 2837
      leukocyte activation 1057
        lymphocyte activation 870
          T cell activation 521
            alpha-beta T cell activation 173
              NK T cell activation 11
                NK T cell activation involved in immune response + 0
                NK T cell proliferation + 7
                negative regulation of NK T cell activation + 2
                positive regulation of NK T cell activation + 6
                regulation of NK T cell activation + 8
Path 2
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      cell activation 1196
        leukocyte activation 1057
          lymphocyte activation 870
            T cell activation 521
              alpha-beta T cell activation 173
                NK T cell activation 11
                  NK T cell activation involved in immune response + 0
                  NK T cell proliferation + 7
                  negative regulation of NK T cell activation + 2
                  positive regulation of NK T cell activation + 6
                  regulation of NK T cell activation + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.