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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of ligase activity
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Accession:GO:0051340 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
Synonyms:exact_synonym: ligase regulator


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negative regulation of leucine-tRNA ligase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rgn regucalcin JBrowse link X 1,833,484 1,848,904 RGD:9590217
positive regulation of aminoacyl-tRNA ligase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 JBrowse link 12 12,738,784 12,748,345 RGD:1624291
RGD:1600115
positive regulation of DNA ligase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:1624291
RGD:1600115
positive regulation of glutamate-cysteine ligase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:1582663
RGD:13792537
RGD:1624291
positive regulation of isoleucine-tRNA ligase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rpl5 ribosomal protein L5 JBrowse link 14 2,860,963 2,867,397 RGD:11040680
positive regulation of ligase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mid1ip1 MID1 interacting protein 1 JBrowse link X 13,114,557 13,119,274 RGD:1624291
RGD:1600115
G Ripk3 receptor-interacting serine-threonine kinase 3 JBrowse link 15 34,470,796 34,479,741 RGD:1624291
G Xrcc4 X-ray repair cross complementing 4 JBrowse link 2 18,674,496 18,927,463 RGD:1624291
RGD:13792537
positive regulation of methionine-tRNA ligase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rpl5 ribosomal protein L5 JBrowse link 14 2,860,963 2,867,397 RGD:11040680
positive regulation of threonine-tRNA ligase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rpl5 ribosomal protein L5 JBrowse link 14 2,860,963 2,867,397 RGD:1556518

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  biological_process 19312
    biological regulation 13339
      regulation of molecular function 3014
        regulation of catalytic activity 2295
          regulation of ligase activity 8
            negative regulation of ligase activity + 1
            positive regulation of ligase activity + 7
            regulation of DNA ligase activity + 1
            regulation of aminoacyl-tRNA ligase activity + 3
            regulation of argininosuccinate synthase activity + 0
            regulation of glutamate-ammonia ligase activity + 0
            regulation of glutamate-cysteine ligase activity + 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.