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ONTOLOGY REPORT - ANNOTATIONS


Term:attachment of mitotic spindle microtubules to kinetochore
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Accession:GO:0051315 term browser browse the term
Definition:The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex as part of mitotic metaphase plate congression.
Comment:This class covers transient, lateral attachment to microtubules as well as stable, correctly oriented, end-on attachment (biorientation)
Synonyms:exact_synonym: attachment of spindle microtubules to kinetochore involved in mitosis;   attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation;   attachment of spindle microtubules to mitotic chromosome
 related_synonym: attachment of spindle microtubules to kinetochore during mitosis;   mitotic bipolar attachment
 alt_id: GO:0051314


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attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) RGD PMID:22581055 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Cenpc centromere protein C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:23,611,909...23,670,314
Ensembl chr14:23,611,735...23,670,475
JBrowse link
G Cenpe centromere protein E ISO (PMID:15843429) RGD PMID:15843429 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Champ1 chromosome alignment maintaining phosphoprotein 1 ISO
IBA
(PMID:21063390)
PMID:21873635
RGD PMID:21063390, PMID:21873635 RGD:13792537 NCBI chr16:80,839,373...80,850,340
Ensembl chr16:80,839,374...80,850,340
JBrowse link
G Kif2c kinesin family member 2C IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:23891108)
Ensembl
UniProt
RGD
PMID:23891108 GO_REF:0000024, GO_REF:0000107 NCBI chr 5:136,027,923...136,053,268
Ensembl chr 5:136,027,934...136,053,210
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:16,410,083...16,721,232
Ensembl chr12:16,410,083...16,719,824
JBrowse link
G Mis12 MIS12 kinetochore complex component ISO
IEA
ISS
(PMID:23891108)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:23891108 GO_REF:0000024, GO_REF:0000107 NCBI chr10:57,653,685...57,661,833
Ensembl chr10:57,660,067...57,660,687
JBrowse link
G Ndc80 NDC80 kinetochore complex component ISO
IBA
(PMID:23891108), (PMID:25743205)
PMID:21873635
RGD PMID:23891108, PMID:25743205, PMID:21873635 RGD:13792537 NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382
JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:87,818,456...87,847,223
Ensembl chr13:87,818,391...87,847,263
JBrowse link
G Seh1l SEH1-like nucleoporin ISO (PMID:17363900) RGD PMID:17363900 NCBI chr18:63,545,150...63,568,101 JBrowse link
lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpe centromere protein E ISO (PMID:23891108) RGD PMID:23891108 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
mitotic sister chromatid biorientation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bod1 biorientation of chromosomes in cell division 1 ISO (PMID:17938248), (PMID:24157919) RGD PMID:17938248, PMID:24157919 NCBI chr10:16,259,728...16,266,069
Ensembl chr10:16,259,728...16,266,061
JBrowse link
positive regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 ISO (PMID:23478334) RGD PMID:23478334 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U IEA
IBA
ISO
ISS
GO_REF:0000107
PMID:21873635
(PMID:21242313)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:21242313, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr13:96,222,093...96,238,845
Ensembl chr13:96,225,912...96,238,572
JBrowse link
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B ISO (PMID:28751710) RGD PMID:28751710 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cell cycle process 1210
        attachment of spindle microtubules to kinetochore 34
          attachment of mitotic spindle microtubules to kinetochore 14
            lateral attachment of mitotic spindle microtubules to kinetochore + 2
            mitotic sister chromatid biorientation + 1
            negative regulation of attachment of mitotic spindle microtubules to kinetochore 0
            positive regulation of attachment of mitotic spindle microtubules to kinetochore + 3
            regulation of attachment of mitotic spindle microtubules to kinetochore + 3
Path 2
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          organelle organization 4101
            organelle fission 500
              nuclear division 445
                mitotic nuclear division 283
                  mitotic sister chromatid segregation 158
                    mitotic metaphase plate congression 48
                      attachment of mitotic spindle microtubules to kinetochore 14
                        lateral attachment of mitotic spindle microtubules to kinetochore + 2
                        mitotic sister chromatid biorientation + 1
                        negative regulation of attachment of mitotic spindle microtubules to kinetochore 0
                        positive regulation of attachment of mitotic spindle microtubules to kinetochore + 3
                        regulation of attachment of mitotic spindle microtubules to kinetochore + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.